Exercise promotes angiogenesis and improves β-adrenergic receptor signalling in the post-ischaemic failing rat heart

Leosco, Dario; Rengo, Giuseppe; Iaccarino, Guido; Galluzzi, Luca; Marchese, M.; Fortunato, Francesca; Zincarelli, Carmela; Sanzari, Emma; Ciccarelli, Michele; Galasso, Gennaro; Altobelli, Giovanna Giuseppina; Conti, Valeria; Matrone, Gianfranco; Cimini, Vincenzo; Ferrara, Nicola; Filippelli, Amelia; Koch, Walter J.; Rengo, F.

doi:10.1093/cvr/cvm109

Cited by 121 publications

(125 citation statements)

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“…us exercise training improves AR responsiveness in hypertension, but the underlying mechanisms have not been fully elucidated. A reduction in GRK2 and calcineurin with training in hypertension have been shown to be mechanistic component of the adaptive response [46,85,105,106] (Figure 2).…”

Section: -Adrenergic Responsivenessmentioning

confidence: 99%

Cardiac Effects of Exercise Training in Hypertension

Libonati

2013

ISRN Hypertension

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Hypertension is a signi�cant health concern. Hypertension leads to compensatory pathologic hypertrophy and impaired cardiac function. Lifestyle modi�cations such as exercise are encouraged for hypertensive patients. Some studies have shown that exercise training can reverse pathological hypertrophy. Conversely, studies on animal models of hypertension have shown increased cardiac growth with exercise training. Despite the further induction of hypertrophy, exercise training seems protective against cell death and may increase cardiomyocyte proliferation, leading to a putative phenotype. �ne of the hallmark bene�cial effects of exercise in hypertension is an improvement in myocardial adrenergic responsiveness. e focus of this paper is to discuss how exercise training impacts cardiac remodeling and function in the hypertensive heart with speci�c reference to adrenergic signaling.

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Section: -Adrenergic Responsivenessmentioning

confidence: 99%

Cardiac Effects of Exercise Training in Hypertension

Libonati

2013

ISRN Hypertension

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“…After myocardial infarction (MI), impaired angiogenesis induces cardiac remodeling characterized by cardiac hypertrophy and fibrosis (5). Dysregulation of cardiac β-adrenergic signaling worsens cardiac remodeling and causes terminal heart failure (5).…”

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confidence: 99%

“…Dysregulation of cardiac β-adrenergic signaling worsens cardiac remodeling and causes terminal heart failure (5). Although left ventricular assist devices or heart transplantation after myocardial infarction (MI) are available for treating patients with terminal heart failure, these therapeutic strategies are limited to a small number of patients and are accompanied with serious complications.…”

mentioning

confidence: 99%

<b>Adipose stem cell sheets improved cardiac function in the rat myocardial infarction, but did not alter cardiac contractile responses to β-adrenergic stim</b><b>ulation </b>

et al. 2015

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Adipose stem cells (ASCs) are a source of regenerative cells available for autologous transplantation to hearts. We compared protective actions of ASC sheets on rat myocardial infarction (MI) in comparison with those of skeletal myoblast cell sheets. Their effects on infarcted hearts were evaluated by biological, histochemical as well as physiological analyses. ASC sheets secreted higher concentrations of angiogenic factors (HGF, VEGF, and bFGF; P < 0.05) under normoxic and hypoxic conditions than those of myoblast cell sheets, associated with reduction of cell apoptosis (P < 0.05). Like myoblast cell sheets, ASC sheets improved cardiac function (P < 0.05) and decreased the plasma level of ANP (P < 0.05) in MI hearts. ASC sheets restored cardiac remodeling characterized by fibrosis, cardiac hypertrophy and impaired angiogenesis (P < 0.05), which was associated with increases in angiogenic factors (P < 0.05). In isolated perfused rat hearts, ASC sheets improved both systolic and diastolic functions, which was comparable to cardiac functions of myoblast cell sheets, while both cell sheets failed to restore cardiac contractile response to either isoproterenol, pimobendan or dibutyryl cAMP. These results indicated that ASC sheets improved cardiac function and remodeling of MI hearts mediated by their paracrine action and this improvement was comparable to those by myoblast cell sheets.

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“…It is still unknown whether these factors might influence tumor progression, apoptosis, and metastasis. Exercise can also promote angiogenesis and knowing that the blood vessel walls contain a variety of stem cells (perivascular endothelial and mural cells) [134][135][136] and some of these stem cells have recently been show to have an inhibitory effect on cancer cells through unknown mechanisms, the beneficial effect of exercise on cancer development and prevention is maybe related to these blood vessel derived cells.…”

Section: Epigenetic Regulationmentioning

confidence: 99%

Untitled

2017

JCPCR

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Potential Mechanisms behind Physical Exercise vs. Epigenetic Regulation for Preventing Breast CancerSubmit Manuscript | http://medcraveonline.com recent years, new applications in both diagnosis and treatment have gradually reduced female breast cancer incidence rates [1]. Considering alternative prevention and therapeutic methods, physical exercise has recently been gaining increased attention in the clinic. Regular exercise appears to lower breast cancer risk by about 10-20 percent, which is a considerable impact from a non-pharmacologic intervention with no cost. Thus, the recently emerging field of exercise-oncology research will be expected to not only clarify the mechanisms behind prevention, but also shed light on future treatment for breast cancer. In this current review, we will summarize recent studies on physical exercise with respect to breast cancer, and discuss their relationship and possible underlying mechanisms. Risk factors for breast cancerBreast cancer is the second most common type of cancer and the leading cause of cancer-related death in women worldwide (link: https://www.breastfriends.org). It is a tremendous disease, affecting lifespan and healthspan. The incidence of breast cancer is increasing every year, and an estimated 252,710 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S. in 2017 (link: http://www.breastcancer.org/symptoms/ understand_bc/statistics). Throughout the world, every year more than 400,000 deaths are caused by breast cancer and, out of these diagnosed cases, there are more than 2.8 million breast cancer survivors [2].Generally, there are two aspects of risk factors for breast cancer (see Table1): (1) [68][69][70]. On the other hand, due to genetic susceptibility influences, which are inherited and unchangeable; the non-modifiable factors are not easily controllable risks for breast cancer. Therefore, it is feasible to reduce the risk factors that are not inherited, but can be changed. Among these modifiable risk factors, physical exercise behaviors not only are beneficial for preventing all stages of cancer development [71], but also are helpful to maintain a healthy weight and reduce risks for developing other diseases, such as cardiovascular disease, diabetes, and stroke [72]. Furthermore, physical activity (PA) has been increasingly regarded as the nonpharmacologic intervention for many cancer patients to combat both the physiologic and psychological effects of cancer treatment [73]. A recent World Health Organization (WHO) report shows that physical inactivity remains one of the most important risk factors for total cancer related mortality (responsible for 6% of total deaths) along with overweight and obesity (responsible for another 5%) [74]. AbstractBreast cancer is the most commonly diagnosed cancer and has been the second leading cause of death due to cancer among women worldwide. It is a disease in which malignant (cancer) cells form in the tissues of the breast and become deadly when they metastasize, spreading to oth...

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Exercise promotes angiogenesis and improves β-adrenergic receptor signalling in the post-ischaemic failing rat heart

Abstract: Our data indicate that exercise favourably affects angiogenesis and improves LV remodelling and contractility reserve in a rat model of severe chronic HF.

Cited by 121 publications

References 41 publications

Cardiac Effects of Exercise Training in Hypertension

Cardiac Effects of Exercise Training in Hypertension

<b>Adipose stem cell sheets improved cardiac function in the rat myocardial infarction, but did not alter cardiac contractile responses to β-adrenergic stim</b><b>ulation </b>

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