Experimental and Clinical Granuloma Inguinale

A Clinical Variant of Chancroid Resembling Granuloma Inguinale

“…5 Generally, there is no inguinal lymphadenop¬ athy unless there is secondary infection,45 but advanced subcutaneous perinodal spread may result in inguinal induration or "pseudobuboes". [5][6][7][8] In contrast, chancroid occurs as one or several shallow saucer-shaped ulcérations or as deeply ero¬ sive, punched-out lesions with a ragged, irregular, and overhanging or undermined border.34511 The floor of the ulcer is usually covered with a necroticappearing or purulent grayish-white exúdate,"1 which discloses a red, granular base similar to that of granuloma inguinale when it is removed.4910 Chancroidal ulcers are usually painful and nonindurated.910 Unlike granuloma inguinale, the lesions of chancroid may progress through a papulopustular phase before ulcerating.34910 Unilateral or bilateral large, discrete inguinal nodes or "buboes" occur in 25% to 60% of cases and often suppurate.34 '11 We observed a relatively large number of patients with nonsyphilitic genital ulcérations having clinical features most suggestive of granuloma inguinale. Because of this unusual frequency of a disease that is rare in this country, we undertook further diagnostic studies in an attempt to confirm our clinical impres¬ sion.…”

Donovanosis

“…Although Anderson has suggested that the classification be changed to Donovania granulomatis in honor of Donovan, the name proposed by the Brazilians continued [4][5][6][7][8].…”

Tropical dermatology: Bacterial tropical diseases

“…In 1939, Greenblatt inoculated the pus from a pseudobubo of a patient with granuloma inguinale into a volunteer, obtaining in the resulting lesion a demonstration of the organism. 35 In 1950, Marmell and Santora proposed the term donovanosis, in homage to Donovan, who first demonstrated the causative agent as bipolar-staining intracellular inclusions in macrophages from lesion exudates. 36 The causative agent is a gram-negative rod with some antigenic properties in common with the Klebsiella group.…”