The Relation between Amyloid and Ageing in Comparative Pathology

Pj, Thung

doi:10.1159/000210701

Cited by 40 publications

(4 citation statements)

References 11 publications

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“…Similar findings in-other organs have been noted in aged dogs, cattle, baboons, and hamsters, and are known to occur spontaneously in certain strains of mice, which are susceptible to experimental induction of amyloid (Thung, 1957). In these mice the experimentally induced amyloidosis is regarded as a precocious variety of the senile form, and Thung suggests that amyloidosis in man may be a comparable condition, and the primary amyloidosis of middle age a pre-senile form of the senile cardiac amyloidosis described in this paper.…”

Section: Discussionsupporting

confidence: 80%

Senile cardiac amyloidosis.

Pomerance¹

1965

Heart

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Although the unexplained occurrence of amyloid deposits in the elderly was first described as long ago as 1876 (Soyka), it is not generally realized that appreciable deposition of amyloid is found in a high proportion of elderly people, and is almost entirely localized to the heart. A preliminary investigation has shown this condition in 10 per cent of patients over 80 dying in this hospital, and an incidence ranging from 2 to 15 per cent has been reported from other countries. If these figures are representative, senile cardiac amyloid would appear to be the commonest existing form of amyloid, and likely to continue increasing with the increasing age of the population.Since clinical signs and symptoms are produced in many cases, and there is an increased likelihood of digitalis sensitivity in patients with cardiac amyloidosis (Cassidy, 1961), this condition should be considered in the differential diagnosis of any elderly patient with congestive heart failure. SUBJECTS AND METHODSThe gross and microscopical pathology and clinical records of 21 patients with senile cardiac amyloidosis were studied. Of these 21, 20 were found in 226 hearts from patients over 75, which formed part of an investigation into various aspects of geriatric heart disease (Pomerance, 1965). The remaining patient was the only previous example in our necropsy records. This was in a man aged 87 in whom a curious greyish black "peppering" of the left atrial endocardium (Fig. 1) had been noted as an incidental finding at necropsy. The nature of this appearance was not clear at the time, but microscopy showed that it was due to nodular deposits of amyloid in the endocardium (Fig. 2 and 4).During the period of the investigation, the hearts of almost all adults dying in this hospital were examined macroscopically in greater detail than usual, while all hearts from patients over the age of 80 were fixed in formalin for subsequent histological examination. A number from younger age-groups have also been fixed and sectioned for comparison, together with all hearts with any lesion, however minor, the nature of which was not immediately apparent from naked eye examination. Altogether 393 hearts were examined after fixation in a 16-months period up to January 1964. The sex and age distribution are shown in Fig. 3.Deposits of amyloid were found in 20: 16 were diagnosed on macroscopic examination by the characteristic appearance of the amyloid nodules in the atrial endocardium, but, in all except the most severely involved hearts, this appearance was not easily visible before formalin fixation and could have been overlooked on inspection of fresh specimens only. For this reason, only hearts which had also been examined after fixation were considered in assessing the proportion of patients in whom predominantly cardiac amyloid deposition was present.In the course of this study it was noted that a high proportion of hearts from patients over 90 showed macroscopically identifiable amyloidosis. The sections of all the patients in this group were therefore re...

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Section: Discussionsupporting

confidence: 80%

Senile cardiac amyloidosis.

Pomerance¹

1965

Heart

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“…The relation between amyloid and aging in the absence of any causative disease has been noted in both humans and laboratory animals (12). The relationship of age and incidence of the amyloid joint in the P series of mice was statistically significant.…”

Section: Discussionmentioning

confidence: 85%

Amyloid Deposition in The Articular Structures of Akr Senescent Mice

Shimizu

Kasai

Yamamuro

et al. 1981

Arthritis & Rheumatism

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Amyloid deposition in the articular structures occurred with high frequency in a strain of mice now being established as an animal model of senescence in this laboratory. The changes were most evident in the knee joint. Peripheral joints were always spared. The lesions appeared after 7 months of age, and the incidence reached 88% (7 of 8) in autopsied mice over 8 months of age. This is the first report of amyloid deposition in the joints of laboratory animals.

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“…Senile amyloidosis is a long-recognized phenomenon in both rodents and humans (76). Its genesis has recently been identified as a posttranslational misfolding of proteins (77).…”

Section: Discussionmentioning

confidence: 99%

The Aging-Disease Dichotomy: True or False?

Blumenthal¹

2003

The Journals of Gerontology Series A: Biological Sciences and M

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The Relation between Amyloid and Ageing in Comparative Pathology

Cited by 40 publications

References 11 publications

Senile cardiac amyloidosis.

Senile cardiac amyloidosis.

Amyloid Deposition in The Articular Structures of Akr Senescent Mice

The Aging-Disease Dichotomy: True or False?

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