Excitotoxic lesions of the parafascicular nucleus produce deficits in a socially transmitted food preference

Quiroz‐Padilla, María Fernanda; Guillazo-Blanch, Gemma; Vale-Martínez, Anna; Martí-Nicolovius, Margarita

doi:10.1016/j.nlm.2006.03.007

Cited by 17 publications

(10 citation statements)

References 39 publications

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“…These studies, together with our data, support the notion that a parkinsonian gain-of-function of intralaminar thalamus contributes to basal ganglia pathophysiology in PD (Chen et al, 2014). Indeed, CM/Pf inactivation using hM4D or eArch3.0 showed no effect in control animals, consistent with previous studies that found no effect of CM/Pf lesion on spontaneous motor behavior (Henderson et al, 2005; Quiroz-Padilla et al, 2006). Thus, the normal role of CM/Pf may be in sensory-driven rather than internally-driven behavior (Matsumoto et al, 2001; Minamimoto et al, 2005).…”

Section: Discussionsupporting

confidence: 91%

Pathway-Specific Remodeling of Thalamostriatal Synapses in Parkinsonian Mice

Parker

Lalive

Kreitzer

2016

Neuron

118

124

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SUMMARY Movement suppression in Parkinson’s disease (PD) is thought to arise from increased efficacy of the indirect pathway basal ganglia circuit, relative to the direct pathway. However, the underlying pathophysiological mechanisms remain elusive. To examine whether changes in the strength of synaptic inputs to these circuits contribute to this imbalance, we obtained paired whole-cell recordings from striatal direct- and indirect-pathway medium spiny neurons (dMSNs and iMSNs) and optically stimulated inputs from sensorimotor cortex or intralaminar thalamus in brain slices from control and dopamine-depleted mice. We found that dopamine depletion selectively decreased synaptic strength at thalamic inputs to dMSNs, suggesting that thalamus drives asymmetric activation of basal ganglia circuitry underlying parkinsonian motor impairments. Consistent with this hypothesis, in vivo chemogenetic and optogenetic inhibition of thalamostriatal terminals reversed motor deficits in dopamine-depleted mice. These results implicate thalamostriatal projections in the pathophysiology of PD and support interventions targeting thalamus as a potential therapeutic strategy.

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Section: Discussionsupporting

confidence: 91%

Pathway-Specific Remodeling of Thalamostriatal Synapses in Parkinsonian Mice

Parker

Lalive

Kreitzer

2016

Neuron

118

124

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“…Although the outcome of DCS only affecting the 24 h test, as opposed to acquisition, may be unexpected, it rules out the possibility of a state-dependent learning situation. Moreover, it has previously been shown that PLC SCOP infusions or thalamic lesions carried out prior to ODT acquisition may result in delayed effects [29], [49]. As for the STFP task, involvement of the NMDA receptors has previously been demonstrated in experiments administering NMDAR antagonists systemically or in the hippocampus, inducing amnesic effects [62], [63].…”

Section: Discussionmentioning

confidence: 99%

“…To rule out olfactory alterations due to the DCS and SCOP infusions, an additional olfactory perception test was conducted at the end of the experiment [48], [49] on a sample of each group (VEH: n = 8, DCS: n = 8, SCOP: n = 8 and DCS+SCOP: n = 9). Twenty-four hours before the olfactory test, the rats were habituated to butter-flavored cookies (Brambly Hedge, Denmark).…”

Section: Methodsmentioning

confidence: 99%

D-cycloserine in Prelimbic Cortex Reverses Scopolamine-Induced Deficits in Olfactory Memory in Rats

et al. 2013

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A significant interaction between N-methyl-D-aspartate (NMDA) and muscarinic receptors has been suggested in the modulation of learning and memory processes. The present study further investigates this issue and explores whether d-cycloserine (DCS), a partial agonist at the glycine binding site of the NMDA receptors that has been regarded as a cognitive enhancer, would reverse scopolamine (SCOP)-induced amnesia in two olfactory learning tasks when administered into the prelimbic cortex (PLC). Thus, in experiment 1, DCS (10 µg/site) was infused prior to acquisition of odor discrimination (ODT) and social transmission of food preference (STFP), which have been previously characterized as paradigms sensitive to PLC muscarinic blockade. Immediately after learning such tasks, SCOP was injected (20 µg/site) and the effects of both drugs (alone and combined) were tested in 24-h retention tests. To assess whether DCS effects may depend on the difficulty of the task, in the STFP the rats expressed their food preference either in a standard two-choice test (experiment 1) or a more challenging three-choice test (experiment 2). The results showed that bilateral intra-PLC infusions of SCOP markedly disrupted the ODT and STFP memory tests. Additionally, infusions of DCS alone into the PLC enhanced ODT but not STFP retention. However, the DCS treatment reversed SCOP-induced memory deficits in both tasks, and this effect seemed more apparent in ODT and 3-choice STFP. Such results support the interaction between the glutamatergic and the cholinergic systems in the PLC in such a way that positive modulation of the NMDA receptor/channel, through activation of the glycine binding site, may compensate dysfunction of muscarinic neurotransmission involved in stimulus-reward and relational learning tasks.

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“…To rule out olfactory alterations due to the scopolamine infusions, an additional olfactory perception test was conducted at the end of the experiment (Wrenn et al 2003;Quiroz-Padilla et al 2006) on a sample of each group (SCOP20, n = 10; SCOP5, n = 8; and VEH, n = 9). Twenty-four hours before the olfactory test, rats were habituated to butter-flavored cookies (Brambly Hedge).…”

Section: Olfactory Perception Testmentioning

confidence: 99%

Differential effects of muscarinic receptor blockade in prelimbic cortex on acquisition and memory formation of an odor-reward task

Carballo-Márquez¹,

Vale-Martínez²,

Guillazo-Blanch³

et al. 2007

Learn. Mem.

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The present experiments determined the consequences of blocking muscarinic cholinergic receptors of the prelimbic (PL) cortex in the acquisition and retention of an odor-reward associative task. Rats underwent a training test (five trials) and a 24-h retention test (two retention trials and two relearning trials). In the first experiment, rats were bilaterally infused with scopolamine (20 or 5 µg/site) prior to training. Although scopolamine rats showed acquisition equivalent to PBS-injected controls, they exhibited weakened performance in the 24-h retention test measured by number of errors. In the second experiment, rats were injected with scopolamine (20 µg/site) immediately or 1 h after training and tested 24 h later. Scopolamine rats injected immediately showed severe amnesia detected in two performance measures (errors and latencies), demonstrating deficits in retention and relearning, whereas those injected 1 h later showed good 24-h test performance, similar to controls. These results suggest that muscarinic transmission in the PL cortex is essential for early memory formation, but not for acquisition, of a rapidly learned odor discrimination task. Findings corroborate the role of acetylcholine in consolidation processes and the participation of muscarinic receptors in olfactory associative tasks.

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Excitotoxic lesions of the parafascicular nucleus produce deficits in a socially transmitted food preference

Cited by 17 publications

References 39 publications

Pathway-Specific Remodeling of Thalamostriatal Synapses in Parkinsonian Mice

Pathway-Specific Remodeling of Thalamostriatal Synapses in Parkinsonian Mice

D-cycloserine in Prelimbic Cortex Reverses Scopolamine-Induced Deficits in Olfactory Memory in Rats

Differential effects of muscarinic receptor blockade in prelimbic cortex on acquisition and memory formation of an odor-reward task

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