“…113 The group utilised Longa's 42 transient iMCAO method in rats, with both filament insertion and MSC injection via a transected ECA, with the CCA temporarily tied for the duration of iMCAO. 113 CCA repair, reported previously to be successful in rats, 114,115 alongside our recent method development in mice, 101,105 would negate the requirement to transect the ECA, therefore, removing the negative welfare outcomes reported following ECA transection. 102,103,114 Although many IA stem cell delivery experimental models utilise rats, there are examples of these studies conducted in mice.…”