Exhaled breath markers of alveolar macrophage activity in sarcoidosis

Mohan, Nitin; Akter, Rabeya; Bryant, Katherine; Herbert, Cristan; Chow, S. P.; Thomas, Paul S.

doi:10.1007/s00011-016-0929-y

Cited by 9 publications

(17 citation statements)

References 26 publications

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“…In our study, TNF-α was detectable in the EBC of all subjects, as in previous studies in chronic obstructive pulmonary disease (COPD) (Ko et al, 2009) but unlike in cleaning workers with asthma for which the detection rate was lower (30%) (Viczaya et al, 2013). Values measured in our study were similar to those measured in other healthy population but were lower than those reported in sarcoidosis (3.37 pg.mL -1 ) and in systemic sclerosis patients (13.5 pg.mL -1 ) (Mohan et al, 2016;Edmé et al, 2008). As salivary contamination could occur in EBC sampling, it is worth noting that salivary influence on the cytokine assessment in EBC may be negligible (Ichikawa et al, 2007).…”

Section: Discussionsupporting

confidence: 89%

Effects of occupational exposure to poorly soluble forms of beryllium on biomarkers of pulmonary response in exhaled breath of workers in machining industries

et al. 2016

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Section: Discussionsupporting

confidence: 89%

Effects of occupational exposure to poorly soluble forms of beryllium on biomarkers of pulmonary response in exhaled breath of workers in machining industries

et al. 2016

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“…Conductivity is evaluated using B-771 LAQUAtwin ® Horiba, where it was measured by the 2-AC bipolar method. In patients with sarcoidosis, conductivity in exhaled breath condensate was significantly higher than healthy controls [ 56 ].…”

Section: Methodsmentioning

confidence: 99%

Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial)

Silva

Moreira

Sokhatska

et al. 2018

Contemporary Clinical Trials Communications

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BackgroundThe effect of a pre-exercise meal as countermeasure to exercise induced immunodepression is poorly known. Also, sedentary behavior is associated with increased cardiometabolic risk but studies on immune changes are lacking. Therefore, we aimed to assess: 1) the impact of a pre-exercise Mediterranean meal (MdM) compared with a fast-food type meal (FFM) on exercise-induced immunological changes and 2) the impact of an induced acute period of sedentary behavior on neuro-immune-endocrine status.Methods/Design: This is a two steps clinical trial including: (a) randomized crossover clinical trial, comparing the effect a high-fat/low-nutrient dense meal, FFM, with an isoenergetic similar high-nutrient dense meal, MdM, in the immune response to an exercise challenge (EC) and (b) a pilot trial assessing the neuro-immune-endocrine change induced by acute decreasing by half the usual physical activity level.ResultsA total of 46 participants (26 females), median aged 25 years were included. Of those 39-completed protocol, including overweight, physical active and inactive and participants with asthma. There were no differences in the EC between interventions. Dietary factors and physical activity were closely monitored during interventions and kept similar. During physical inactivity induction, 31% reached the target of 50% reduction in mean step number and 77% reached a 30% reduction.ConclusionThe use of a pre-exercise meal to modulate immune response and the understanding of the immunological impact of physical inactivity might help to establish future recommendations on how to practice exercise in a safer way and to recognize the potential impact of inactivity.

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“…A subanalysis of these proteins and inflammatory markers is required to specifically identify the important cytokines and signaling proteins involved in sarcoidosis and are differentially expressed. [100][101][102][103] Original work from our laboratory has demonstrated that EBC TGF-β1, an inflammatory mediator involved in sarcoidosis, and neopterin are elevated in patients with sarcoidosis compared with healthy individuals. 102 Another advantage of evaluating EBC biomarkers is that the technique is totally non-invasive.…”

Section: Exhaled Breath Condensatementioning

confidence: 99%

“…60 100 104-107 In order to further develop the EBC technique in clinical care, much work has been focused on standardisation of EBC collection for use in clinical practice. 100 A summary of key studies which demonstrate the BALF biomarkers that are differentially expressed in patients with sarcoidosis compared with healthy controls is demonstrated in table 2 but more work is required to better characterize EBC findings in sarcoidosis and establish those that are most reliable.…”

Section: Exhaled Breath Condensatementioning

confidence: 99%

“…The concentration of total protein and some inflammatory modulators are significantly elevated in EBC from sarcoidosis compared with healthy subjects and this elevation is in agreement with studies of BALF. A subanalysis of these proteins and inflammatory markers is required to specifically identify the important cytokines and signaling proteins involved in sarcoidosis and are differentially expressed 100–103. Original work from our laboratory has demonstrated that EBC TGF-β1, an inflammatory mediator involved in sarcoidosis, and neopterin are elevated in patients with sarcoidosis compared with healthy individuals 102…”

Section: Biomarkers For Clinical Evaluationmentioning

confidence: 99%

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Potential Use of Biomarkers for the Clinical Evaluation of Sarcoidosis

Mousapasandi

Herbert

Thomas

2021

Journal of Investigative Medicine

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Sarcoidosis is a systemic granulomatous disease of unknown etiology and pathogenesis with a heterogeneous clinical presentation. In the appropriate clinical and radiological context and with the exclusion of other diagnoses, the disease is characterized by the pathological presence of non-caseating epithelioid cell granulomas. Sarcoidosis is postulated to be a multifactorial disease caused by chronic antigenic stimulation. The immunopathogenesis of sarcoidosis encompasses a complex interaction between the host, genetic factors and postulated environmental and infectious triggers, which result in granuloma development.The exact pathogenesis of the disease has yet to be elucidated, but some of the inflammatory pathways that play a key role in disease progression and outcomes are becoming apparent, and these may form the logical basis for selecting potential biomarkers.Biomarkers are biological molecules that are altered pathologically. To date, there exists no single reliable biomarker for the evaluation of sarcoidosis, either diagnostically or prognostically but new candidates are emerging. A diagnosis of sarcoidosis ideally requires a biopsy confirming non-caseating granulomas, but the likelihood of progression that requires intervention remains unpredictable. These challenging aspects could be potentially resolved by incorporating biomarkers into clinical practice for both diagnosis and monitoring disease activity.This review outlines the current knowledge on sarcoidosis with an emphasis on pulmonary sarcoidosis, and delineates the understanding surrounding the implication of biomarkers for the clinical evaluation of sarcoidosis.

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Exhaled breath markers of alveolar macrophage activity in sarcoidosis

Abstract: Total protein and TNF-α concentrations were elevated in EBC from patients with sarcoidosis and could indicate disease activity. The reduction in EBC Ca(2+) concentrations could represent granulomatous activity in the lung.

Cited by 9 publications

References 26 publications

Effects of occupational exposure to poorly soluble forms of beryllium on biomarkers of pulmonary response in exhaled breath of workers in machining industries

Effects of occupational exposure to poorly soluble forms of beryllium on biomarkers of pulmonary response in exhaled breath of workers in machining industries

Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial)

Potential Use of Biomarkers for the Clinical Evaluation of Sarcoidosis

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