Exhaled breath temperature and exercise‐induced bronchoconstriction in asthmatic children

Peroni, Diego; Chinellato, Iolanda; Piazza, Michele; Zardini, F; Bodini, Alessandro; Olivieri, Francesca; Boner, Attilio; Piacentini, Giorgio

doi:10.1002/ppul.21545

Cited by 17 publications

(16 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous study, we found that an increase in EBT correlated with a decrease in forced expiratory volume in 1 s (FEV 1 ) in both asthmatics and controls after an exercise challenge test [11]. A similar correlation has been found in asthmatic children [12]. In addition, we found that there was a prolonged increase in EBT after exercise in asthmatics for whom the FEV 1 fell during the test compared to asthmatic subjects for whom it did not fall.…”

Section: Introductionsupporting

confidence: 51%

Exhaled Breath Temperature in Asthmatics and Controls after Eucapnic Voluntary Hyperventilation and a Methacholine Challenge Test

Svensson¹,

Bjermer²,

Tufvesson³

2013

Respiration

View full text Add to dashboard Cite

Background: It has been suggested that exhaled breath temperature (EBT) is increased in asthmatic subjects. Objectives: Our aim was to investigate EBT in asthmatics compared to healthy controls before and after eucapnic voluntary hyperventilation (EVH) and a methacholine challenge test (MCT). Methods: A total of 26 asthmatics and 29 healthy controls were included. Forced expiratory volume in 1 s (FEV₁), EBT and oral, axillary and auricular temperatures were measured before and after EVH and MCT. Results: FEV₁ % predicted (%p) was significantly lower in asthmatic subjects compared to healthy controls at all time points. EBT was significantly increased in all subjects 15-30 min after EVH and 5-45 min after MCT. Oral temperature displayed a similar pattern of increase, in contrast to axillary and auricular temperature, and correlated with EBT before and after both of the challenge tests. EBT after 5 min correlated with the largest drop in FEV₁%p after EVH in asthmatic subjects. No significant differences or changes in EBT were found when comparing asthmatics to healthy controls before or after any of the tests. Conclusions: EBT is increased after both EVH and MCT, possibly reflecting a vascular response. This is related to both the fall in FEV₁ and to oral temperature, suggesting an effect on the whole respiratory tract including the oral cavity. No differences in EBT are seen between asthmatics and healthy controls, indicating that the increase in EBT is mainly physiological rather than pathophysiological.

show abstract

Section: Introductionsupporting

confidence: 51%

Exhaled Breath Temperature in Asthmatics and Controls after Eucapnic Voluntary Hyperventilation and a Methacholine Challenge Test

Svensson¹,

Bjermer²,

Tufvesson³

2013

Respiration

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown discrepant results regarding this association. Peroni et al [21] found no correlation with EBTp in 50 children with asthma treated with ICS after exercise-induced bronchoconstriction, while in asthmatic children not treated with ICS they found an increase in EBTp and a decrease in FEV 1 after the same exercise. Svensson et al [22] did not find changes in EBTp in asthma patients before or after two bronchoconstriction tests (eucapnic voluntary hyperventilation and methacholine challenge).…”

Section: Discussionmentioning

confidence: 99%

Usefulness of the Exhaled Breath Temperature Plateau in Asthma Patients

Lessmann

Giner

Torrego³

et al. 2015

Respiration

View full text Add to dashboard Cite

Background: Exhaled breath temperature (EBT) has recently been proposed as a noninvasive marker of bronchial inflammation in patients with asthma. However, the usefulness of EBT in everyday clinical practice is not well established. Results to date are contradictory and are mainly derived from small, pediatric populations. A comparison of results is further complicated by the use of different equipment and measurements. Objective: We performed a comprehensive study to determine whether EBT is related to asthma control, disease severity, bronchial obstruction, or bronchial inflammation. Methods: Sixty-nine patients on maintenance treatment for asthma were included in a cross-sectional study. At the same visit, we measured the EBT plateau (EBTp) using an X-halo Breath Thermometer (Delmedica, Singapore), the fraction of exhaled nitric oxide (FeNO), spirometry, and inflammatory cell count in induced sputum, and we administered the Asthma Control Test questionnaire. Results: No significant differences were found between EBTp measurements and the level of asthma control, disease severity, bronchial obstruction, FeNO levels, or inflammatory asthma phenotypes. We found a significant difference between EBTp and gender. The EBTp was 34.07°C (SD 0.74) in women and 34.38°C (0.46) in men (p = 0.038). We also found a significant correlation between EBTp measurements and the induced sputum eosinophil count (R = -0.348, p = 0.003). Conclusions: The results of this study do not support the usefulness of the EBTp in asthma management in routine clinical practice. Further research using standardized methods is needed to determine the potential use of the EBTp measurement in asthma management.

show abstract

“…It is increased in persistent asthmatics and correlate with other markers of local inflammation (FENO and FEV1) [21,22]. However, we found a low to moderate correlation between frequency of asthma symptoms and local inflammation presented with EBT.…”

Section: Discussionmentioning

confidence: 50%

Association of Asthma Symptoms and Exacerbation with Inflammatory Biomarkers

Navratil¹,

Jureković²,

Topalušić³

et al. 2017

Clin Pediatr OA

View full text Add to dashboard Cite

Objective: To investigate a relationship of asthma symptoms and exacerbations with systemic (high-sensitivity Creactive protein (hs-CRP), eosinophilic cationic protein (ECP), leukocytes) and local (exhaled NO (FENO), pH and urates in exhaled breath condensate (EBC) and exhaled breath temperature (EBT)) inflammatory biomarkers (BMs) in asthmatic children. Methods:This cross-sectional study comprised 93 consecutive asthmatic patients (age 6-18 years, 22 girls) with mild intermittent asthma ([IA], N=44) and mild to moderate persistent asthma ([PA], N=49). Medical history (asthma symptoms and exacerbation), pulmonary function, FENO, EBT, samples of exhaled breath and peripheral blood were collected.Results: Local BMs (EBC urates and EBT) showed stronger correlation with asthma symptoms then systemic BMs (hs-CRP, blood count with differencials) (r=0.26-0.68, r=0.06-0.32, p<0.05; respectively). Single measurements of inflammatory BMs are not good predictors for future asthma exacerbation (binary logistic regression; χ²=13.9; df=11; p=0.238). Conclusion:Study of combination of various exhaled breath and exhaled breath condensate BMs should continue, especially in longitudinal studies with repeated measurements of BMs.

show abstract

Exhaled breath temperature and exercise‐induced bronchoconstriction in asthmatic children

Cited by 17 publications

References 39 publications

Exhaled Breath Temperature in Asthmatics and Controls after Eucapnic Voluntary Hyperventilation and a Methacholine Challenge Test

Exhaled Breath Temperature in Asthmatics and Controls after Eucapnic Voluntary Hyperventilation and a Methacholine Challenge Test

Usefulness of the Exhaled Breath Temperature Plateau in Asthma Patients

Association of Asthma Symptoms and Exacerbation with Inflammatory Biomarkers

Contact Info

Product

Resources

About