Scanning electron microscopy in oral cytology

Chomette, G; Auriol, M; Vaillant, Jean

doi:10.1002/dc.2840020204

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…analysis of healthy oral mucosa showed, as for non-smoker patients, polygonal cells arranged to form a mosaic pattern (6,8,II) and the presence of numerous longitudinal and parallel microcrests on cell surfaces, amply anastomosed to each other (14)(15)(24)(25)(26)(27)(28). Furthermore, on the crests of the surface cells, microvilli were often visibile (8). On the contrary, the samples from smoker patients, presented large areas of desquaming, because of a major keratinisation induced by smoke, with crests reduced in number and height compared to the healthy mucosa of non-smokers with no presence of microvilli on the crests.…”

Section: Fig 3 A-b-c-d-e: Oral Mucosa Affected By Lichen Planus Aftmentioning

confidence: 99%

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SEM Analysis of Oral Lichen Planus before and after Treatment with 13 Cis-Retinoic Acid

Mastrangelo

Dolci

Stuppia

et al. 2007

Int J Immunopathol Pharmacol

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patients suffering from lichen planus and 20 control patients with healthy oral mucous were selected, From the case histories, of the patients suffering from lichen a good ability to modulate the inflammation and the locoregional immune response. In the case of severe symptoms, the association of systemic steroids may be indicated in the initial phase of the treatment (18).The association of antimicrobes improves the clinical results as it eliminates the proliferation C. Albicansand prevents eventual infection consequent to the use of corticosteroids (17). Because ofthe antikeratinizing and immunomodulating properties, topical preparations based on vitamin A (retinoid) seem to have a key role in the treatment of the reticular and plaque forms, reducing the consequences of the use of corticosteroids. Some authors show how the use of Isotretinoina (or 13 cis-retinoic acid) at 0.1% in gel form induced the clinical resolution of reticular and plaque lesions of oral lichen planus (19)(20)(21)(22)(23).Various studies are reported in the literature on scanning electron microscope (SEM) analysis of the characteristics of healthy and diseased oral mucous cell surfaces (4-5, 11-15), but none have used this method for evaluating the effects of treatment of the precancerous lesions. The aim of this study is to analyse and compare the morphology of surfaces of oral mucous affected by lichen planus, before and after treatment, with those of healthy oral mucous. Cancer of the oral cavity is a frequent worldwide neoplasia, averaging 4% in men and 2% in women. Cancer of the oral cavity is often preceded by particular epithelial lesions, called "precancerous lesions". The aim of this study is to evaluate, by SEM microscope analysis, before and after treatment with 0.1 % 13-cis-retinoic, the morphostructural variation of the surface of the oral mucous affected by lichen planus in respect to healthy oral mucous. Following topical therapy with 0.1% 13-cis-retinoic acid for 8 weeks, a restoration of the physiological morphostructure was observed by SEM, demonstrating the efficaciousness of the treatment and the SEM analysis for identifying the lesions of oral epithelium. SEM ANALYSIS OF ORAL LICHEN PLANUS BEFORE AND AFTER TREATMENT WITH 13 cis-RETINOIC ACID

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Section: Fig 3 A-b-c-d-e: Oral Mucosa Affected By Lichen Planus Aftmentioning

confidence: 99%

“…For a precocious diagnosis of the precancerous lesions with degenerative potential, the characterization of surface models by S.E.M. analysis has been used, an instrument that has been used in the past by various researchers to analyse the morphologic aspect of different tissues (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16).…”

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confidence: 99%