Effects of occupational exposure to poorly soluble forms of beryllium on biomarkers of pulmonary response in exhaled breath of workers in machining industries

Abstract

Our results suggest that machining-related exposure to Be is related to pulmonary inflammation involving TNF-α. These findings must be confirmed by larger studies.

Exhaled breath NOx levels in a middle-aged adults population-based study: reference values and association with the smoking status

“…The analysis of pulmonary biomarkers in EBC provides a useful approach to the pathophysiology of pulmonary disease [4]. Biomarkers in EBC also have potential as sensitive indicators of early biochemical changes in the airways of subjects exposed to pneumotoxic substances, in either environmental or occupational exposure scenarios [5,6], and particularly for susceptible subjects with pulmonary diseases [7].…”

Role of Heavy Metals in the Incidence of Human Cancers

“…Much of the focus has been to address issues correlated with lung exposure. One carcinogenic mechanism studied was the link between the elevated levels of tumor necrosis factor alpha (TNF-α), which is a cytokine secreted from a specific type of T-cell (CD4 + ) that are present in the lung [30,34]. This factor plays an important role in the development and induction of inflammation [30,34].…”

“…Role of Heavy Metals in the Incidence of Human Cancers DOI: http://dx.doi.org /10.5772/intechopen.98259 The association between TNF-α and beryllium implicates a direct link to the action of chronic inflammation exposure [30,34].…”

Heavy Metals and Cancer

“…For instance, one potentially carcinogenic mechanism identified was its role in inducing a higher level of tumor necrosis factor alpha (TNF-α) cytokine secretion from CD4+ T-cells in the lungs [30,34]. Both of these proteins have a role in the inflammation process, and their elevated presence was suspected to have action in chronic inflammation [30,34]. Beryllium also has the potential to induce inappropriate genetic changes.…”