Ewing sarcoma/primitive neuroectodermal tumor of the kidney: a case report. Diagnosed by immunohistochemistry and molecular analysis

Saxena, Rakhee; Sait, Sheila; Mhawech‐Fauceglia, Paulette

doi:10.1016/j.anndiagpath.2005.11.001

Cited by 30 publications

(31 citation statements)

References 6 publications

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“…In the case presented by Saxena and colleagues, the patient had disseminated metastatic disease, and was treated with chemotherapy alone. This patient succumbed to the disease and had little to no response from the chemotherapy [Saxena et al 2006]. Successful use of radiation was documented in patients who had residual disease in the regional lymph nodes [Thyavihally et al 2008].…”

Section: Introductionmentioning

confidence: 95%

“…Comments EWS was first described by Stout in 1918. EWS was recognized by Stout to contain small round blue cells arranging into rosettes [Seemayer et al 1975;Saxena et al 2006;Stout, 1918]. Later, John Ewing further characterized these tumors describing them in the diaphysis of long bones [Stout, 1918].…”

Section: Introductionmentioning

confidence: 99%

“…Approximately, 85-90% of EWS can be defined by a DNA translocation t(11;22)(q24;q12) [Ohgaki et al 2010;Saxena et al 2006]. The resultant gene fusion creates a functional oncogene.…”

Section: Introductionmentioning

confidence: 99%

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Primary Ewing sarcoma of the kidney: a symptomatic presentation and review of the literature

Hakky

Gonzalvo

Lockhart

et al. 2012

Therapeutic Advances in Urology

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Materials and methodsWe performed a PubMed search for primary renal EWS up to June 2012. A total of 104 manuscripts were identified and all reports not pertaining to 'renal Ewing sarcoma' were excluded. Thus, 18 manuscripts were included in this study. Review articles on renal EWS were excluded. All articles in which a case was presented and then a metaanalysis was performed were analyzed, and the case presented was included in our study. We excluded the meta-analysis data to ensure that there were no overlaps of data points. ResultsA 33-year-old man presented acutely to the emergency room with a 3-day history of nausea, emesis, and severe left flank pain concerning for renal colic. His medical history was unremarkable. The physical exam revealed left costovertebral angle tenderness. The patient's urine analysis was unremarkable and his serum white blood cell count was 13,000 ng/dl. The patient did present with a slightly elevated creatinine at 1.4 ng/dl. Computerized tomography (CT) scan showed a 4.4 cm × 4.4 cm × 5.8 cm left lower pole renal mass with moderate hydronephrosis (Figures 1 and 2). Chest CT Primary Ewing sarcoma of the kidney: a symptomatic presentation and review of the literature Tariq S. Hakky, Americo A. Gonzalvo, Jorge L. Lockhart and Alejandro R. Rodriguez Abstract: The objective of this review is to discuss the unique nature of primary renal Ewing sarcoma, including incidence, presentation and management. We also report on a common pattern of presentation, consisting of acute flank pain mimicking a renal stone colic, with or without hydronephrosis, and a renal mass discovered during imaging studies of renal Ewing sarcoma. We present our case of renal Ewing sarcoma along with imaging and pathological analysis. We also performed a retrospective review of all cases of renal Ewing sarcoma using PubMed. A total of 48 cases of renal EWS sarcoma have been reported and analyzed in this review. A mean age of 30.4 years was found along with a 61% male predominance. The mean survival was 26.14 months with a lower median survival in patients with advanced metastatic disease. Primary Ewing sarcoma of the kidney is rare. The diagnosis of primary renal EWS can be difficult and is based on a combination of electron microscopy, immunohistochemistry, chromosomal analysis, fluorescence in situ hybridization (FISH) and light microscopy.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Primary Ewing sarcoma of the kidney: a symptomatic presentation and review of the literature

Hakky

Gonzalvo

Lockhart

et al. 2012

Therapeutic Advances in Urology

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“…Primitive neuroectodermal tumor (PNET) arising from the kidney have also been sporadically reported [6]. Similarly to PNETs primary from other locations, renal lesions display the t(11;22)(q24;q12) with the fusion of EWS1 to FLI1 genes [7].…”

Section: Introductionmentioning

confidence: 99%

Pitfalls in the differential diagnosis of renal tumor in an adolescent

Valera

Brassesco

Cortez

et al. 2009

Pediatric Blood & Cancer

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The differential diagnosis of renal tumors, particularly in adolescents, may be challenging. We describe an 11‐year‐old female with a primary intra‐renal mass. Initial differential diagnoses included primitive neuroectodermal tumor (PNET), desmoplastic small round cell tumor (DSRCT), and Wilms Tumor (WT). Extensive pathologic and molecular analysis on initial and relapsed tumor samples confirmed WT. The EWS‐WT1 and EWS‐FLI1 rearrangements, distinctive of DSRCT and PNET were negative. The differential diagnosis on monophasic blastemal WT may be complex. Primary renal DSRCT and PNET have been rarely described. Nevertheless, molecular confirmation for these rare conditions may be necessary in selected cases. Pediatr Blood Cancer 2010;54:319–321. © 2009 Wiley‐Liss, Inc.

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“…It was first described in 1975 by Seemayer and colleagues [1]. Only very few cases of primary EWS have been reported in the literature till date [2][3][4][5][6][7][8][9]. Sources of renal EWS include neural cells that invaginate into the kidney during development.…”

Section: Introductionmentioning

confidence: 99%

Ewings Sarcoma of the Kidney: A Rare Entity

Choubey

Pipara

Kumar

2017

World J Nephrol Urol

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Primary Ewings sarcoma (EWS) of the kidney is a very rare tumor and very few cases have been reported till date. We present a case of a young girl presenting to us with flank pain. On evaluation, she was found to have a renal mass. She was explored and a nephrectomy was done. Histopathology was reported as EWS. She was then planned for adjuvant chemotherapy. Primary EWS of the kidney is characterized by an aggressive course and poor prognosis. Hence, while dealing with renal masses in young patients, this entity should always be kept in mind.

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Ewing sarcoma/primitive neuroectodermal tumor of the kidney: a case report. Diagnosed by immunohistochemistry and molecular analysis

Cited by 30 publications

References 6 publications

Primary Ewing sarcoma of the kidney: a symptomatic presentation and review of the literature

Primary Ewing sarcoma of the kidney: a symptomatic presentation and review of the literature

Pitfalls in the differential diagnosis of renal tumor in an adolescent

Ewings Sarcoma of the Kidney: A Rare Entity

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