Impact of sleep-disordered breathing on glucose metabolism among individuals with a family history of diabetes: the Nagahama study

Abstract

Study Objectives: It is well known that a family history of diabetes (FHD) is a definitive risk factor for type 2 diabetes. It has not been known whether sleep disordered breathing (SDB) increases the prevalence of diabetes in those with FHD. Methods:We assessed SDB severity in 7,477 study participants by oximetry corrected by objective sleep duration determined by wrist actigraphy. HbA1c ≥6.5% and/or current medication for diabetes indicated the presence of diabetes. In addition to the overall prevalence, the prevalence of recent-onset diabetes during the almost 5 years before the SDB measurements was investigated.Results: Of the 7,477 participants (mean age 57.9 [range 34.2-80.7, SD 12.1] years, females 67.7%), 1,569 had FHD. The prevalence of diabetes in FHD participants with moderate-to-severe SDB (MS-SDB) was higher than in those without SDB (MS-SDB vs.

Transcriptomic Changes of Murine Visceral Fat Exposed to Intermittent Hypoxia at Single Cell Resolution

“…The pathophysiology of the cardiometabolic complications in OSA is still incompletely understood; however, intermittent hypoxia (IH) as observed in OSA, and characterized by repetitive short cycles of oxyhemoglobin desaturation and reoxygenation, likely plays a pivotal role. Furthermore, emerging evidence of a relationship between OSA and metabolic perturbations, and in particular with alterations in glucose metabolism such as insulin resistance (IR) and type 2 diabetes (T2D) has been reproducibly reported across a multitude of studies [4][5][6][7][8][9][10][11][12][13][14][15], including in healthy volunteers [16][17][18]. To elucidate the potential mechanisms implicated in such metabolic derangements, murine models have been developed that traditionally include one of the major perturbations of OSA, namely IH [1,19,20].…”