Examination of the Utility of the Rat as an Animal Model for Human Anticoagulation

Smith, Lawrence J.; Schaible, Keith; Fessler, Richard G.; Rachlin, Jacob; Brown, Frederick D.

doi:10.1159/000215745

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…The rat has been shown to serve as an appropriate model for investigating the effects of heparin, with results applicable to humans. 17 Current clinical practice targets an aPTT value of 1.5 to 3.0 times baseline values as the goal for adequate anticoagulation, whereas the ideal dosing for LMWH has been less clearly defined. In our current study, adequate anticoagulation was achieved in both high-dose SH and high-dose LMWH groups.…”

Section: Discussionmentioning

confidence: 99%

Low-dose low–molecular-weight heparin is anti-inflammatory during venous thrombosis

Downing

Strieter

Kadell

et al. 1998

Journal of Vascular Surgery

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Although both SH and LMWH inhibited vein wall neutrophils and total inflammatory cells, low-dose LMWH was most effective limiting neutrophil extravasation and was the only intervention to decrease VP below control levels. This occurred without preventing thrombus formation or causing a state of anticoagulation. Low-dose LMWH possesses anti-inflammatory properties distinct from its anticoagulant properties.

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Section: Discussionmentioning

confidence: 99%

Low-dose low–molecular-weight heparin is anti-inflammatory during venous thrombosis

Downing

Strieter

Kadell

et al. 1998

Journal of Vascular Surgery

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“…[26,27] Thus, in the present study we used heparin at 300 IU Á kg À1 . Typically, only measures of blood loss and hemostatic time are used for evaluating the hemostatic efficacy of a hemostatic agent in these models.…”

Section: Surgical Kidney Injury Modelmentioning

confidence: 99%

Hemostatic Efficacy of Biological Self‐Assembling Peptide Nanofibers in a Rat Kidney Model

Sui

Zhang

Wang

2009

Macromolecular Bioscience

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We evaluated the hemostatic efficacy of a biological self-assembling peptide RADA16-I in a rat kidney injury model. Adult male rats were randomized into five groups: sham operation (no renal excision), no hemostatic agent (control), commercially available gelatin sponge (Gelfoam), 1% RADA16-I, and 2% RADA16-I. After left partial nephrectomy, the anesthetized animal was anticoagulated using 300 IU x kg(-1) heparin, and the topical hemostatic agent was applied to the injury. Blood loss and mean arterial pressure (MAP) were recorded. As was the case for Gelfoam, 2% RADA16-I produced marked hemostasis versus controls (p < 0.01). Blood loss with 1% and 2% RADA16-I was significantly less than controls. The decline in MAP during surgery was less with 2% versus 1% RADA16-I. RADA16-I also resulted in less histological tissue responses than Gelfoam. These data suggest that RADA16-I can stop hemorrhage, with only minimal tissue responses, in experimental renal injury.

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“…The mean administered dose of 174 ± 15 IU heparin was applied to prevent clotting of the arterial catheter, but was not sufficient for systemic full-dose anticoagulation in rats. 22 Heparinization in therapeutic dosage might have prevented the formation of stenosis, but is not applicable in all experimental settings, and was therefore not applied in our study.…”

Section: Discussionmentioning

confidence: 99%

Closing microvascular lesions with fibrin sealant-attached muscle pads

et al. 2005

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Fibrin sealants are used in a variety of surgical procedures, mainly for purposes of hemostasis and assisted wound healing. The combined use of fibrin sealant and autologous muscle pads for hemostasis was not reported previously. Arterial incisions in the common carotid artery in rats were closed by the combined application of fibrin sealant and an autologous muscle pad. Postsurgical vessel patency and degree of stenosis were evaluated by color duplex sonography, computed tomography angiography, and postmortem histology. The combined application of muscle pad and fibrin sealant and achievement of hemostasis was feasible in all animals. Seventy-eight percent of animals showed no or only slight postsurgical vessel stenosis. Our method is simple and quick to perform, showing a high potential for hemostasis in microvascular lesions. Therefore, it might be used in future experimental studies for conservation of vessel patency after arterial catheterization and in experimental or clinical vascular surgery.

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Examination of the Utility of the Rat as an Animal Model for Human Anticoagulation

Cited by 7 publications

References 5 publications

Low-dose low–molecular-weight heparin is anti-inflammatory during venous thrombosis

Low-dose low–molecular-weight heparin is anti-inflammatory during venous thrombosis

Hemostatic Efficacy of Biological Self‐Assembling Peptide Nanofibers in a Rat Kidney Model

Closing microvascular lesions with fibrin sealant-attached muscle pads

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