Exfoliative cytology and the early diagnosis of oral cancer

Ingram, Robert C.; Krantz, Simon; Mendeloff, Joseph; H, Leslie

doi:10.1002/1097-0142(196302)16:2<160::aid-cncr2820160203>3.0.co;2-3

Cancer

1963

DOI: 10.1002/1097-0142(196302)16:2<160::aid-cncr2820160203>3.0.co;2-3

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Exfoliative cytology and the early diagnosis of oral cancer

Robert C. Ingram

Simon Krantz

Joseph Mendeloff

et al.

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1963

2006

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Cited by 19 publications

(1 citation statement)

References 6 publications

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“…3,4 The problems of this type of study have been discussed. 5,6 False positive results in cytologic evaluation present no significant problem, since immediate follow-up and biopsy is mandatory in order to confirm the diagnosis of carcinoma. False negative results in cytologic evaluation present a real hazard in cancer management, since biopsy will often not be done until such time as the clinical features of a proliferating and spreading malignancy render the biopsy necessary.…”

mentioning

confidence: 99%

Reliability of Cytologic Smear in Diagnosis of Oral Cancer: A Controlled Study

Shklar¹,

Cataldo²,

Meyer³

1970

Archives of Otolaryngology - Head and Neck Surgery

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mentioning

confidence: 99%

Reliability of Cytologic Smear in Diagnosis of Oral Cancer: A Controlled Study

Shklar¹,

Cataldo²,

Meyer³

1970

Archives of Otolaryngology - Head and Neck Surgery

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Exfoliative cytology in laryngology: Comparison of cytologic and histologic diagnoses in 350 microlaryngoscopic examinations–A prospective study

Lundgren

Olofsson

Hellquist

et al. 1981

Cancer

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In a prospective study comprising 350 microlaryngoscopic examinations, the reliability of exfoliative cytologic diagnosis was evaluated in comparison with the histologic findings. In 157 of 190 lesions with histologically moderate and severe dysplasia, carcinoma in situ, and invasive carcinoma, the cytologic smears were positive. The sensitivity of the exfoliative cytologic method in the detection of "malignant" lesions was thus 83%. False-negative smears were more common after radiotherapy and in the group with moderate dysplasia. In 134 of 160 histologically benign lesions, the cytologic evaluation was negative. The specificity of the smear test was thus 84%. In at least one case the cytologic examination disclosed true malignancy that had been overlooked at biopsy.

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Scanning electron microscopy in oral cytology

Chomette

Auriol

Vaillant

1986

Diagnostic Cytopathology

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Sixty-three cell smears from oral mucosa were studied by scanning electron microscopy. Among them, smears from ten healthy controls showed three kinds of cells: flat (superficial) cells with linear anastomosing microridges and microvilli; polygonal (intermediate) cells with well-defined crests between their faces and numerous microvilli; and round (parabasal) cells entirely covered by microvilli. Twenty-five smears from patients with untreated squamous-cell carcinoma showed enlarged polymorphous cells (round, globular, and elongated); microvilli, variable in their dimensions, were irregularly distributed on their surfaces. Eighteen smears from patients with severe epithelial dysplasia showed polymorphous cells with discontinuous but obvious edges separating their faces and with irregular microvilli and ridges. Nine smears were also performed in patients with various other mucosal lesions (lichen planus, leukoplakia, white sponge naevus, pemphigus vulgaris, and herpes). All of these smears were studied comparatively between examination of smears and biopsies by light microscopy. The smears were truly reliable, particularly for distinguishing between dysplastic and tumoral cells.

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Exfoliative cytology and the early diagnosis of oral cancer

Cited by 19 publications

References 6 publications

Reliability of Cytologic Smear in Diagnosis of Oral Cancer: A Controlled Study

Reliability of Cytologic Smear in Diagnosis of Oral Cancer: A Controlled Study

Exfoliative cytology in laryngology: Comparison of cytologic and histologic diagnoses in 350 microlaryngoscopic examinations–A prospective study

Scanning electron microscopy in oral cytology

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