Exosomes in lung cancer diagnosis and treatment. From the translating research into future clinical practice

Masaoutis, Christos; Mihailidou, Chrysovalantou; Tsourouflis, Gerasimos; Theocharis, Stamatios

doi:10.1016/j.biochi.2018.05.014

Cited by 72 publications

(46 citation statements)

References 74 publications

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“…Worthy of note, RNA molecules entrapped within exosomes are more resistant than the free form to the activity of RNases [73]. All cell types, including tumor cells, seem to be able to release exosomes into the extracellular space [74]. Once released, exosomes can act as messengers, targeting cells by merging with the plasma membrane or by interacting with protein receptors [75].…”

Section: Exosomesmentioning

confidence: 99%

Liquid Biopsy in Non-Small Cell Lung Cancer: Highlights and Challenges

Rijavec

Coco

Genova

et al. 2019

Cancers

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Non-small cell lung cancer is one leading cause of death worldwide, and patients would greatly benefit from an early diagnosis. Since targeted and immunotherapies have emerged as novel approaches for more tailored treatments, repeated assessments of the tumor biology have become pivotal to drive clinical decisions. Currently, tumor tissue biopsy is the gold standard to investigate potentially actionable biomarkers, but this procedure is invasive and may prove inadequate to represent the whole malignancy. In this regard, liquid biopsy represents a minimally invasive and more comprehensive option for early detection and investigation of this tumor. Today, cell-free DNA is the only approved circulating marker to select patients for a targeted therapy. Conversely, the other tumor-derived markers (i.e., circulating tumor cells, miRNAs, exosomes, and tumor educated platelets) are still at a pre-clinical phase, although they show promising results for their application in screening programs or as prognostic/predictive biomarkers. The main challenges for their clinical translation are the lack of reliable cutoffs and, especially for miRNAs, the great variability among the studies. Moreover, no established tool has been approved for circulating tumor cells and exosome isolation. Finally, large prospective clinical trials are mandatory to provide evidence of their clinical utility.

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Section: Exosomesmentioning

confidence: 99%

Liquid Biopsy in Non-Small Cell Lung Cancer: Highlights and Challenges

Rijavec

Coco

Genova

et al. 2019

Cancers

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“…To date, the literature available on EVs and lung cancer is mainly focused on the exosome population: a significant effort has been employed to define the exosomal miRNA content as diagnostic biomarkers for liquid biopsy, and, in parallel, EV-containing miRNAs have been demonstrated to play pleiotropic functions in regulating tumor malignancy [ 101 ]. A list of the main candidates has been published in a recent review [ 102 ]. However, what is immediately noticeable among these studies is either the variability in the sources of exosomes employed (mainly plasma and also sera or pleural effusions) or the higher variability in the methods to collect exosomes, thus affecting the reproducibility of these data sets.…”

Section: Extracellular Vesicles: Back and Forth Messages To Build mentioning

confidence: 99%

The Crosstalk between Cancer Stem Cells and Microenvironment Is Critical for Solid Tumor Progression: The Significant Contribution of Extracellular Vesicles

Leone

Budillon

2018

Stem Cells International

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Several evidences nowadays demonstrated the critical role of the microenvironment in regulating cancer stem cells and their involvement in tumor progression. Extracellular vesicles (EVs) are considered as one of the most effective vehicles of information among cells. Accordingly, a number of studies led to the recognition of stem cell-associated EVs as new complexes able to contribute to cell fate determination of either normal or tumor cells. In this review, we aim to highlight an existing bidirectional role of EV-mediated communication—from cancer stem cells to microenvironment and also from microenvironment to cancer stem cells—in the most widespread solid cancers as prostate, breast, lung, and colon tumors.

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“…PLC is often accompanied by lung metastasis, abdominal metastasis, mediastinal lymph node metastasis, and even brain metastasis [11][12][13]. The eye is a rare site for liver cancer metastasis owing to the limited number of blood vessels [14] and lymphatic vessels [15] in this organ. Currently, clinical screening methods for early liver cancer mainly include the detection of serum α fetoprotein (AFP) and ultrasound examination of the liver.…”

Section: Introductionmentioning

confidence: 99%

Carbohydrate antigen-125, calcium, and hemoglobin as predictive clinical indicator for ocular metastasis in male liver cancer patients

Zhu

et al. 2020

Bioscience Reports

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Background Primary liver cancer (PLC) is a common type of cancer among men worldwide. Little is known regarding the relationship of liver cancer with ocular metastasis (OM). Drinking has been also reported to be related not only to the occurrence of liver cancer but also to the causes of some ocular lesions. Purpose A diagnostic standard for the levels of serum biomarkers associated with OM derived from liver cancer in men is urgently needed. Material and methods We examined the association between OM in liver cancer and its serum biomarkers. A total of 1254 male patients with liver cancer were recruited in this retrospective study between July 2002 and December 2012. We assessed the relationship between drinking preference and OM in male patients with liver cancer, and aimed to identify an independent prognostic factor or establish a quantitative indicator for OM. Results By assessing the potential indicators, carbohydrate antigen-125 (CA-125), calcium, and hemoglobin (Hb) were found to be most valuable in the diagnosis of OM in male patients with liver cancer. Conclusion CA-125, calcium, and Hb are independent risk factors of OM in patients with liver cancer who consume alcohol.

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Exosomes in lung cancer diagnosis and treatment. From the translating research into future clinical practice

Cited by 72 publications

References 74 publications

Liquid Biopsy in Non-Small Cell Lung Cancer: Highlights and Challenges

Liquid Biopsy in Non-Small Cell Lung Cancer: Highlights and Challenges

The Crosstalk between Cancer Stem Cells and Microenvironment Is Critical for Solid Tumor Progression: The Significant Contribution of Extracellular Vesicles

Carbohydrate antigen-125, calcium, and hemoglobin as predictive clinical indicator for ocular metastasis in male liver cancer patients

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