Exercise Therapy and Other Types of Physical Therapy for Patients With Neuromuscular Diseases: A Systematic Review

Cup, Edith; Pieterse, Allan J.; Broek-Pastoor, Jessica M. ten; Munneke, Marten; Engelen, Baziel G. van; Hendricks, Henk T.; Wilt, Gert Jan van der; Oostendorp, Rob A.B.

doi:10.1016/j.apmr.2007.07.024

Cited by 166 publications

(113 citation statements)

References 87 publications

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“…Crucially, these can occur before significant fat infiltration or atrophy is present, and alterations in water load may offer markers indicating successful application of a therapy to its target. Indeed, for novel therapies that may involve exercise itself,18 quantifying such muscle changes under these circumstances is essential. Therefore methods to detect water changes sensitively at an early stage by quantifying T 2 , in early disease and then progressively as fat begins to encroach simultaneously with evolving water changes, have been receiving increased attention.…”

Section: Discussionmentioning

confidence: 99%

Stability and sensitivity of water T₂ obtained with IDEAL‐CPMG in healthy and fat‐infiltrated skeletal muscle

et al. 2016

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Quantifying muscle water T 2 (T 2‐water) independently of intramuscular fat content is essential in establishing T 2‐water as an outcome measure for imminent new therapy trials in neuromuscular diseases. IDEAL‐CPMG combines chemical shift fat–water separation with T 2 relaxometry to obtain such a measure. Here we evaluate the reproducibility and B 1 sensitivity of IDEAL‐CPMG T 2‐water and fat fraction (f.f.) values in healthy subjects, and demonstrate the potential of the method to quantify T 2‐water variation in diseased muscle displaying varying degrees of fatty infiltration.The calf muscles of 11 healthy individuals (40.5 ± 10.2 years) were scanned twice at 3 T with an inter‐scan interval of 4 weeks using IDEAL‐CPMG, and 12 patients with hypokalemic periodic paralysis (HypoPP) (42.3 ± 11.5 years) were also imaged. An exponential was fitted to the signal decay of the separated water and fat components to determine T 2‐water and the fat signal amplitude muscle regions manually segmented.Overall mean calf‐level muscle T 2‐water in healthy subjects was 31.2 ± 2.0 ms, without significant inter‐muscle differences (p = 0.37). Inter‐subject and inter‐scan coefficients of variation were 5.7% and 3.2% respectively for T 2‐water and 41.1% and 15.4% for f.f. Bland–Altman mean bias and ±95% coefficients of repeatability were for T 2‐water (0.15, −2.65, 2.95) ms and f.f. (−0.02, −1.99, 2.03)%. There was no relationship between T 2‐water (ρ = 0.16, p = 0.07) or f.f. (ρ = 0.03, p = 0.7761) and B 1 error or any correlation between T 2‐water and f.f. in the healthy subjects (ρ = 0.07, p = 0.40). In HypoPP there was a measurable relationship between T 2‐water and f.f. (ρ = 0.59, p < 0.001).IDEAL‐CPMG provides a feasible way to quantify T 2‐water in muscle that is reproducible and sensitive to meaningful physiological changes without post hoc modeling of the fat contribution. In patients, IDEAL‐CPMG measured elevations in T 2‐water and f.f. while showing a weak relationship between these parameters, thus showing promise as a practical means of quantifying muscle water in patient populations.

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Section: Discussionmentioning

confidence: 99%

Stability and sensitivity of water T₂ obtained with IDEAL‐CPMG in healthy and fat‐infiltrated skeletal muscle

et al. 2016

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“…In most of the studies included in the review, the cycling or treadmill exercises done at least three times a week and the use of approximately 70% of the heart rate reserve or the use of an estimated maximum heart rate are recommended. It is stated that the whole program lasting at least 10 weeks for both muscle strengthening and aerobic exercises and regular physical therapist supervision increases the effectiveness and improves the safety and suitability of the exercise [181]. However, in only 30% of all studies involving muscle strengthening and aerobic exercises, training lasted for less than 10 weeks, with an average of 5 weeks.…”

Section: Aerobic Endurance Trainingmentioning

confidence: 99%

Neuromuscular Diseases and Rehabilitation

Demir¹

2017

Neurological Physical Therapy

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Neuromuscular diseases (NMDs) are a heterogeneous group of diseases that are inherited or acquired, resulting from an abnormality in the anterior horn motor cells, peripheral nerves, neuromuscular junctions, or muscles.In NMDs, evaluation is performed to monitor the progression of the disease, to determine the appropriate treatment methods, to investigate the efficacy of treatment methods, and to predict and prevent possible complications. Evaluation methods should include evaluation of respiratory functions, muscle testing, normal joint movement, evaluation of flexibility, evaluation of motor functions and functional capacities, functional posture, and gait analysis.The aim of physiotherapy approaches is to improve the quality of life of patients and their families. The rehabilitation program should include the protection of the functional level of the patient and the physical and psychological functions, increasing the physical and mental capacity of the patient, and slowing the progress of the disease symptoms. The rehabilitation program should include the preservation of muscle strength, an exercise program for the prevention of contractures, increasing respiratory function and aerobic capacity, gait and balance training, fall prevention, walking aid training, psychosocial approach, vocational counseling, ergotherapy processes and nutrition expert support.

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“…Assistance in clinical decisions, treatment, prevention of any complications (like respiratory failure or retractions), indication of the type and intensity of exercise are important aspects to be considered (57,58).…”

Section: Wwwintechopencommentioning

confidence: 99%

Motor Function Measure Scale (MFM): New Instrument for Follow-Up Brazilian Patients with Neuromuscular Disease

Iwabe¹,

Nucci²,

Pfeilsticker³

et al. 2012

Muscular Dystrophy

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Exercise Therapy and Other Types of Physical Therapy for Patients With Neuromuscular Diseases: A Systematic Review

Cited by 166 publications

References 87 publications

Stability and sensitivity of water T₂ obtained with IDEAL‐CPMG in healthy and fat‐infiltrated skeletal muscle

Stability and sensitivity of water T₂ obtained with IDEAL‐CPMG in healthy and fat‐infiltrated skeletal muscle

Neuromuscular Diseases and Rehabilitation

Motor Function Measure Scale (MFM): New Instrument for Follow-Up Brazilian Patients with Neuromuscular Disease

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Exercise Therapy and Other Types of Physical Therapy for Patients With Neuromuscular Diseases: A Systematic Review

Cited by 166 publications

References 87 publications

Stability and sensitivity of water T2 obtained with IDEAL‐CPMG in healthy and fat‐infiltrated skeletal muscle

Stability and sensitivity of water T2 obtained with IDEAL‐CPMG in healthy and fat‐infiltrated skeletal muscle

Neuromuscular Diseases and Rehabilitation

Motor Function Measure Scale (MFM): New Instrument for Follow-Up Brazilian Patients with Neuromuscular Disease

Contact Info

Product

Resources

About

Stability and sensitivity of water T₂ obtained with IDEAL‐CPMG in healthy and fat‐infiltrated skeletal muscle

Stability and sensitivity of water T₂ obtained with IDEAL‐CPMG in healthy and fat‐infiltrated skeletal muscle