Exocrine Pancreatic Insufficiency

Batt, R. M.

doi:10.1016/s0195-5616(93)50308-x

Cited by 29 publications

(18 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, Sel1L IKO mice exhibit pancreatic atrophy with defects in nutrient digestion and absorption. The phenotypes of the Sel1L IKO pancreas and mice indeed resemble the condition of exocrine pancreatic insufficiency, a disease often seen in mammals, including humans, dogs, and cats (37). Exocrine pancreatic insufficiency is associated with a reduction in pancreatic enzymes and hence nutrient maldigestion and malabsorption.…”

Section: Resultsmentioning

confidence: 90%

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

Sun

Shi

Han

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

163

239

View full text Add to dashboard Cite

Significance This study provides insights into the physiological role of Sel1L, an adaptor protein for the ubiquitin ligase Hrd1 in endoplasmic reticulum-associated degradation (ERAD). Using both animal and cell models, this study provides unequivocal evidence for an indispensable role of Sel1L in Hrd1 stabilization, mammalian ERAD, endoplasmic reticulum homeostasis, protein translation, and cellular and organismal survival. Moreover, generation of inducible knockout mouse and cell models deficient in both Sel1L and Hrd1 provides an unprecedented opportunity to elucidate the functional importance of this key branch of ERAD in vivo and to identify its physiological substrates.

show abstract

Section: Resultsmentioning

confidence: 90%

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

Sun

Shi

Han

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

163

239

View full text Add to dashboard Cite

show abstract

“…1-4 Lack of pancreatic enzymes in the intestinal lumen causes nutrient malassimilation, resulting in weight loss and soft voluminous stools. [1][2][3] The exocrine portion of the pancreas has a large functional reserve, and human patients with chronic pancreatitis do not develop signs of EPI until more than approximately 90% of the exocrine pancreatic tissue has been destroyed. 4 As in humans, but in contrast to dogs, EPI in cats probably is caused most frequently by chronic pancreatitis.…”

mentioning

confidence: 99%

Serum Feline Trypsin‐Like Immunoreactivity in Cats with Exocrine Pancreatic Insufficiency

Steiner

Williams

2000

Veterinary Internal Medicne

View full text Add to dashboard Cite

Exocrine pancreatic insufficiency is thought to occur rarely in cats. This assumption has been made based on the lack of a specific test for this disease in the cat. Clinical data from the 1st 20 cats with serum feline trypsin-like immunoreactivity (fTLI) concentrations Յ8 g/L are presented. In 17 of these 20 cats compelling evidence for a diagnosis of exocrine pancreatic insufficiency (EPI) was present and in the remaining 3 supportive evidence for a diagnosis of EPI was available. The conclusion was made that serum fTLI concentration is a specific test for EPI in the cat.Key words: Chronic pancreatitis; Diarrhea; Fecal proteolytic activity; Weight loss.E xocrine pancreatic insufficiency (EPI) is caused by lack of synthesis and secretion of digestive enzymes by the exocrine pancreas. 1-4 Lack of pancreatic enzymes in the intestinal lumen causes nutrient malassimilation, resulting in weight loss and soft voluminous stools. [1][2][3] The exocrine portion of the pancreas has a large functional reserve, and human patients with chronic pancreatitis do not develop signs of EPI until more than approximately 90% of the exocrine pancreatic tissue has been destroyed. 4 As in humans, but in contrast to dogs, EPI in cats probably is caused most frequently by chronic pancreatitis. 3,5 Clinical signs reported in cats with EPI include weight loss, soft voluminous stools, and greasy soiling of the hair coat. 2,6 Unfortunately, a diagnosis of EPI is difficult to establish conclusively in cats. Although the clinical presentation may be compatible with a diagnosis of EPI, it is not specific for EPI. Routine laboratory tests may identify increased concentrations of hepatic enzymes, but these findings also are nonspecific and may be found in several other chronic gastrointestinal or systemic diseases. 2 Furthermore, findings on imaging studies, such as abdominal radiography or ultrasonography also are nonspecific. Finally, EPI is not a histopathologic diagnosis. Although a pancreatic biopsy may show histopathologic findings of atrophy, fibrosis, or lack of acinar tissue or zymogen granules within the acinar cells, in most cases some acinar tissue remains and the functional reserve of the exocrine pancreas cannot be estimated from the amount of acinar tissue observed histologically.Most tests of exocrine pancreatic function in cats are unreliable or impractical. 3,7,8 Fecal proteolytic activity has been shown to be useful in the diagnosis of EPI in the cat. 9,10 However, in order to acquire reliable results, at least 3 fecal samples from consecutive days must be collected, stored, and shipped frozen, and analyzed by methods that are not widely available. 10 The diagnosis of EPI in the dog has been improved greatly by the introduction of an assay for trypsin-like immunoreactivity (TLI) in serum. 11,12 This assay is sensitive and specific for the diagnosis of EPI in the dog. 12 A radioimmunoassay (RIA) and an enzyme-linked immunosorbent assay for feline TLI have been developed and validated recently. 13,14 Serum fTLI requires only a s...

show abstract

“…At the same time that the owner noticed the production of the dark urine, the dog had also developed diarrhoea and was diagnosed with exocrine pancreatic insufficiency that responded well to enzyme replacement therapy. In dogs, exocrine pancreatic insufficiency can be caused by pancreatic acinar atrophy, chronic pancreatitis and pancreatic hypoplasia (Batt 1993, Watson 2003). In the present case, pancreatic acinar atrophy could have caused the exocrine pancreatic insufficiency, although pancreatic acinar atrophy was unusual for the age and breed of the dog (Batt 1993).…”

Section: Discussionmentioning

confidence: 99%

“…In dogs, exocrine pancreatic insufficiency can be caused by pancreatic acinar atrophy, chronic pancreatitis and pancreatic hypoplasia (Batt 1993, Watson 2003). In the present case, pancreatic acinar atrophy could have caused the exocrine pancreatic insufficiency, although pancreatic acinar atrophy was unusual for the age and breed of the dog (Batt 1993). Drug‐induced pancreatic lesions have been reported in both human beings (McArthur 1996) and dogs (Simpson 1993).…”

Section: Discussionmentioning

confidence: 99%

Suspected drug‐induced destructive cholangitis in a young dog

Gabriel¹,

Ingh²,

Clercx³

et al. 2006

J of Small Animal Practice

View full text Add to dashboard Cite

A nine-month-old miniature doberman was referred for the evaluation of chronic icterus. History and clinical and histopathological findings were supportive of a diagnosis of drug-induced destructive cholangitis. The main histopathological findings were canalicular, centrilobular cholestasis and ductopenia with moderate inflammatory infiltrate. The dog had received three types of treatment for demodicosis before the onset of jaundice. Amoxicillin-clavulanate, amitraz, milbemycin oxime or an interaction between two of the three drugs may have been responsible for the destructive cholangitis.

show abstract

Exocrine Pancreatic Insufficiency

Cited by 29 publications

References 30 publications

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

Serum Feline Trypsin‐Like Immunoreactivity in Cats with Exocrine Pancreatic Insufficiency

Suspected drug‐induced destructive cholangitis in a young dog

Contact Info

Product

Resources

About