Haematological evaluation of sodium fluoride toxicity in oryctolagus cunniculus

Abbas, Muhammad; Siddiqi, Muhammad Hassan; Khan, Khushbukhat; Zahra, Kanwal; Naqvi, A. N.

doi:10.1016/j.toxrep.2017.07.002

Cited by 21 publications

(15 citation statements)

References 31 publications

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“…Blood is a very sensitive indicator of the functioning of almost every system of the body. The result of fluoride toxicity recorded during this investigation is similar to the results of fluoride toxicosis study conducted on rabbits by Abbas et al [25]. The lowering the values of RBC, haemoglobin and haematocrit was noted that led to lowering in the values of MCV, MCH, MCHC as well.…”

Section: Resultssupporting

confidence: 89%

“…This suggests the fluoride induced enhancement in Phagocytosis in spleen localized macrophages, which consequently leads to the development of anemia [27,28]. Moreover, fluoride also retards the normal process of erythropoiesis by interacting with the iron of hemoglobin [25]. Measurement of blood erythrocyte antioxidant enzyme activities shows that Fluoride from drinking water increases levels of superoxide dismutase, glutathione peroxidase and catalase [29].…”

Section: Resultsmentioning

confidence: 99%

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Subtle Toxic Manifestation of Fluoride on Haematological Parameters of Freshwater Carp Catla catla (Hemilton)

Mishra¹,

Garima²

2020

AEES

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Fluoride has already been identified as a potential toxic contaminant in the environment causing ailments affecting different systems of body [1]. Toxic manifestation of this element in human beings and other experimental animals is widely documented but very few studies have been conducted on its toxicosis on fish fauna. In this study toxic manifestation of the environmental stress owing to the sub-acute to sub-chronic exposure of fluoride on haematological parameters were evaluated on the chosen fish species Catla catla. The exposure duration was 30, 60, 90 and 120 days. The exposure of excess fluoride concentration in water for long-term duration caused adverse alteration on various parameters of haematopoietic system of the fish. Decrease in haemoglobin, RBC count, MCV, MCH, MCHC and WBC was recorded, and its magnitude was time dependent. These toxic effects are the matter of concern for aquaculture and indicative of the physiological abnormality caused by this environmental contaminant.

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Subtle Toxic Manifestation of Fluoride on Haematological Parameters of Freshwater Carp Catla catla (Hemilton)

Mishra¹,

Garima²

2020

AEES

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“…After 40 days of treatment no significant variation was observed in the bodies' weight, no disturbance of rats' behavior and no death were registered and the rats' organs and bodies weights did not change compared to their respective controls. The increase or reduction in blood parameters (leucocytes, red globules and platelets) are due to infections and other factors like hemorrhages [25,26] . Liver tissue released AST and ALT into circulation in proportion to the degree of damage hepatic cells due to toxic substances, viral infections, or other causes of liver damage [27] .…”

Section: Discussionmentioning

confidence: 99%

Anti-amnesic effects, cerebral protection, and Acute and sub-chronic toxicity studies of Mitragyna inermis (Rubiaceae) leaves decoction

2021

JCBSC

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The aim of our study was to evaluate the anti-amnesic and cerebral protective effects of Mitragyna inermis and to determine its toxic or non-toxic effects. We used rota rod and open field tests for motor coordination or motor memory. We also used biochemical tests or oxidative stress tests such as catalase, superoxide dysmutase and malondialdehyde tests. We finally used toxicity tests such as the evaluation of the number mice and rats died, determination of the alanine amino transferase, aspertate amino transferase and the quantification of blood cells (white and red blood cells, and platelets). We found that M. inermis increased latency of the first fall and decreased the Anti-amnesic… David Bougolla Pahaye et al.

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“…Fifty rats were allocated into 5 groups, each of 10 rats; the first group was the normal control and was given distilled water, the second group was intoxicated with 10 mg/kg SF 24 once daily, the third group was treated with TMQ at a dose of 10 mg/kg/d intraperitoneally, 25 the fourth group was treated with 20 mg/kg/d of NACC, 26 and the fifth group was treated with TMQ and NACC. All treatments were given daily along with SF for 1 month.…”

Section: Methodsmentioning

confidence: 99%

Amelioration of the Protein Expression of Cox2, NFκB, and STAT-3 by Some Antioxidants in the Liver of Sodium Fluoride–Intoxicated Rats

et al. 2018

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The present study aimed to explore the efficiency of N-acetyl cysteine (NACC) or thymoquinone (TMQ) alone or in combination in the downregulation of inflammatory molecule expression and decreasing hepatic injury in response to sodium fluoride (SF). Sodium fluoride upregulated serum alanine and aspartate transferases activities, tumor necrosis factor α and hepatic malondialdehyde and nitric oxide levels, and the expression of cyclooxygenase 2, nuclear factor κB cell, and signal transducer and activator of transcription 3. In contrast, hepatic glutathione level, superoxide dismutase activity, and nuclear factor erythroid 2-related factor 2 expression were decreased. However, the concurrent treatment with antioxidants, alone or in combination, modulated the levels of these parameters. Histopathological examination revealed that SF treatment resulted in focal areas of massive hepatic degeneration and many degenerated hepatocytes, whereas the treatment with TMQ or NACC exhibited moderate improvement in cellular degeneration of the liver with many abnormal cells. Rats receiving a combination of TMQ and NACC showed marked improvement in cellular degeneration of liver with apparently normal hepatic architecture with very few degenerated hepatocytes. The results also revealed that the combination of TMQ and NACC is the most effective regimen in ameliorating SF toxicity, suggesting their efficacy against the toxicity of fluoride compounds. Their activities might be mediated via multiple molecular pathways.

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Haematological evaluation of sodium fluoride toxicity in oryctolagus cunniculus

Abstract: Graphical abstract

Cited by 21 publications

References 31 publications

Subtle Toxic Manifestation of Fluoride on Haematological Parameters of Freshwater Carp Catla catla (Hemilton)

Subtle Toxic Manifestation of Fluoride on Haematological Parameters of Freshwater Carp Catla catla (Hemilton)

Anti-amnesic effects, cerebral protection, and Acute and sub-chronic toxicity studies of Mitragyna inermis (Rubiaceae) leaves decoction

Amelioration of the Protein Expression of Cox2, NFκB, and STAT-3 by Some Antioxidants in the Liver of Sodium Fluoride–Intoxicated Rats

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