Exercício contínuo e intermitente: Efeitos do treinamento e do destreinamento sobre o peso corporal e o metabolismo muscular de ratos obesos

Braga, Larissa; Mello, María Alice Rostom de; Manchado, Fúlvia de Barros; Gobatto, Cláudio Alexandre

doi:10.5628/rpcd.06.02.160

Cited by 13 publications

(21 citation statements)

References 35 publications

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“…Braga et al (23) buscaram identificar a resposta do exercício físico durante programas de treinamento continuo e intermitente em ratos obesos submetidos ao tratamento com MSG. Verificaram que a atividade física reduziu os teores de gordura da carcaça em ambos os treinamentos.…”

Section: Discussionunclassified

Máxima Fase estável de lactato em ratos obesos de ambos os gêneros

Araújo

D'Angelo

et al. 2009

Rev Bras Med Esporte

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A incidência de obesidade vem crescendo entre a população mundial, levando a inúmeras complicaçõe,s como risco de doenças crônico-degenerativas. Por outro lado, o exercício físico tem sido empregado isoladamente ou em associação a dieta, no tratamento dessa doença. Assim, pesquisas envolvendo exercício são imprescindíveis para evolução no tratamento e controle da obesidade. O objetivo deste estudo foi identificar a intensidade de exercício equivalente à transição metabólica aeróbio-anaeróbia em ratos Wistar obesos de ambos os gêneros, por tratamento com glutamato monossódico (MSG), utilizando o protocolo de máxima fase estável de lactato (MFEL). Para isso, foram testados 40 ratos adultos subdivididos em quatro grupos com 10 animais cada um: controle machos, controle fêmeas, obeso machos e obeso fêmeas. Depois de adequada adaptação (três semanas) ao exercício em meio líquido (31 ± 1ºC) os animais foram submetidos a teste de natação (25 min) suportando sobrecargas contínua e aleatória correspondentes a 4,5 -5,0 -5,5 -6,0 e 6,5% do peso corporal (PC), com intervalo de 72 horas entre elas. Os animais dos grupos obesos tiveram aumentos no peso do tecido adiposo subcutâneo, mesentérico e retroperitonial em relação aos grupos controle. O índice de Lee foi maior nos animais obesos em comparação com os controles. Foi possível identificar a MFEL a 6,0% do PC nos dois grupos obesos. Para o grupo controle fêmea, a MFEL esteve por volta de 5,0% do PC enquanto que nos controle macho a 4,5% do PC. Desse modo pode-se concluir que a obesidade induzida por MSG interfere na cinética de lactato durante o exercício em ambos os sexos, alterando a intensidade de esforço referente à transição metabólica.Palavras-chave: obesidade, capacidade aeróbia, hipotálamo. ABstrActThe purpose of this study was to identify the exercise intensity equivalent to the aerobic/anaerobic metabolic transition in obese rats of both genders using the maximal lactate steady state (MLSS) protocol. Four groups of rats were tested on MLSS protocol (swimming exercise): male control n=10, female control n=10, male obese n=10 and female obese n=10, after suitable adaptation to exercise in liquid medium and obesity induction by monossodic glutamate (MSG) administration. The obese groups had significant increase in subcutaneous adipose tissue as well as mesenteric and retroperitoneal fat depots comparing to the control groups. The Lee index was higher in the obese animals in comparison to their respective controls. It was possible to identify the MLSS at 6.0% of body weight for both obese groups. Concerning the female control group, the MLSS was determined at the intensity of 5.0% of body weight, whereas for the male control at 4.5% of body weight. It was concluded that obesity induced by MSG interferes in lactate kinetics during exercise and alters the effort intensity corresponding to the metabolic transition in both genders.Keywords: obesity, aerobic capacity, hypothalamus. introdUÇÃo A obesidade é provavelmente uma das enfermidades mais antigas que acometem o hom...

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Section: Discussionunclassified

Máxima Fase estável de lactato em ratos obesos de ambos os gêneros

Araújo

D'Angelo

et al. 2009

Rev Bras Med Esporte

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“…Data referring to body weight alterations in rats induced to obesity by the neonatal MSG administration are controversial 7,8 and previous studies by this research group have evidenced no weight gain alteration in those animals. However, MSG animals are known to have a reduced secretion of growth hormone 9 and an increased secretion of cortisol, 10 and, thus, the weight gain in MSG and MSG+CAF animals is mainly due to the increase in visceral fat. Although the animals receiving the hypercaloric diet did not have an increase in body weight, they also had an increase in visceral fat.…”

Section: Discussionmentioning

confidence: 99%

Efeito da associação entre obesidade neuroendócrina e exócrina experimental sobre a pressão arterial de cauda e o metabolismo de glicose de ratos Wistar

Pastore¹,

Cesaretti²,

Ginoza³

et al. 2010

J. Bras. Nefrol.

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Objective: To study two different models of obesity, exocrine and endocrine, and its association on tail arterial pressure (TAP), body weight (BW), glucose metabolism and visceral fat content. Methods: Male Wistar rats were studied. The MSG group was composed by rats that received of MSG in neonatal period. At the 3rd month of life, part of these animals received cafeteria diet. Animals received saline control in the neonatal period. In the 12 weeks of study, body weight and blood pressure were measured twice a week. In the end of this period on, Oral Glucose Tolerance Test (OGTT) was performed and the Insulin Sensitivity Index (ISI) was calculated, also the left Relative Ventricular Weight (RLW) and Relative Epididimal Fat Weight (REFW) were obtained. Results: No changes on BW and TAP were verified. The obesity induced by MSG and CAF, individually, let to increases on insulin resistance (WST = 23,25 ± 9,31; CAF = 15,92 ± 9,10*; MSG = 13,41 ± 3,84* mg-1mU-1, p < 0,05 vs WST) and relative epididimal fat content (WST = 6,20 ± 0,57; CAF = 8,27 ± 1,53*; MSG = 8,23 ± 1,98* g/100 g, *p < 0,05) when these rats were compared to control rats. An enhanced effect upon these parameters was observed with the association of both obesity models (MSG+CAF = 9,34 ± 5,77 mg1mU-1, p < 0,05 vs MSG and CAF) and visceral fat content (MSG+CAF = 11,12 ± 3,85 g/100g, p < 0,05 vs MSG and CAF). Conclusion: The association of these two experimental models of obesity aggravates insulin resistance that probably is due at least in part to the increase of visceral fat content.

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“…The interval training protocol was based on the model proposed by Braga et al 13 with minor modifications. The training was carried out in a swimming pool apparatus with temperature maintained between 30 and 32°C.…”

Section: Interval Training Protocolmentioning

confidence: 99%

Interval Training Is Insufficient to Attenuate Metabolic Disturbances in Diabetic Rats

Rocha

Nunes

Venera

et al. 2016

Rev Bras Med Esporte

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Introduction: Type 1 diabetes is a metabolic disease associated to blood disturbances and disorder of the innate immune system functionality. Objective: This study investigated the effect of two weeks interval training on blood biochemistry and immunological parameters in rats with type 1 diabetes. Methods: Male Wistar rats were divided into three groups: sedentary (SE, n = 10), diabetic sedentary (DI, n = 10), diabetic interval training (DIT, n = 10). IV injection of streptozotocin (45 mg/kg) induced diabetes. Interval training consisted of swimming exercise for 30 seconds with 30 seconds of rest for 30 minutes three times a week during two weeks, with an overload of 15% of the total body mass. The evaluations performed were fasting blood glucose, triglycerides, very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and total cholesterol concentrations, phagocytic capacity, cationic vesicles content, superoxide anion, and production of hydrogen peroxide of blood neutrophils and peritoneal macrophages. Results: The results showed that two weeks interval training did not attenuate the hyperglycemic state at rest and did not decrease blood lipids in the DIT group. Diabetes increased the functionality of blood neutrophils and peritoneal macrophages in the DI group. Interval training increased the content of cationic vesicles and the phagocytic capacity of blood neutrophils and peritoneal macrophages in the DIT group. Conclusion: It was found that two weeks of interval training increased the functionality parameters of innate immune cells, although this has been insufficient to attenuate the biochemical disorders caused by diabetes.

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Exercício contínuo e intermitente: Efeitos do treinamento e do destreinamento sobre o peso corporal e o metabolismo muscular de ratos obesos

Cited by 13 publications

References 35 publications

Máxima Fase estável de lactato em ratos obesos de ambos os gêneros

Máxima Fase estável de lactato em ratos obesos de ambos os gêneros

Efeito da associação entre obesidade neuroendócrina e exócrina experimental sobre a pressão arterial de cauda e o metabolismo de glicose de ratos Wistar

Interval Training Is Insufficient to Attenuate Metabolic Disturbances in Diabetic Rats

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