Experimental acute sodium fluoride poisoning in sheep: Renal, hepatic, and metabolic effects

Kessabi, M.; Hamliri, A.; Braun, Jean‐Pierre; Rico, A.G.

doi:10.1016/0272-0590(85)90139-3

Cited by 15 publications

(11 citation statements)

References 17 publications

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“…It is shown that there were no clinically adverse, fluoride-induced, extra skeletal physiological, biochemical, or genetic effects of chronic exposure to common levels of fluoride in rats. 38 Above discussed similar experiments with rabbits, 18,20,53 pigs, 13,54 cows, 55,56 sheep, 57 chicken, 58 and squirrel monkeys, the only primate tested 59 showed the same adverse effects on the kidneys due to excess fluoride, further confirming the toxicity of fluoride to the animal kidneys. Further, a recent review article published in 2016 also highlights fluoride-induced nephrotoxicity, including apoptosis, ultrastructural changes, and renal tubular injury in experimental animals.…”

mentioning

confidence: 69%

“…However, his conclusion was “in human cryolite intoxication renal lesion was doubtful, or probably absent.” 13 Contrary to Roholms’ conclusion, in the same year, another study on fluorosis in India reported that “patients show cachexia, loss of appetite and general emaciation and death usually occurring from intercurrent disease.” Further, their kidney functions were impaired in most of the cases. 14 After these early studies, a fair amount of investigations on fluoride toxicity on animals such as rats, mice, rabbits, pigs, cattle, chicken, and squirrel monkeys 13,16 –59 and a limited number on humans 6,16,19,59 …”

Section: Early Studiesmentioning

confidence: 99%

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Exploring the role of excess fluoride in chronic kidney disease: A review

Dharmaratne

2018

Hum Exp Toxicol

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This review covers nearly 100 years of studies on the toxicity of fluoride on human and animal kidneys. These studies reveal that there are direct adverse effects on the kidneys by excess fluoride, leading to kidney damage and dysfunction. With the exception of the pineal gland, the kidney is exposed to higher concentrations of fluoride than all other soft tissues. Therefore, exposure to higher concentrations of fluoride could contribute to kidney damage, ultimately leading to chronic kidney disease (CKD). Among major adverse effects on the kidneys from excessive consumption of fluoride are immediate effects on the tubular area of the kidneys, inhibiting the tubular reabsorption; changes in urinary ion excretion by the kidneys disruption of collagen biosynthesis in the body, causing damages to the kidneys and other organs; and inhibition of kidney enzymes, affecting the functioning of enzyme pathways. This review proposes that there is a direct correlation between CKD and the consumption of excess amounts of fluoride. Studies particularly show immediate adverse effects on the tubular area of human and animal kidneys leading to CKD due to the consumption of excess fluoride. Therefore, it is very important to conduct more investigations on toxicity studies of excess fluoride on the human kidney, including experiments using human kidney enzymes, to study more in depth the impact of excess fluoride on the human kidney. Further, the interference of excess fluoride on collagen synthesis in human body and its effect on human kidney should also be further investigated.

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mentioning

confidence: 69%

Section: Early Studiesmentioning

confidence: 99%

Exploring the role of excess fluoride in chronic kidney disease: A review

Dharmaratne

2018

Hum Exp Toxicol

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“…Fluoride affects the formation of blood forming cells i.e., hematopoietic cells in cavities of bone marrow and inhibits the transport of K + /Cl − ions [17] , [18] . Moreover, it also causes the generation of superoxide radicals (O 2– ), lipid peroxidation in polymorphonuclear leucocytes [19] , [20] and affect the neutrophil along with decreased phagocytic activity [20] .…”

Section: Introductionmentioning

confidence: 99%

Haematological evaluation of sodium fluoride toxicity in oryctolagus cunniculus

et al. 2017

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“…Urine GGT to creatinine ratio has been significantly correlated to the 24h urinary GGT excretion in dogs with gentamicin induced nephrotoxicosis [33]. Increased urine GGT activity has been reported in sheep with induced mercuric chloride nephrotoxicity [34], as well as in sheep after sodium fluoride poisoning associated with kidney degeneration and necrosis predominantly in proximal tubules [35]. Relatedly in experimentally intoxicated sheep after gentamicin administration, urine GGT was proven a suitable early indicator of renal tubular damage [36].…”

Section: Discussionmentioning

confidence: 99%

“…Creatinine is considered as a more specific biomarker of renal dysfunction compared to BUN and phosphate in ruminants. Serum creatinine was significantly higher in ewes with experimentally reduced renal mass compared to intact ones [45], as well as in gentamicin [20] or sodium fluoride intoxicated sheep [35]. However, serum creatinine concentration is not an early biomarker of reduced renal function in sheep as in other species, since creatinine concentration increases after extensive loss of nephron function [19,46].…”

Section: Discussionmentioning

confidence: 99%

Potential Acute Renal Injury in Sheep with Bluetongue Serotype 4

et al. 2021

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Bluetongue is a vector-borne disease with epidemic potential. Recently, outbreaks of Bluetongue were reported across Greece, caused by the Bluetongue virus (BTV) serotype 4. Regarding its pathogenesis, BTV infection involves various target organs with limited data referring to the kidneys. The objective of this study was to identify the possible impact of BTV infection on kidneys using common renal biomarkers. Urine and blood samples collected from 30 sheep with clinical signs of bluetongue (BTV sheep) and 30 clinically healthy sheep (normal sheep) from the same farms were finally selected and included in the study from an initial population of 47 sheep per group, based on the absence of active urine sediment. Complete urinalysis was performed and urine protein to creatinine ratio (UPC) and urine gamma-glutamyl transferase to creatinine (UGGTC) ratio were determined. Blood urea nitrogen (BUN), creatinine, total proteins, albumin (ALB), and inorganic phosphate (P) were determined in serum samples. UPC and UGGTC were significantly higher (p < 0.05) in BTV sheep compared to normal, whereas urine specific gravity (USG) was significantly lower (p < 0.05). Cylindruria was also detected in BTV sheep, and absence of azotemia in BTV and normal sheep. All these findings are indicative of renal tubular injury and/or dysfunction and suggestive of an association between BTV infection and acute damage of renal tissue.

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Experimental acute sodium fluoride poisoning in sheep: Renal, hepatic, and metabolic effects

Cited by 15 publications

References 17 publications

Exploring the role of excess fluoride in chronic kidney disease: A review

Exploring the role of excess fluoride in chronic kidney disease: A review

Haematological evaluation of sodium fluoride toxicity in oryctolagus cunniculus

Potential Acute Renal Injury in Sheep with Bluetongue Serotype 4

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