Exosomes and Supported Lipid Layers as Advanced Naturally Derived Drug Delivery Systems

Elnaggar, Mahmoud A.; Joung, Yoon Ki

doi:10.1007/978-981-15-6599-1_18

Cited by 1 publication

(1 citation statement)

References 52 publications

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“…Recent approaches are interested in manufacturing synthetic or semisynthetic EVs for targeted drug delivery. The drugs include proteins and nucleic acids (RNA, miRNA, and siRNA) can be loaded into the EVs through different methods such as electroporation, active loading with saponins, sonication, freezing/thawing, or through extrusion [158,159]. Importantly, the trend in using EVs for lung treatment is still in progress, and some preclinical trials showed its promising therapeutic efficiency because of low immunogenicity and lower toxicity when compared with the cellular therapy [160][161][162][163].…”

Section: Extracellular Vesicle Heat-shock Protein and Mirna Cargo: A Therapeutic Target Worth Consideringmentioning

confidence: 99%

Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors

Alharbi

Lee

Abdelazim

et al. 2021

BioMed Research International

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Extracellular vesicles (EVs), like exosomes, are nanosized membrane-enveloped vesicles containing different bioactive cargo, such as proteins, lipids, mRNA, miRNA, and other small regulatory RNAs. Cell-derived EVs, including EVs originating from stem cells, may capture components from damaged cells or cells impacted by therapeutic treatments. Interestingly, EVs derived from stem cells can be preconditioned to produce and secrete EVs with different therapeutic properties, particularly with respect to heat-shock proteins and other molecular cargo contents. This behavior is consistent with stem cells that also respond differently to various microenvironments. Heat-shock proteins play roles in cellular protection and mediate cellular resistance to radiotherapy, chemotherapy, and heat shock. This review highlights the possible roles EVs play in mediating cellular plasticity and survival when exposed to different physical and chemical stressors, with a special focus on the respiratory distress due to the air pollution.

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Section: Extracellular Vesicle Heat-shock Protein and Mirna Cargo: A Therapeutic Target Worth Consideringmentioning

confidence: 99%

Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors

Alharbi

Lee

Abdelazim

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

show abstract

Exosomes and Supported Lipid Layers as Advanced Naturally Derived Drug Delivery Systems

Cited by 1 publication

References 52 publications

Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors

Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors

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