Exceptional biocompatibility of 3D fibrous scaffold for cardiac tissue engineering fabricated from biodegradable polyurethane blended with cellulose

Su, Wei‐Fang; Ho, Chih‐Hsiang; Shih, Tzu-Hsiang; Wang, Chen-Hua; Yeh, Chun-Hao

doi:10.1080/00914037.2016.1157802

Cited by 17 publications

(13 citation statements)

References 32 publications

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“…However, few of the major drawbacks associated with the fibres made from poly(urethane) include intertwining and stickiness. This issue has been solved by the Wei-Fang Su et al approach in which they blended rigid cellulose into poly(urethane) made from aromatic diisocyanate and polyether diol [ 82 ]. Poly(urethane) fibres are non-biodegradable.…”

Section: Biomaterialsmentioning

confidence: 99%

Emergence of Three Dimensional Printed Cardiac Tissue: Opportunities and Challenges in Cardiovascular Diseases

Charbe

Zacconi

Amnerkar

et al. 2019

CCR

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Three-dimensional (3D) printing, also known as additive manufacturing, was developed originally for engineering applications. Since its early advancements, there has been a relentless development in enthusiasm for this innovation in biomedical research. It allows for the fabrication of structures with both complex geometries and heterogeneous material properties. Tissue engineering using 3D bio-printers can overcome the limitations of traditional tissue engineering methods. It can match the complexity and cellular microenvironment of human organs and tissues, which drives much of the interest in this technique. However, most of the preliminary evaluations of 3Dprinted tissues and organ engineering, including cardiac tissue, relies extensively on the lessons learned from traditional tissue engineering. In many early examples, the final printed structures were found to be no better than tissues developed using traditional tissue engineering methods. This highlights the fact that 3D bio-printing of human tissue is still very much in its infancy and more work needs to be done to realise its full potential. This can be achieved through interdisciplinary collaboration between engineers, biomaterial scientists and molecular cell biologists. This review highlights current advancements and future prospects for 3D bio-printing in engineering ex vivo cardiac tissue and associated vasculature, such as coronary arteries. In this context, the role of biomaterials for hydrogel matrices and choice of cells are discussed. 3D bio-printing has the potential to advance current research significantly and support the development of novel therapeutics which can improve the therapeutic outcomes of patients suffering fatal cardiovascular pathologies.

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Section: Biomaterialsmentioning

confidence: 99%

Emergence of Three Dimensional Printed Cardiac Tissue: Opportunities and Challenges in Cardiovascular Diseases

Charbe

Zacconi

Amnerkar

et al. 2019

CCR

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“…Polyurethane, unless copolymerized, is biocompatible but not biodegradable. Polyurethane has been successfully experimented in combination with other materials for cardiac tissue repair, such as siloxane films ( Hashi et al, 2007 ; Baheiraei et al, 2015 ), cellulose ( Baheiraei et al, 2016 ), urea ( Su et al, 2016 ), PLLA ( Hernández-Córdova et al, 2016 ). Poly (ε- caprolactone) in combination with other biomaterials have also been proven to be efficient composite for cardiac tissue repair.…”

Section: Congenital Heart Disease: Types Malformations Presentationmentioning

confidence: 99%

Recent advances and challenges on application of tissue engineering for treatment of congenital heart disease

Mantakaki¹,

Fakoya

Sharifpanah

2018

PeerJ

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Congenital heart disease (CHD) affects a considerable number of children and adults worldwide. This implicates not only developmental disorders, high mortality, and reduced quality of life but also, high costs for the healthcare systems. CHD refers to a variety of heart and vascular malformations which could be very challenging to reconstruct the malformed region surgically, especially when the patient is an infant or a child. Advanced technology and research have offered a better mechanistic insight on the impact of CHD in the heart and vascular system of infants, children, and adults and identified potential therapeutic solutions. Many artificial materials and devices have been used for cardiovascular surgery. Surgeons and the medical industry created and evolved the ball valves to the carbon-based leaflet valves and introduced bioprosthesis as an alternative. However, with research further progressing, contracting tissue has been developed in laboratories and tissue engineering (TE) could represent a revolutionary answer for CHD surgery. Development of engineered tissue for cardiac and aortic reconstruction for developing bodies of infants and children can be very challenging. Nevertheless, using acellular scaffolds, allograft, xenografts, and autografts is already very common. Seeding of cells on surface and within scaffold is a key challenging factor for use of the above. The use of different types of stem cells has been investigated and proven to be suitable for tissue engineering. They are the most promising source of cells for heart reconstruction in a developing body, even for adults. Some stem cell types are more effective than others, with some disadvantages which may be eliminated in the future.

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“…The EPUSF were nontoxic and did not alter the intrinsic electrical characteristics of HL-1 cells [ 150 ]. 3D biomimetic scaffolds using a polymer blend of polyurethane and cellulose were also reported to have good biocompatibility, provided good mechanical support, and housed frequent contraction cycles of cardiac tissue [ 151 ]. Soft polyurethane-urea scaffolds with regular tubular pores were also observed to withstand tensile stresses associated with diastole without opposing tissue contraction.…”

Section: Biomaterials For Cardiac Regenerationmentioning

confidence: 99%

Current Trends in Biomaterial Utilization for Cardiopulmonary System Regeneration

Fakoya

Otohinoyi

Yusuf

2018

Stem Cells International

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The cardiopulmonary system is made up of the heart and the lungs, with the core function of one complementing the other. The unimpeded and optimal cycling of blood between these two systems is pivotal to the overall function of the entire human body. Although the function of the cardiopulmonary system appears uncomplicated, the tissues that make up this system are undoubtedly complex. Hence, damage to this system is undesirable as its capacity to self-regenerate is quite limited. The surge in the incidence and prevalence of cardiopulmonary diseases has reached a critical state for a top-notch response as it currently tops the mortality table. Several therapies currently being utilized can only sustain chronically ailing patients for a short period while they are awaiting a possible transplant, which is also not devoid of complications. Regenerative therapeutic techniques now appear to be a potential approach to solve this conundrum posed by these poorly self-regenerating tissues. Stem cell therapy alone appears not to be sufficient to provide the desired tissue regeneration and hence the drive for biomaterials that can support its transplantation and translation, providing not only physical support to seeded cells but also chemical and physiological cues to the cells to facilitate tissue regeneration. The cardiac and pulmonary systems, although literarily seen as just being functionally and spatially cooperative, as shown by their diverse and dissimilar adult cellular and tissue composition has been proven to share some common embryological codevelopment. However, necessitating their consideration for separate review is the immense adult architectural difference in these systems. This review also looks at details on new biological and synthetic biomaterials, tissue engineering, nanotechnology, and organ decellularization for cardiopulmonary regenerative therapies.

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Exceptional biocompatibility of 3D fibrous scaffold for cardiac tissue engineering fabricated from biodegradable polyurethane blended with cellulose

Cited by 17 publications

References 32 publications

Emergence of Three Dimensional Printed Cardiac Tissue: Opportunities and Challenges in Cardiovascular Diseases

Emergence of Three Dimensional Printed Cardiac Tissue: Opportunities and Challenges in Cardiovascular Diseases

Recent advances and challenges on application of tissue engineering for treatment of congenital heart disease

Current Trends in Biomaterial Utilization for Cardiopulmonary System Regeneration

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