Air distribution of HVAC systems is the most popular type used in the building sector, having a relevant impact on indoor air quality and occupant wellness. The balance between guaranteeing indoor thermal comfort and reducing energy consumption has become a significant issue in the last years, especially connected to the building construction. In line with this, this research investigates the potentialities of a new air diffuser type, installed in the ceiling of an exhibition room. This system provides a variable mass flow rate thanks to its configuration, allowing to determinate a good thermal comfort. A warm wall is chosen as the heating system. Several tests are carried out, six for cooling and two for heating with different volumetric air rate and supply air temperature of the diffusers. The combination of two methods, the measurements campaigns and the Computational Fluid Dynamics techniques, allows studying the thermal indoor environment. In general, results show a strong capability of this diffuser to provide a uniform temperature and velocity field inside the room. Moreover, experimental and numerical data are significantly comparable giving an average deviation of 1% for the velocity and lower 1% for the temperature. According to this, it is evident that the design of INDULINE allows to obtain optimal temperature and velocity distribution on the vertical and horizontal planes.