Examining the association between obstructive sleep apnea and cardiometabolic risk factors in the elderly

Wu, Chen‐Jung; Kao, Tung‐Wei; Chang, Yaotsu; Chen, Wei‐Liang

doi:10.1007/s41105-018-0145-y

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…OSA is also a risk factor for cardiovascular diseases (e.g., atherosclerosis) as well as type 2 diabetes [70,71]. IH could cause not only pulmonary vascular disease but also systemic vascular diseases.…”

Section: Effects Of Intermittent Hypoxia On Systemic Diseasesmentioning

confidence: 99%

Effects of Intermittent Hypoxia on Pulmonary Vascular and Systemic Diseases

Kimura

Ota

Kimura

et al. 2019

IJERPH

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Obstructive sleep apnea (OSA) causes many systemic disorders via mechanisms related to sympathetic nerve activation, systemic inflammation, and oxidative stress. OSA typically shows repeated sleep apnea followed by hyperventilation, which results in intermittent hypoxia (IH). IH is associated with an increase in sympathetic activity, which is a well-known pathophysiological mechanism in hypertension and insulin resistance. In this review, we show the basic and clinical significance of IH from the viewpoint of not only systemic regulatory mechanisms focusing on pulmonary circulation, but also cellular mechanisms causing lifestyle-related diseases. First, we demonstrate how IH influences pulmonary circulation to cause pulmonary hypertension during sleep in association with sleep state-specific change in OSA. We also clarify how nocturnal IH activates circulating monocytes to accelerate the infiltration ability to vascular wall in OSA. Finally, the effects of IH on insulin secretion and insulin resistance are elucidated by using an in vitro chamber system that can mimic and manipulate IH. The obtained data implies that glucose-induced insulin secretion (GIS) in pancreatic β cells is significantly attenuated by IH, and that IH increases selenoprotein P, which is one of the hepatokines, as well as TNF-α, CCL-2, and resistin, members of adipokines, to induce insulin resistance via direct cellular mechanisms. Clinical and experimental findings concerning IH give us productive new knowledge of how lifestyle-related diseases and pulmonary hypertension develop during sleep.

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Section: Effects Of Intermittent Hypoxia On Systemic Diseasesmentioning

confidence: 99%

Effects of Intermittent Hypoxia on Pulmonary Vascular and Systemic Diseases

Kimura

Ota

Kimura

et al. 2019

IJERPH

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“…Another study looked at associations between OSA and metabolic syndrome (MetS), including different components of MetS in adults, which are common chronic conditions associated with cardiovascular (CV) morbidity and mortality. 312 Data were gathered from the 2007-2008 National Health and Nutrition Examination Survey, which included 5909 individuals aged 20 years (2898 men, 3011 women), who had undergone a complete medical examination and had self-reported 3 OSA symptoms. The primary outcome was possible OSA (pOSA) and MetS components.…”

Section: Pathophysiology and Medical Implicationsmentioning

confidence: 99%

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Cagna

Donovan

McKee³

et al. 2019

The Journal of Prosthetic Dentistry

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Impact of sleep-disordered breathing on glucose metabolism among individuals with a family history of diabetes: the Nagahama study

Minami

Matsumoto

Tabara

et al. 2021

Journal of Clinical Sleep Medicine

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Study Objectives: It is well known that a family history of diabetes (FHD) is a definitive risk factor for type 2 diabetes. It has not been known whether sleep disordered breathing (SDB) increases the prevalence of diabetes in those with FHD. Methods:We assessed SDB severity in 7,477 study participants by oximetry corrected by objective sleep duration determined by wrist actigraphy. HbA1c ≥6.5% and/or current medication for diabetes indicated the presence of diabetes. In addition to the overall prevalence, the prevalence of recent-onset diabetes during the almost 5 years before the SDB measurements was investigated.Results: Of the 7,477 participants (mean age 57.9 [range 34.2-80.7, SD 12.1] years, females 67.7%), 1,569 had FHD. The prevalence of diabetes in FHD participants with moderate-to-severe SDB (MS-SDB) was higher than in those without SDB (MS-SDB vs.

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Examining the association between obstructive sleep apnea and cardiometabolic risk factors in the elderly

Cited by 3 publications

References 37 publications

Effects of Intermittent Hypoxia on Pulmonary Vascular and Systemic Diseases

Effects of Intermittent Hypoxia on Pulmonary Vascular and Systemic Diseases

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Impact of sleep-disordered breathing on glucose metabolism among individuals with a family history of diabetes: the Nagahama study

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