Exercise training improves acetylcholine-induced endothelium-dependent hyperpolarization in type 2 diabetic rats, Otsuka Long-Evans Tokushima fatty rats

Minami, Asako; Ishimura, Noriko; Harada, Nagakatsu; Sakamoto, Sadaichi; Niwa, Yasuharu; Nakaya, Yutaka

doi:10.1016/s0021-9150(01)00685-2

Cited by 57 publications

(51 citation statements)

References 21 publications

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“…Moreover, exercise decreased oxidized LDL-potentiated platelet activation, most likely by enhancing platelet-derived NO release and bioactivity. Exercise also prevented impairment of vascular dysfunction in type 2 diabetic rats, presumably due to improvement of hyperglycemia and insulin resistance and increased production of NO (64). Thus, progressive adaptation to graduated exercise may represent an economical therapy to preserve health and diminish the rate of decline of the physiological processes associated with aging.…”

Section: Discussionmentioning

confidence: 97%

Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice

Napoli

Williams-Ignarro

Nigris

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

105

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CorrectionsPHARMACOLOGY. For the article ''Beneficial effects of antioxidants and L-arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress,'' by Filomena de Nigris, Lilach O. Lerman, Sharon Williams Ignarro, Giacomo Sica, Amir Lerman, Wulf Palinski, Louis J. Ignarro, and Claudio Napoli, which appeared in issue 3, February 4, 2003, of Proc. Natl. Acad. Sci. USA (100, 1420-1425 first published January 13, 2003; 10.1073͞pnas.0237367100), the authors should have noted that Louis J. Ignarro developed and markets Niteworks, a dietary supplement of L-arginine, L-citrulline, vitamin E, and vitamin C. Dr. Ignarro is also a member of the Scientific Advisory Board of Herbalife, the distributor of Niteworks. The pathogenic mechanisms by which physical exercise influences atherosclerotic lesion formation remain poorly understood. Because vigorous physical training increases oxidative stress, this study tested the hypothesis that graduated and moderate physical exercise together with metabolic intervention (L-arginine and antioxidants) may contribute to increased vascular protection. Exercise training in mice was induced by graduated swimming. In hypercholesterolemic male mice on an atherogenic high-cholesterol diet, graduated and moderate exercise lowered plasma cholesterol and decreased atherosclerotic lesions compared with sedentary control mice. Antioxidants (1.0% vitamin E added to the chow and 0.05% vitamin C added to the drinking water) and L-arginine (6% in drinking water) supplementation to exercising hypercholesterolemic mice further and synergistically reduced atherosclerosis compared with untreated exercised mice. Arterial oxidation-specific epitopes and systemic oxidative stress were reduced by metabolic intervention. Graduated chronic exercise elicited an increase in production of nitric oxide through increased endothelial nitric oxide synthase expression and ameliorated scavenger activities. Thus, metabolic intervention with L-arginine and antioxidants together with graduated and moderate exercise training reduce atherosclerotic lesion formation.catalase ͉ nitric oxide synthase ͉ vitamin E ͉ oxidative stress ͉ low-density lipoprotein P hysical exercise is a deterrent of cardiovascular disease and atherogenesis in animal models (1-5). Exercise can also positively influence classical risk factors that are associated with coronary heart disease such as diabetes, hypertension, obesity, dyslipidemias, and endothelial dysfunction (6-8). The higher respiration rate during severe physical exercise leads to the generation of more free radicals than the endogenous antioxidant systems can scavenge (9), whereas moderate intensity aerobic exercise enhances endothelium dependent vasodilation in humans (10), and attenuates exercise-induced peroxidation (11) and cardiovascular mortality (12) in the elderly. Moreover, there is an inverse association between intensity of physical activity and the risk of coronary heart disease events (13). A metaanalysis of 51 con...

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Section: Discussionmentioning

confidence: 97%

Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice

Napoli

Williams-Ignarro

Nigris

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

105

View full text Add to dashboard Cite

show abstract

“…It has been shown that prostanoids contribute to endothelium-mediated vasodilation in response to acute exercise (Duffy et al, 1999). Studies performed in animals have shown an increase in EDHF-mediated vasodilation induced by training (Minami et al, 2002). The same mechanisms are speculated to also play a role in humans.…”

Section: Exercise Augments the Endothelium Dependent Vasodilation In mentioning

confidence: 99%

Assessment of Human Skin Microcirculation and Its Endothelial Function Using Laser Doppler Flowmetry

Lenasi¹

2011

Medical Imaging

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“…Furthermore, other studies (Chen et al, 1994;Delp and Laughlin, 1997;Clarkson et al, 1999;Minami et al, 2002;Kobayashi et al, 2003;Meyer et al, 2006;) have revealed that aerobic exercise training is very efficient for prevention and for non-pharmacological treatment of these cardiovascular diseases, improving endothelial function and attenuating adrenergic vasoconstrictor response in both healthy individuals and individuals who have this vasomotor response altered. This effect of exercise training observed on arterial vasomotion is very consistent in the scientific community.…”

Section: Introductionmentioning

confidence: 99%

A single bout of moderate-intensity exercise increases vascular NO bioavailability and attenuates adrenergic receptor-dependent and -independent vasoconstrictor response in rat aorta

Bechara

Tanaka

Santos

et al. 2008

J. Smooth Muscle Res.

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The present study investigated the effect of one bout of moderate-intensity exercise on the adrenergic receptor-dependent and -independent vasoconstrictor response in rat aortas, and the role of nitric oxide (NO) bioavailability on these vasomotor responses. One group of rats was submitted to a 60 min of exercise at approximately 60% of maximal exercise capacity on a treadmill (exercise group) and the other one was placed in the treadmill without running (control group). Immediately after this period, both groups were euthanized and the thoracic aorta was removed to evaluate the vasoconstrictor response to norepinephrine and potassium chloride, and to evaluate the vascular nitrite and nitrate concentration. One bout of exercise attenuated the maximal contractile response to both norepinephrine and potassium chloride compared to control group. These differences on vascular reactivity were not observed in endothelium-denuded aortic rings and aortic rings pre-incubated with a nitric oxide synthesis inhibitor. Additionally, exercise group increased NO bioavailability (nitrite and nitrate concentration) as compared to control group. These results demonstrate that one bout of moderate-intensity exercise is able to attenuate adrenergic receptor-dependent and -independent vasoconstrictor response in rat aorta, mainly by increasing vascular NO bioavailability.

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Exercise training improves acetylcholine-induced endothelium-dependent hyperpolarization in type 2 diabetic rats, Otsuka Long-Evans Tokushima fatty rats

Cited by 57 publications

References 21 publications

Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice

Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice

Assessment of Human Skin Microcirculation and Its Endothelial Function Using Laser Doppler Flowmetry

A single bout of moderate-intensity exercise increases vascular NO bioavailability and attenuates adrenergic receptor-dependent and -independent vasoconstrictor response in rat aorta

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