2007
DOI: 10.1016/j.jconrel.2007.05.017
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Ex vivo evaluation of bioadhesive films for buccal delivery of fentanyl

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Cited by 85 publications
(36 citation statements)
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“…The development of buccal films has increased dramatically over the past decade as a promising alternative delivery for various therapeutic classes including proteins and peptides [97e99], analgesics [100], antinflammatory [101] and anesthetic drugs [102]. Recently, mucoadhesive films have been prepared and marketed for transmucosal buccal delivery of BCS class II drugs with a special interest into analgesic agents (fentanyl citrate buccal soluble film marketed as Onsolis ® /Breakyl ® , indicated for the treatment of breakthrough pain).…”
Section: Films/patchesmentioning
confidence: 99%
See 1 more Smart Citation
“…The development of buccal films has increased dramatically over the past decade as a promising alternative delivery for various therapeutic classes including proteins and peptides [97e99], analgesics [100], antinflammatory [101] and anesthetic drugs [102]. Recently, mucoadhesive films have been prepared and marketed for transmucosal buccal delivery of BCS class II drugs with a special interest into analgesic agents (fentanyl citrate buccal soluble film marketed as Onsolis ® /Breakyl ® , indicated for the treatment of breakthrough pain).…”
Section: Films/patchesmentioning
confidence: 99%
“…Films cast from aerated solutions exhibit an uneven surface and heterogeneous thickness. The casting method was employed in 2007 by Diaz del Consuelo et al [100] to develop bioadhesive films based on PVP at two different molecular weights, lower molecular weight (PVP K30) and higher molecular weight (PVP K90), for buccal delivery of fentanyl. The Authors highlighted the importance of the rheological properties of cast polymer solution, demonstrating that the low viscosity of PVP K30 would not be compatible with prolonged adhesion in vivo.…”
Section: Films/patchesmentioning
confidence: 99%
“…Esophageal mucosa of a crossbred pig (hybrid types of Duroc Jersey-Landrace-Large White) weighing 80-100 kg was obtained from a local slaughterhouse (Non Muang Village, Khon Kaen, Thailand). The porcine esophageal tube was opened longitudinally and immersed in 0.9% sodium chloride at 60°C for 1 min (19,20). The epithelium was then peeled away from the connective tissue and stored at −20°C.…”
Section: In Vitro Permeation Studiesmentioning
confidence: 99%
“…The esophageal mucosa was obtained from crossbred pigs (hybrid kinds of Duroc JerseyLandrace-Large White) that weighed between 80-100 kg and was purchased from a local slaughterhouse (Non-Muang Village, Khon Kaen, Thailand). The porcine esophageal tube was opened longitudinally and immersed in 0.9% sodium chloride at 60 °C for 1 min [31,32]. The epithelium was then peeled away from the connective tissue.…”
Section: Mucosa Preparationmentioning
confidence: 99%