Examination of fetal nasal bone and repeatability of measurement in early pregnancy

Kanellopoulos, V.; Katsetos, Christos; Economides, D. L.

doi:10.1002/uog.177

Cited by 37 publications

(36 citation statements)

References 8 publications

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“…However, our mean NBL findings differ negatively at the 11 th , 12 th and 13 rd gestational weeks from some of these studies (12,22,23) and positively from some others (19,23). This difference might be due to ethnical difference (25) as well as interobserver and intraobserver variability in the measurement of length of the nasal bone (11,13,14). Variations may also be due to the quality of the machine as well, however it seems to be difficult to compare all these previous studies in this sense as most had different brand types of sonographic devices (12,(20)(21)(22)(23)(24).…”

Section: Discussioncontrasting

confidence: 53%

“…Evaluation of the nasal bone has been suggested to improve the performance of first-trimester screening for trisomy 21 (3)(4)(5)(6)(7)(8)(9). Experience has been shown to be an important factor for the use of the nasal bone as an additional sonographic marker in first trimester screening (10)(11)(12)(13)(14). In most of the previous studies determining the presence of nasal bone for screen- (4,8,(14)(15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

“…The evaluation of the nasal bone has been also shown to improve the performance of first-trimester screening for trisomy 21 (9). However, interobserver and intraobserver variability is a limitation for the measurement of length of the nasal bone and experience was shown to be important in the use of the nasal bones as an additional sonographic marker in first trimester screening (10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

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Normative values of fetal nasal bone lengths of Turkish singleton pregnancies in the first trimester

Yayla¹,

Ergin²,

Göynümer³

2011

J Turkish German Gynecol Assoc

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Objective: Evaluation of nasal bone improves the performance of firsttrimester screening for trisomy 21. In this retrospective study we aimed to determine normative values related to the measurement of nasal bone length of the Turkish population during the first trimester ultrasonographic fetal screening. Material and Methods:Medical records of singleton pregnancies, whose first trimester fetal screening was performed between 2004 and 2010, were evaluated retrospectively. Pregnancies with any detected/ suspicious anatomical or genetic fetal anomalies, biochemical abnormalities, increased nuchal translucency measurements, and pregnancies of artificial reproduction techniques were excluded from data analyses. Mean±standard deviation, median and percentile values of the length of nasal bone were calculated separately for 11 [0][1][2][3][4][5][6] , 12 0-6 and 13 0-6 gestational weeksResults: Nasal bone could be visualized in 99.6% of the included 1762 singleton pregnancies. In 16.5% of the cases nasal bones were only noted as present or absent. Mean maternal age was 29.67±4.50 years and mean gestational age was 12.54±0.61 weeks. Median values of nasal bone lengths were 1.7, 1.9, and 2.2 mm for 11 [0][1][2][3][4][5][6] , 12 0-6 and 13 0-6 gestational weeks respectively. Nasal bone length (NBL) increased linearly with advancing gestational age and CRL. NBL (mm) Conclusion:The present study presents normative values of nasal bone in the first trimester screening of normal singleton pregnancies of Turkish population. Nasal bone length increases with advancing gestational age and CRL. (J Turkish-German Gynecol Assoc 2011; 12: 225-8) Key words: Screening, nasal bone, pregnancy, ultrasonography, fetus Received: 11 August, 2011 Accepted: 26 September, 2011 Amaç: Birinci tirmester trizomi 21 taramas nda nazal kemik de erlendirmesi performans artt rmaktad r. Bu retrospektif çal mada Türk popülasyonundaki tekil gebeliklerde birinci trimester fetal nazal kemik ölçümlerinin gebelik haftalar na göre persentil da l mlar n n saptanmas amaçland .

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Normative values of fetal nasal bone lengths of Turkish singleton pregnancies in the first trimester

Yayla¹,

Ergin²,

Göynümer³

2011

J Turkish German Gynecol Assoc

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“…Расширение протокола осмотра с оценкой дополни-тельных ультразвуковых маркеров (оценка НК, кровотока в венозном протоке и на трикуспидальном клапане) улуч-шает чувствительность РПС за счет увеличения частоты обнаружения и уменьшения частоты ложно-положитель-ных результатов. В работах многих авторов установлена взаимосвязь между патологией НК и наличием у плода ХА [1,[7][8][9][10].…”

Section: Abstract: Trisomies 21 18 and 13 Prenatal Diagnosis Valuunclassified

“…Патология НК встретилась у 125 (75%) из 162 плодов, и этот показатель выше, чем опубликованный в литературе [1,[7][8][9][10][12][13][14][15], 50%.…”

Section: трисомия 18 (синдром эдвардса)unclassified

Prenatal markers for common chromosomal syndromes. Estimation of prognostic value

Жученко¹,

Andreeva²,

Голошубов³

et al. 2016

Ross. vestn. akush.-ginekol.

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1 Курс пренатальной диагностики кафедры медицинской генетики российской медицинской академии последипломного образования (ректор -акад. ран, проф. л.К. Мошетова) Минздрава россии, Москва, россия; 2 гБуЗ МО «Московский областной научно-исследовательский институт акушерства и гинекологии» (дир. -акад. ран, проф. В.И. Краснопольский) Минздрава Московской области, Москва, россия Пренатальная диагностика патологических состояний является современным методом диспансеризации плода, позволяет определить медицинский и социальный прогноз для жизнеспособности и здоровья будущего ребенка. Поиск и практиче-ское использование знаний о достоверных пренатальных признаках частых врожденных заболеваний определяют эффек-тивность скрининговых программ. Основной целью настоящего исследования явилась оценка значимости известных и поиск новых ультразвуковых признаков, улучшающих диагностику частых хромосомных анеуплоидий для оптимизации скринингового обследования беременных в сроках беременности 11-14 нед. Материал и методы. Материалом для иссле-дования послужили результаты ультразвукового обследования 266 779 беременных, жительниц Московской области, за период 2011-2015 гг., проведенного в рамках раннего пренатального скрининга в сроки беременности 11-14 нед (строго при показателе копчико-теменного размера плода от 45 до 84 мм). Одновременно проводились биохимический скрининг для выявления патологических пренатальных маркеров и расчет индивидуального риска выявления хромосом-ных анеуплоидий на основе единого программного обеспечения. Результаты. Были выявлены 433 плода с трисомией 21, 166 плодов с трисомией 18, 64 плода с трисомией 13. Впервые в российской популяции установлены медианы известных пренатальных ультразвуковых признаков трех частых хромосомных анеуплоидий (трисомии 21, 18 и 13): толщины ворот-никового пространства, частоты сердечных сокращений и состояния носовой кости. Изучена распространенность ряда врожденных пороков развития и особенностей фенотипа плода. Заключение. В перечень дополнительных пренатальных ультразвуковых маркеров могут входить следующие: патология лимфатической системы и дефекты межжелудочковой перегородки при трисомии 21; врожденный порок сердца, микрогнатия, расщелины лица, патологическое положение кистей плода при трисомии 18; пороки развития центральной нервной системы, врожденные пороки сердца, пороки раз-вития и особенности строения лицевого черепа, полидактилия при трисомии 13. авторы информируют об отсутствии конфликта интересов. The investigation was supported by russian humanitarian Science Foundation Grant no. 15-06-10977/15. The prenatal diagnosis of pathological conditions is an up-to-date method for prophylactic medical examination of the fetus, which can determine a medical and social prognosis for a future child's viability and health. a search for and practical use of knowledge about valid prenatal signs of common congenital diseases determine the effectiveness of screening programs. The main purpose of this study was to search for new ultrasound signs that could improve the diagnosis...

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First trimester ultrasonography in screening and detection of fetal anomalies

Sonek

2007

American J of Med Genetics Pt C

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An obstetrical ultrasound examination provides invaluable information regarding the fetus. Until the mid-1980s, ultrasound in the first trimester was limited to localization of the pregnancy, establishing viability, and accurate dating. With the advent of high-resolution ultrasound and transvaginal scanning, a significant amount of information about the fetus can be gained and provided to the patient at a very early stage in gestation. This article provides an overview of the role of first trimester (11-13 þ 6 weeks' gestation) ultrasound in screening and diagnosis of fetal anomalies. The first trimester is an ideal time for screening for aneuploidy, primarily due to the advantages that nuchal translucency (NT) measurement provides. NT measurement is also useful in establishing the risk of congenital cardiac disorders and a number of genetic and non-genetic syndromes. Significant NT thickening is associated with an increase in perinatal morbidity and mortality. Potential mechanisms resulting in increased NT are discussed. A number of new ultrasound markers for fetal aneuploidy have been investigated over the past several years, some of which appear to improve the screening efficacy of early ultrasonography. The role of these is reviewed. A number of fetal anomalies can now be consistently diagnosed in the first trimester. Their appearance at this early gestational age is discussed as well. It is clear that, data obtained by first trimester ultrasound are useful in counseling expectant parents and in planning the appropriate follow-up.

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Examination of fetal nasal bone and repeatability of measurement in early pregnancy

Abstract: Objective To evaluate the examination and measurement of fetal nasal bone at 10-14 weeks of gestation. Methods

Cited by 37 publications

References 8 publications

Normative values of fetal nasal bone lengths of Turkish singleton pregnancies in the first trimester

Normative values of fetal nasal bone lengths of Turkish singleton pregnancies in the first trimester

Prenatal markers for common chromosomal syndromes. Estimation of prognostic value

First trimester ultrasonography in screening and detection of fetal anomalies

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