Exercise training reduces pulmonary ischaemia-reperfusion-induced inflammatory responses

Mussi, Ricardo Kalaf; Camargo, Enilton A.; Ferreira, T; Moraes, Camila de; Delbin, Maria Andréia; Toro, Ivan Felizardo Contrera; Brancher, S; Landucci, E C T; Zanesco, Angelina; Antunes, Edson

doi:10.1183/09031936.00015607

Cited by 32 publications

(44 citation statements)

References 32 publications

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“…However, endurance exercise caused a decrease in serum TNF-α level (30). In the present study, a signifi cant reduction in the serum TNF-α level was observed after 4 weeks of exercise training in rats (p < 0.05).…”

Section: Table 3 the Effects Of Exercise On Intestinal Tissue Injurysupporting

confidence: 50%

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Effects of exercise preconditioning on intestinal ischemia- -reperfusion injury

Gökbel¹,

M²,

Okudan³

et al. 2014

BLL

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Abstract:Background: To investigate the effects of exercise preconditioning on oxidative injury in the intestinal tissue of rats. Methods: Sixty male Wistar rats were randomly divided into six groups as sham (n = 10), ischemia-reperfusion (n = 10), exercise (n = 10), exercise plus ischemia-reperfusion (n = 10), ischemic preconditioning (n = 10), and ischemic preconditioning plus ischemia-reperfusion groups (n = 10). Tissue levels of malondialdehyde and activities of myeloperoxidase and superoxide dismutase, and serum levels of tumor necrosis factor-alpha and interleukin-6 were measured. Intestinal tissue histopathology was also evaluated by light microscopy. Results: Tumor necrosis factor-alpha concentrations signifi cantly decreased in the exercise group compared to the sham group (p < 0.05). Myeloperoxidase activity signifi cantly increased and superoxide dismutase activity signifi cantly decreased in ischemia-reperfusion group compared to the sham group (p < 0.05). Superoxide dismutase activity in the ischemic preconditioning and ischemic preconditioning plus ischemia-reperfusion groups were signifi cantly higher compared to the ischemia-reperfusion and exercise groups (p < 0.05). Histopathologically, intestinal injury signifi cantly attenuated in the exercise plus ischemia-reperfusion group compared to the ischemia-reperfusion group. Conclusions:The results of the present study indicate that exercise training seems to have a protective role against intestinal ischemia-reperfusion injury (Tab. 3, Fig. 1, Ref. 35). Text in PDF www.elis.sk.

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Section: Table 3 the Effects Of Exercise On Intestinal Tissue Injurysupporting

confidence: 50%

“…SOD activity in IPC+I/R group was signifi cantly higher than in I/R group. The protective effect of exercise against I/R injury has been investigated in several studies (23,24,30). The mechanisms of action of exercise on I/R injury are not clearly understood.…”

Section: Table 3 the Effects Of Exercise On Intestinal Tissue Injurymentioning

confidence: 99%

Effects of exercise preconditioning on intestinal ischemia- -reperfusion injury

Gökbel¹,

M²,

Okudan³

et al. 2014

BLL

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“…TNF-a, IL-1b E IL-6, followed very little by anti-inflammatory cytokines, such as IL-10 and IL-1 11 . TNF-a and IL-1b stimulate the production of IL-6, which induces the acute phase of the inflammatory response [11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

“…TNF-a and IL-1b stimulate the production of IL-6, which induces the acute phase of the inflammatory response [11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

Analysis of the physical activity effects and measurement of pro-inflammatory cytokines in irradiated lungs in rats

Bianchi¹,

Ropelle

Katashima³

et al. 2012

Acta Cir. Bras.

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Brazil. Tutor, responsible for conception, design, intellectual and scientific content of the study, critical analysis, final approval of manuscript. VI Full Professor, Department of Surgery, UNICAMP, Campinas-SP, Brazil. Critical revision and analysis of data. ABSTRACT PURPOSE:To study if the pre-radiotherapy physical activity has radio-protective elements, by measuring the radio-induced activation of pro-inflammatory cytokines as interleukin-6 (il-6), transforming growth factor -b (tgf -b), tumor necrosis factor -a (tnf-a) and protein beta kinase b (ikkb), through western blotting analysis. METHODS:A randomized study with 28 Wistar hannover rats, males, with a mean age of 90 days and weighing about 200 grams. The animals were divided into three groups: (GI, GII and GIII). GIII group were submitted to swimming for eight weeks (zero load, three times a week, about 30 minutes). Then, the groups (except the control group) were submitted to irradiation by cobalt therapy, single dose of 3.5 gray in the whole body. All animals were sacrificed by overdose of pentobarbital, according to the time for analysis of cytokines, and then a fragment of the lower lobe of the right lung went to western blotting analysis. RESULTS:The cytokines IKK b, TNF-a and IL-6 induced by radiation in the lung were lower in the exercised animals. However, exercise did not alter the radiation-induced increase in tgf-b. CONCLUSION:The results show a lower response in relation to inflammatory cytokines in the group that practiced the exercise preradiotherapy, showing that exercise can protect tissues from tissue damage due to irradiation.Key words: Radiotherapy. Radiation Pneumonitis. Pulmonary Fibrosis. Physical Therapy Modalities. Rats. RESUMO OBJETIVO:Verificar se a radioterapia pré-atividade física tem elementos de rádio-proteção, medindo-se a ativação de citocinas pró-inflamatórias como a interleucina-6 (IL-6), fator transformador de crescimento -b (TGF -b), fator de necrose tumoral -a (TNF-a) e quinase de proteína beta b (IKK b), por meio da análise blotting ocidental. MÉTODOS:Um estudo randomizado empregando 28 ratos Wistar Hannover, machos, com idade média de 90 dias e pesando cerca de 200 gramas. Os animais foram divididos em três grupos: (GI, GII e GIII). Os animais do grupo GIII foram submetidos à natação durante oito semanas (carga zero, três vezes por semana, cerca de 30 minutos). Então, os grupos (exceto o grupo controle) foram submetidos à irradiação por cobalto terapia, dose única de 3,5 cinza em todo o corpo. Todos os animais foram sacrificados por overdose de pentobarbital, de acordo com o tempo de análise de citocinas, em seguida, um fragmento do lobo inferior do pulmão direito foi a Bianchi RCG et al. -Acta Cirúrgica Brasileira -Vol. 27 (3) 2012análise de mata-borrão ocidental. RESULTADOS:As citocinas IKK b, TNF-a e IL-6 induzidas por radiação no pulmão foram menores nos animais que se exercitaram.No entanto, o exercício não alterou o aumento induzido pela radiação na TGF-b. CONCLUSÃO:Os resultados mostraram uma menor respost...

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“…Despite the role of exercise as prevention against inflammatory diseases, and more specifically, against pulmonary diseases related to the process of IR, it still requires more studies. Recent researches in our laboratories using experimental models of pulmonary IR showed that moderate physical preconditioning, promotes significant beneficial effects [1][2][3]. Therefore, physical preconditioning can be of great relevance either to reduce comorbidities or to prevent postsurgical complications associated to the process of pulmonary IR.…”

Section: Introductionmentioning

confidence: 99%

Papel do exercício físico na isquemia/reperfusão pulmonar e resposta inflamatória

Delbin

Antunes

Zanesco

2009

Rev Bras Cir Cardiovasc

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Advances in new technologies associated with improvement of knowledge in medicine have promoted important development in therapeutic and preventive approaches in an attempt to diminish complications following cardiothoracic process involving ischemia/ reperfusion (IR). Nevertheless, postoperative pulmonary injuries remain high and are considered one of the most frequent complications after cardiothoracic surgery. Thus, new strategies with prophylactic actions are crucial in the cardiovascular area in an attempt to reduce complications and to improve patients life. It is well documented that moderate exercise training is a non-pharmacological tool to prevent and/or treat the cardiovascular and endocrinemetabolic diseases. The aim of this review was to provide an update of several studies on pulmonary IR process and its local and systemic complications and the role of inflammatory response. Furthermore, this review focused on the effects of exercise training on the pulmonary IR as an important strategy to diminish its complications. This review shows that few studies exist regarding the healthpromoting physical exercise in cardiothoracic surgery and how important and necessary it is to increase studies in this area. Recently, studies from our laboratory showed beneficial effects of exercise training in experimental model of pulmonary IR. Collectively, data show that physical preconditioning for patients is a very important approach to reduce postsurgical complications as well as diminish the time of hospitalization which includes a specialized personal trainer in the health team. Moreover, this preventive strategy might improve patient recovery and would lead to consuming less resources of the health care system. This review included experimental studies in English and Portuguese found in SciELO and MEDLINE (from 1987 to 2008) and also classical texts related to the topic. Rev Bras Cir Cardiovasc 2009; 24(4): 552-561 Descriptors

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Exercise training reduces pulmonary ischaemia-reperfusion-induced inflammatory responses

Cited by 32 publications

References 32 publications

Effects of exercise preconditioning on intestinal ischemia- -reperfusion injury

Effects of exercise preconditioning on intestinal ischemia- -reperfusion injury

Analysis of the physical activity effects and measurement of pro-inflammatory cytokines in irradiated lungs in rats

Papel do exercício físico na isquemia/reperfusão pulmonar e resposta inflamatória

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