Carbohydrate antigen-125, calcium, and hemoglobin as predictive clinical indicator for ocular metastasis in male liver cancer patients

Xu, Qianhui; Zhu, Pei‐Wen; Li, Biao; Shi, Wen‐Qing; Qi, Lin; Min, You‐Lan; Ge, Qian‐Min; Yuan, Qing; Shao, Yi

doi:10.1042/bsr20194405

Cited by 7 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…β-globin is selectively increased in cancer cells, mediating a cytoprotective effect during blood-borne metastasis [40]. The normal adult hemoglobin is a predictive clinical indicator for liver cancer combining with combined with CA-125 [35]. In this study, we observed that the expression of hemoglobin, especially HbF, dramatically alters during tumorigenesis of HCC.…”

Section: Discussionmentioning

confidence: 66%

“…As a non-invasive screening of tumors, blood testing, has been paid more and more attention. In addition to circulating tumor cells in peripheral blood, some factors released by tumor cells were found in plasma, and a large number of tumor biomarkers were characterized including CA125 and AFP, of which CA125 is also a sensitive factor in liver cirrhosis [34,35]. The transcriptional information carried by platelets in peripheral blood can be utilized to judge the occurrence and type of tumors [13].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Proteome Expression Profile for Red Blood Cells Enables Diagnostics for Hepatocellular Carcinoma

Wang¹,

Wang²,

Lu³

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroudEarly diagnosis of hepatocellular carcinoma (HCC) has not been clinically resolved, which has been causing more death in patients with HCC. HCC is also a systemic disease related to disorders of blood homeostasis, and the association of red blood cells (RBCs) and HCC tumorigenesis is still elusive. This study explored the protein characteristics of RBCs at the progressive pathological stages comparing with healthy individuals, including liver cirrhosis (LC) and established HCC, to fully understand the tumorigenesis of HCC from a different view and identify potentially novel diagnostic biomarkers for HCC in RBCs.MethodsData independent acquisition (DIA) proteomic analyses were performed with 72 clinical RBCs samples from a cohort of subjects including HCC, LC and healthy controls. Bioinformatics analysis was conducted for significantly differentially expressed proteins (DEPs) through the whole process of tumorigenesis to characterize the clinical relevanve of RBCs and tumorigenesis in HCC. The highly potential tumorigenesis-associated molecular biomarkers were evaluated with clinical samples by parallel reaction monitoring (PRM) technology.ResultsWe observed that red blood cells number dynamically changes during the tumorigenesis of HCC, and LC is a developmental stage more closely approaching HCC based on the protein expresson profiles in RBCs. The expression of hemoglobin (HbA, HbF) in erythroid cells also dynamically alters during the whole process of HCC tumorigenesis, suggesting immature erythroid cells exist in peripheral blood of HCC patients and erythropoiesis in the patients starts to be influenced with the occurance of LC. We observed that the autophagy pathway is disturbed in RBCs with the onset of LC and maintained during the tumorigenesis of HCC. Oxytocin pathway and GnRH pathway are disturbed and first identified during the development of LC into HCC. SMIM1, ANXA7, HBA1 and HBE1 that are significantly altered during tumorigenesis were verified as promising biomarkers for HCC early diagnosis.ConclusionsThis study underlied the clinical relevance of the proteins in RBCs and the tumorigenesis of HCC, and provided the potential biomarkers for early diagnosis in HCC from a new perspective. Our results provided a novel strategy with RBCs for HCC early diagnosis, which will improve the translational research and application in diagnosis of HCC.

show abstract

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Proteome Expression Profile for Red Blood Cells Enables Diagnostics for Hepatocellular Carcinoma

Wang¹,

Wang²,

Lu³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Increasing attention has been paid to blood testing as a non-invasive screening for tumors. In addition to circulating tumor cells in peripheral blood, some factors released by tumor cells are found in plasma, and a large number of tumor biomarkers is characterized, including CA125 and AFP, of which CA125 is also a sensitive factor in LC [ 37 , 38 ]. Transcriptional information carried by platelets in peripheral blood can be utilized to estimate the onset and type of tumors [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Proteome expression profiling of red blood cells during the tumorigenesis of hepatocellular carcinoma

Wang

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

The early diagnosis of hepatocellular carcinoma (HCC) has not been clinically elucidated, leading to an increased mortality rate in patients with HCC. HCC is a systemic disease related to disorders of blood homeostasis, and the association between red blood cells (RBCs) and HCC tumorigenesis remains elusive. We performed data-independent acquisition proteomic analyses of 72 clinical RBC samples, including HCC (n = 30), liver cirrhosis (LC, n = 17), and healthy controls (n = 25), and characterized the clinical relevance of RBCs and tumorigenesis in HCC. We observed dynamic changes in RBCs during HCC tumorigenesis, and our findings indicate that, based on the protein expression profiles of RBCs, LC is a developmental stage closely approaching HCC. The expression of hemoglobin (HbA and HbF) in peripheral blood dynamically changed during HCC tumorigenesis, suggesting that immature erythroid cells exist in peripheral blood of HCC patients and that erythropoiesis is influenced by the onset of LC. We also identified the disrupted autophagy pathway in RBCs at the onset of LC, which persisted during HCC tumorigenesis. The oxytocin and GnRH pathways were disrupted and first identified during the development of LC into HCC. Significantly differentially expressed SMIM1, ANXA7, HBA1, and HBE1 during tumorigenesis were verified as promising biomarkers for the early diagnosis of HCC using parallel reaction monitoring technology. This study may enhance the understanding of HCC tumorigenesis from a different point of view and aid the early diagnosis of HCC.

show abstract

“…However, a cut-off of 2.5 mmol/L of calcium could identify bone metastases in bladder cancer patients with a sensitivity of 32% and a specificity of 94%, with high calcium levels providing an increased risk of metastasis (OR = 13.049, CI: 3.836–44.384, p -value < 0.001) [ 182 ]. A cut-off of 2.7 could identify HCC patients at risk of ocular metastasis with a sensitivity of 19% and a specificity of 97%, with high calcium levels providing an OR of 1.062 (CI: 1.028–1.096) for the risk of metastasis [ 183 ].…”

Section: Calciummentioning

confidence: 99%

Minerals and Cancer: Overview of the Possible Diagnostic Value

Venturelli

Leischner

Helling

et al. 2022

Cancers

View full text Add to dashboard Cite

Cancer is the second leading cause of death worldwide and is expected to increase by one-third over the next two decades, in parallel with the growing proportion of the elderly population. Treatment and control of cancer incidence is a global issue. Since there is no clear way to prevent or cure this deadly malignancy, diagnostic, predictive, and prognostic markers for oncological diseases are of great therapeutic value. Minerals and trace elements are important micronutrients for normal physiological function of the body. They are abundant in natural food sources and are regularly included in dietary supplements whereas highly processed industrial food often contains reduced or altered amounts of them. In modern society, the daily intake, storage pools, and homeostasis of these micronutrients are dependent on certain dietary habits and can be thrown out of balance by malignancies. The current work summarizes the data on minerals and trace elements associated with abnormal accumulation or depletion states in tumor patients and discusses their value as potential tumor-associated biomarkers that could be introduced into cancer therapy.

show abstract

Carbohydrate antigen-125, calcium, and hemoglobin as predictive clinical indicator for ocular metastasis in male liver cancer patients

Cited by 7 publications

References 27 publications

Proteome Expression Profile for Red Blood Cells Enables Diagnostics for Hepatocellular Carcinoma

Proteome Expression Profile for Red Blood Cells Enables Diagnostics for Hepatocellular Carcinoma

Proteome expression profiling of red blood cells during the tumorigenesis of hepatocellular carcinoma

Minerals and Cancer: Overview of the Possible Diagnostic Value

Contact Info

Product

Resources

About