Ex vivo evaluation of bioadhesive films for buccal delivery of fentanyl

Consuelo, Isabel Diaz del; Falson, Françoise; Guy, Richard H.; Jacques, Yves

doi:10.1016/j.jconrel.2007.05.017

Cited by 85 publications

(36 citation statements)

References 13 publications

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“…The development of buccal films has increased dramatically over the past decade as a promising alternative delivery for various therapeutic classes including proteins and peptides [97e99], analgesics [100], antinflammatory [101] and anesthetic drugs [102]. Recently, mucoadhesive films have been prepared and marketed for transmucosal buccal delivery of BCS class II drugs with a special interest into analgesic agents (fentanyl citrate buccal soluble film marketed as Onsolis ® /Breakyl ® , indicated for the treatment of breakthrough pain).…”

Section: Films/patchesmentioning

confidence: 99%

“…Films cast from aerated solutions exhibit an uneven surface and heterogeneous thickness. The casting method was employed in 2007 by Diaz del Consuelo et al [100] to develop bioadhesive films based on PVP at two different molecular weights, lower molecular weight (PVP K30) and higher molecular weight (PVP K90), for buccal delivery of fentanyl. The Authors highlighted the importance of the rheological properties of cast polymer solution, demonstrating that the low viscosity of PVP K30 would not be compatible with prolonged adhesion in vivo.…”

Section: Films/patchesmentioning

confidence: 99%

See 1 more Smart Citation

A focus on mucoadhesive polymers and their application in buccal dosage forms

Russo

Selmin

Baldassari

et al. 2016

Journal of Drug Delivery Science and Technology

138

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Section: Films/patchesmentioning

confidence: 99%

Section: Films/patchesmentioning

confidence: 99%

A focus on mucoadhesive polymers and their application in buccal dosage forms

Russo

Selmin

Baldassari

et al. 2016

Journal of Drug Delivery Science and Technology

138

View full text Add to dashboard Cite

“…Esophageal mucosa of a crossbred pig (hybrid types of Duroc Jersey-Landrace-Large White) weighing 80-100 kg was obtained from a local slaughterhouse (Non Muang Village, Khon Kaen, Thailand). The porcine esophageal tube was opened longitudinally and immersed in 0.9% sodium chloride at 60°C for 1 min (19,20). The epithelium was then peeled away from the connective tissue and stored at −20°C.…”

Section: In Vitro Permeation Studiesmentioning

confidence: 99%

Influence of pH Modifiers and HPMC Viscosity Grades on Nicotine–Magnesium Aluminum Silicate Complex-Loaded Buccal Matrix Tablets

Kanjanabat

2012

AAPS PharmSciTech

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Abstract. Hydroxypropyl methylcellulose (HPMC) tablets containing nicotine-magnesium aluminum silicate (NCT-MAS) complex particles and pH modifiers, namely, sodium chloride, citric acid, and magnesium hydroxide, were prepared using the direct compression method. The effects of HPMC viscosity grades and pH modifiers on NCT release and permeation of the matrix tablets were examined. The results showed that the higher the viscosity grade of HPMC that was used in the tablets, the lower was the unidirectional NCT release rate found. The unidirectional NCT permeation was not affected by the viscosity grade of HPMC because the NCT diffusion through the mucosal membrane was the rate-limiting step of the permeation. Incorporation of magnesium hydroxide could retard NCT release, whereas the enhancement of unidirectional NCT release was found in the tablets containing citric acid. Citric acid could inhibit NCT permeation due to the formation of protonated NCT in the swollen tablets at an acidic pH. Conversely, the NCT permeation rate increased with the use of magnesium hydroxide as a result of the neutral NCT that formed at a basic microenvironmental pH. The swollen HPMC tablets, with or without pH modifiers, gave sufficient adhesion to the mucosal membrane. Furthermore, the addition of magnesium hydroxide to the matrix tablets was the major factor in controlling buccal delivery of NCT. This study suggests that the NCT-MAS complex-loaded HPMC tablets, which contained magnesium hydroxide, are potential buccal delivery systems of NCT.KEY WORDS: buccal tablet; hydroxypropyl methylcellulose; magnesium aluminum silicate; nicotine; pH modifier.

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“…The esophageal mucosa was obtained from crossbred pigs (hybrid kinds of Duroc JerseyLandrace-Large White) that weighed between 80-100 kg and was purchased from a local slaughterhouse (Non-Muang Village, Khon Kaen, Thailand). The porcine esophageal tube was opened longitudinally and immersed in 0.9% sodium chloride at 60 °C for 1 min [31,32]. The epithelium was then peeled away from the connective tissue.…”

Section: Mucosa Preparationmentioning

confidence: 99%

Preparation and Characterization of Poly (Vinyl Alcohol)–poly (Vinyl Pyrrolidone) Mucoadhesive Buccal Patches for Delivery of Lidocaine HCL

Jaipakdee

Limpongsa

2018

Int J App Pharm

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Objective: The objectives of this study were to prepare and characterize a buccal mucoadhesive patch using poly (vinyl alcohol) (PVA), poly (vinyl pyrrolidone) (PVP) as a mucoadhesive matrix, Eudragit S100 as a backing layer, and lidocaine HCl as a model drug.Methods: Lidocaine HCl buccal patches were prepared using double casting technique. Molecular interactions in the polymer matrices were studied using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC) and X-ray diffractometry. Mechanical and mucoadhesive properties were measured using texture analyzer. In vitro permeation of lidocaine HCl from the patch was conducted using Franz diffusion cell.Results: Both of the free and lidocaine HCl patches were smooth and transparent, with good flexibility and strength. ATR-FTIR, DSC and X-ray diffractometry studies confirmed the interaction of PVA and PVP. Mechanical properties of matrices containing 60% PVP were significantly lower than those containing 20% PVP (*P<0.05). Mucoadhesive properties had a tendency to decrease with the concentration of PVP in the patch. The patch containing 60% PVP had significantly lower muco-adhesiveness than those containing 20% PVP (*P<0.05). In vitro permeation revealed that the pattern of lidocaine HCl permeation started with an initial fast permeation, followed by a slower permeation rate. The initial permeation fluxes follow the zero-order model of which rate was not affected by the PVP concentrations in the PVA/PVP matrix. Conclusion:Mucoadhesive buccal patches fabricated with PVA/PVP were successfully prepared. Incorporation of PVP in PVA/PVP matrix affected the strength of polymeric matrix and mucoadhesive property of patches.

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Ex vivo evaluation of bioadhesive films for buccal delivery of fentanyl

Cited by 85 publications

References 13 publications

A focus on mucoadhesive polymers and their application in buccal dosage forms

A focus on mucoadhesive polymers and their application in buccal dosage forms

Influence of pH Modifiers and HPMC Viscosity Grades on Nicotine–Magnesium Aluminum Silicate Complex-Loaded Buccal Matrix Tablets

Preparation and Characterization of Poly (Vinyl Alcohol)–poly (Vinyl Pyrrolidone) Mucoadhesive Buccal Patches for Delivery of Lidocaine HCL

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