Experimental Amyloidosis in the Guinea Pig

The Experimental Production of Arthritis: A Review

“…Their suggestion that the arthritis of rheumatoid arthritis is simply the result of subclinical scurvy modified by streptococcal infection has not been substantiated. Pirani, Bly, and Sutherland (1950) extended the study of scorbutic arthropathy to the guinea-pig. Rawls and Chapman (1935), quoting the work of Cecil, Nicholls, and Stainsby (1931), divided a series of streptococci into those which were agglutinable and those which were inagglutinable and resistant to the bactericidal action of fresh blood.…”

The Relation between Amyloid and Ageing in Comparative Pathology

“…Early experimentors found that caviae were refractory to amyloid induction (cf. the review by Lubarsch, 1897), and only quite recently has the first successful attempt on this species been reported (Pirani et al, 1949). Mice, however, show a very ready tendency to amyloid development, which is apparent also from the wide range of procedures by which amyloidosis may be induced in these animals.…”

The Relationship of Serum Hexosamine, Globulins, and Antibodies to Experimental Amyloidosis1

“…Secondary amyloidosis has been produced in experimental animals by numerous workers (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Whether the amyloid produced in experimental animals is identical in chemical structure and pathogenesis to the primary and secondary amyloid found in human beings has not been established.…”