Tropical dermatology: Bacterial tropical diseases

Lupi, Omar; Madkan, Vandana; Tyring, Stephen K.

doi:10.1016/j.jaad.2005.03.066

Cited by 84 publications

(51 citation statements)

References 90 publications

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“…The tropical ulcer is an extremely painful and debilitating bacterial infection (Lupi et al, 2006). It commonly affects children and adolescents and presents as a rapidly growing ulcer of the lower leg (Adriaans and Drasar, 1987).…”

Section: Introductionmentioning

confidence: 99%

Tropical ulcer plant treatments used by Papua New Guinea's Apsokok nomads

Prescott

Homot

Lundy

et al. 2017

Journal of Ethnopharmacology

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Ethnopharmacological relevanceThe tropical ulcer is a debilitating bacterial infection that is common in Papua New Guinea.Deploying healthcare infrastructure to remote and inaccessible rainforest locations is not practical, therefore local plants may be the best treatment option. Here we present an ethnobotanical survey of the tropical ulcer plant medicines used by the semi-nomadic Apsokok who roam the remote central mountains of Papua New Guinea's West New Britain Province. In vitro biological activity in assays relevant to tropical ulcer wound healing is also presented. Materials and methodsFocus groups and semi-structured interviews were used to acquire information on the uses of plants, vouchers of which were identified by comparison with authentic herbarium specimens. Antibacterial disc diffusion assays with Staphylococcus aureus and Fusobacterium ulcerans, MMP-9 enzyme inhibition and dermal fibroblast stimulation assays were carried out on plant saps and aqueous extracts of plant material. LC-MS was used to identify known plant metabolites. ResultsThe ethnobotanical survey identified sixteen species that were used to treat tropical ulcers, all of which were applied topically. A subset of twelve species were investigated further in vitro. Four species produced zones of inhibition with S. aureus, all 12 species provided low level inhibition of MMP-9 and 8 species stimulated dermal fibroblast proliferation, although cytotoxicity occurred at higher concentrations. The extract of Homalium foetidum Benth. inhibited S. aureus and MMP-9 while at lower sub-cytotoxic concentrations stimulated fibroblast proliferation. Trans-3-O-pcoumaroylquinic acid cis-3-O-p-coumaroylquinic acid were detected in the aqueous extract of H.foetidum. ConclusionsTopical application of plant saps to wounds results in very high localised concentrations of plant metabolites which is likely to result in inhibition of MMP proteases. H. foetidum is a candidate plant for tropical ulcer treatment in remote areas.3

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Section: Introductionmentioning

confidence: 99%

Tropical ulcer plant treatments used by Papua New Guinea's Apsokok nomads

Prescott

Homot

Lundy

et al. 2017

Journal of Ethnopharmacology

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“…Inguinal adenopathy is not present in any of the clinical variants. 3,4 Laboratory diagnosis is performed by direct investigation of Donovan bodies in ulcer smears obtained by punch biopsy or by a biopsy performed on the ulcer (Figure 2). 3 How to cite this article/Como citar este artigo: Bezerra SMFMC, Jardim MML, Silva VB.…”

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confidence: 99%

“…3,4 Laboratory diagnosis is performed by direct investigation of Donovan bodies in ulcer smears obtained by punch biopsy or by a biopsy performed on the ulcer (Figure 2). 3 How to cite this article/Como citar este artigo: Bezerra SMFMC, Jardim MML, Silva VB. Granuloma inguinale (Donovanosis There is abundant granulation tissue at the base of the lesion, which extends beyond the contours of the lesion and bleeds easily.…”

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confidence: 99%

Donovanose

Bezerra

Jardim

Silva

2011

An. Bras. Dermatol.

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Abstract:The authors present images of two of the most common clinical forms of granuloma inguinale (donovanosis) in males and females. Donovanosis is considered a sexually transmitted disease that is endemic in tropical and subtropical regions of the world. Two microscopic images are also shown, one of a direct smear (the presence of Donovan bodies within large mononuclear cells identified using Giemsa stain) and the other of typical histological findings (rod-shaped Donovan bodies within a mononuclear histiocyte). Keywords: Communicable diseases; Genital diseases, female; Genital diseases, male; Sexually transmitted diseases; Sexually transmitted diseases, bacterial Resumo: Os autores apresentam imagens de duas formas clínicas mais frequentes da Donovanose, em ambos sexos. A donovanose é considerada uma doença sexualmente transmissível, endêmica nas regiões tropicais e semitropicais do globo. Apresentam também imagens de duas lâminas: uma da pesquisa direta (corpúsculos de Donovan, dentro de grandes células mononucleadas coradas de vermelho pelo Giemsa) e outra de achados histológicos típicos (formato de alfinete dentro do histiócito). Palavras-chave: Doenças bacterianas sexualmente transmissíveis; Doenças dos genitais femininos; Doenças dos genitais masculinos; Doenças sexualmente transmissíveis; Doenças transmissíveis

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“…It mainly affects the skin and subcutaneous tissue of the genital and perianal areas [1]. Although donovanosis is an intrinsically benign condition effectively treated with numerous antibiotics, the disease is associated with substantial morbidity and mortality.…”

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confidence: 99%

“…Patients often delay seeking treatment for many months, and substantial tissue destruction, including complete erosion of the genitals, may be present [2]. The disease occurs rarely in the United States, although it is endemic in certain tropical and developing areas, including India, Central Australia and southern Africa, Zambia, Morocco and China [1,3]. Recent accurate data for most endemic areas are limited.…”

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confidence: 99%