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Brazil. Tutor, responsible for conception, design, intellectual and scientific content of the study, critical analysis, final approval of manuscript. VI Full Professor, Department of Surgery, UNICAMP, Campinas-SP, Brazil. Critical revision and analysis of data. ABSTRACT PURPOSE:To study if the pre-radiotherapy physical activity has radio-protective elements, by measuring the radio-induced activation of pro-inflammatory cytokines as interleukin-6 (il-6), transforming growth factor -b (tgf -b), tumor necrosis factor -a (tnf-a) and protein beta kinase b (ikkb), through western blotting analysis. METHODS:A randomized study with 28 Wistar hannover rats, males, with a mean age of 90 days and weighing about 200 grams. The animals were divided into three groups: (GI, GII and GIII). GIII group were submitted to swimming for eight weeks (zero load, three times a week, about 30 minutes). Then, the groups (except the control group) were submitted to irradiation by cobalt therapy, single dose of 3.5 gray in the whole body. All animals were sacrificed by overdose of pentobarbital, according to the time for analysis of cytokines, and then a fragment of the lower lobe of the right lung went to western blotting analysis. RESULTS:The cytokines IKK b, TNF-a and IL-6 induced by radiation in the lung were lower in the exercised animals. However, exercise did not alter the radiation-induced increase in tgf-b. CONCLUSION:The results show a lower response in relation to inflammatory cytokines in the group that practiced the exercise preradiotherapy, showing that exercise can protect tissues from tissue damage due to irradiation.Key words: Radiotherapy. Radiation Pneumonitis. Pulmonary Fibrosis. Physical Therapy Modalities. Rats. RESUMO OBJETIVO:Verificar se a radioterapia pré-atividade física tem elementos de rádio-proteção, medindo-se a ativação de citocinas pró-inflamatórias como a interleucina-6 (IL-6), fator transformador de crescimento -b (TGF -b), fator de necrose tumoral -a (TNF-a) e quinase de proteína beta b (IKK b), por meio da análise blotting ocidental. MÉTODOS:Um estudo randomizado empregando 28 ratos Wistar Hannover, machos, com idade média de 90 dias e pesando cerca de 200 gramas. Os animais foram divididos em três grupos: (GI, GII e GIII). Os animais do grupo GIII foram submetidos à natação durante oito semanas (carga zero, três vezes por semana, cerca de 30 minutos). Então, os grupos (exceto o grupo controle) foram submetidos à irradiação por cobalto terapia, dose única de 3,5 cinza em todo o corpo. Todos os animais foram sacrificados por overdose de pentobarbital, de acordo com o tempo de análise de citocinas, em seguida, um fragmento do lobo inferior do pulmão direito foi a Bianchi RCG et al. -Acta Cirúrgica Brasileira -Vol. 27 (3) 2012análise de mata-borrão ocidental. RESULTADOS:As citocinas IKK b, TNF-a e IL-6 induzidas por radiação no pulmão foram menores nos animais que se exercitaram.No entanto, o exercício não alterou o aumento induzido pela radiação na TGF-b. CONCLUSÃO:Os resultados mostraram uma menor respost...

Introduction: Cardiac hypertrophy is an established cardiovascular risk factor and left ventricular hypertrophy (LVH) is an independent predictor of cardiovascular disease in hypertension. The underlying mechanisms for the unfavourable prognosis in patients with LVH are, however, not fully understood.The vascular endothelium plays a key role in the regulation of vascular tone. Several studies indicate endothelial dysfunction in hypertension associated with cardiovascular complications. In the contest of endothelial dysfunction, considerable interest focuses on cell adhesion molecules (CAMs) like E-selectin, Intercellular Adhesion Molecule-1 (ICAM-1), and Vascular Cell Adhesion Molecule-1 (VCAM-1).These molecules are important in inflammation and they have been hypothesised to play a major role in early atherogenesis. Cell adhesion molecules are released from endothelial cells, and elevated levels of CAMs are generally considered to reflect endothelial cell activation in vivo. Furthermore, previous studies have suggested that hypertensive patients have elevated circulating cell adhesion molecule levels. Objective: The present study thus examines possible relationship between serum levels of CAMs and left ventricular mass in patients with essential hypertension. Methods: Therefore in the present study we examined 100 never treated mild-moderate essential hypertensive(n=50 with LVH and n=50 without LVH) and 40 healthy normotensive patients.In all subjects LVMI (echocardiography) and serum soluble cell adhesion molecules (ICAM-1, VCAM-1, E-selectin) levels were determined (ELISA, R&D System). Results: VCAM-1, ICAM-1, and E-selectin levels were higher in hypertensives with LVH than in hypertensives without LVH and normotensives.These data show that levels of CAMs are higher in hypertensives with LVH and that VCAM-1 is significantly correlated with LVMI. Conclusions: In conclusion, increased levels of soluble CAMs seems to be prognostic factors concerning the development of hypertensive LVH.

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