Exercise testing in asymptomatic patients with heterozygous familial hypercholesterolaemia

Michaelides, Andreas; Fourlas, Christos A.; Pitsavos, Christos; Andrikopoulos, George; Skoumas, Ioannis; Kartalis, Athanasios; Katsaros, Andreas; Stougiannos, Pavlos; Stefanadis, Christodoulos

doi:10.1097/00019501-200412000-00001

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…December 1, 2015 disease. 78 However, in a larger group of 653 asymptomatic heterozygous FH patients (42% male subjects with an average age of 42 years, 70% using lipid-lowering therapy), a positive stress test was found in 9% of the subjects. 79 Exercise stress tests could also provide prognostic information in asymptomatic heterozygous FH patients.…”

Section: Subclinical Atherosclerosis and Detection Of Myocardial Ischmentioning

confidence: 96%

The Agenda for Familial Hypercholesterolemia

Gidding¹,

Champagne²,

Ferranti³

et al. 2015

Circulation

582

353

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Section: Subclinical Atherosclerosis and Detection Of Myocardial Ischmentioning

confidence: 96%

The Agenda for Familial Hypercholesterolemia

Gidding¹,

Champagne²,

Ferranti³

et al. 2015

Circulation

582

353

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“…C1 (model for untreated data); C2 (model for treated data); TC= Total cholesterol; TG = Triglycerides; LDL-C = Low-density lipoprotein cholesterol; DBP = Diastolic blood pressure; BMI = Body mass index; CHD = Coronary heart disease. xanthomata and corneal arcus were significant factors of FH (Khoo et al, 2000;Michaelides et al, 2004;Scicali et al, 2018). This indicates that patients who have physical symptoms such as corneal arcus and xanthomata more likely (have higher likelihood) to to be classified as FH patient.…”

Section: Discussionmentioning

confidence: 90%

Classification of Familial Hypercholesterolaemia Using Ordinal Logistic Regression

Jamaludin¹,

Wah²,

Nawawi³

et al. 2020

JST

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Familial hypercholesterolaemia (FH) is a genetic disease that causes the elevation of low-density lipoprotein cholesterol (LDL-C), which subsequently leads to premature coronary heart disease (CHD). Features which have been reported to be associated with FH include lipids level, tendon xanthomata, and history of CHD. The Ordinal Logistic Regression model using the classification of FH patients with the Dutch Lipid Clinic Network Criteria (DLCN) as the dependent variable (where 1=Possible, 2=Probable, 3=Definite) was developed and evaluated for different types of link functions. The FH patients (n = 449) were recruited from health screening programmes conducted in hospitals and clinics in Malaysia from 2010 to 2018. Results indicate there is a significant association between FH categories with demographic factors (ethnicity and smoking) and physical symptoms (corneal arcus and xanthomata). The Ordinal Logistic Regression using Cauchit link function has lower Akaike Information Criterion (AIC) value, higher Nagelkerke's R-Square and classification accuracy compared to Probit and Logit link function, diastolic blood pressure, corneal arcus and xanthomata were found to be significant covariates of FH.

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“…154 Outro estudo com 194 indivíduos com HF detectou 21% de testes ergométricos positivos. 155 Apesar de não haver estudos randomizados com teste ergométrico na HF e de os poucos que existem utilizarem critério diagnóstico clínico, a realização de teste ergométrico periodicamente na HFHe pode ser útil para os indivíduos assintomáticos que desejam iniciar atividade física recreativa ou competitiva, bem como para aqueles que apresentam fatores de risco adicional para doença coronariana ou com início de tratamento hipolipemiante tardio, podendo ser repetido a cada 3 a 5 anos (classe IIb, nível de evidência C). Com base nessas informações, podem ser considerados fatores ou marcadores adicionais de risco em portadores de HF os apresentados na Tabela 3. prevenção primária, comparados aos não portadores da doença.…”

Section: Pesquisa De Isquemia Miocárdicaunclassified