Materials and methodsWe performed a PubMed search for primary renal EWS up to June 2012. A total of 104 manuscripts were identified and all reports not pertaining to 'renal Ewing sarcoma' were excluded. Thus, 18 manuscripts were included in this study. Review articles on renal EWS were excluded. All articles in which a case was presented and then a metaanalysis was performed were analyzed, and the case presented was included in our study. We excluded the meta-analysis data to ensure that there were no overlaps of data points. ResultsA 33-year-old man presented acutely to the emergency room with a 3-day history of nausea, emesis, and severe left flank pain concerning for renal colic. His medical history was unremarkable. The physical exam revealed left costovertebral angle tenderness. The patient's urine analysis was unremarkable and his serum white blood cell count was 13,000 ng/dl. The patient did present with a slightly elevated creatinine at 1.4 ng/dl. Computerized tomography (CT) scan showed a 4.4 cm × 4.4 cm × 5.8 cm left lower pole renal mass with moderate hydronephrosis (Figures 1 and 2). Chest CT Primary Ewing sarcoma of the kidney: a symptomatic presentation and review of the literature Tariq S. Hakky, Americo A. Gonzalvo, Jorge L. Lockhart and Alejandro R. Rodriguez Abstract: The objective of this review is to discuss the unique nature of primary renal Ewing sarcoma, including incidence, presentation and management. We also report on a common pattern of presentation, consisting of acute flank pain mimicking a renal stone colic, with or without hydronephrosis, and a renal mass discovered during imaging studies of renal Ewing sarcoma. We present our case of renal Ewing sarcoma along with imaging and pathological analysis. We also performed a retrospective review of all cases of renal Ewing sarcoma using PubMed. A total of 48 cases of renal EWS sarcoma have been reported and analyzed in this review. A mean age of 30.4 years was found along with a 61% male predominance. The mean survival was 26.14 months with a lower median survival in patients with advanced metastatic disease. Primary Ewing sarcoma of the kidney is rare. The diagnosis of primary renal EWS can be difficult and is based on a combination of electron microscopy, immunohistochemistry, chromosomal analysis, fluorescence in situ hybridization (FISH) and light microscopy.
The aim of this study was to evaluate whether interferon [IFN] can affect intracerebrally grown glioma and how alteration of the blood-brain barrier [BBB] may influence this effect. An intracerebrally implanted glioma G-26 (G-26) mouse brain-tumor model was developed and used in these studies. Histological characterization of this intracerebrally grown tumor revealed its anaplastic character. The astrocytic origin of G-26 was evidenced by glial fibrillary acidic protein staining and electron microscopic visualization of glial filaments. A study of tumor progression and animal survival showed development of a well defined tumor nodule within approximately seven days after the implantation. The median animal survival time was 27 +/- 3.8 days. The integrity of the blood-brain barrier [BBB] within the tumor was evaluated by the intravenous injection of horseradish peroxidase at days 3, 7, 10 and 20 after brain tumor implant and compared to 'sham' controls. The tumor-induced BBB alteration was progressive from day 3 to day 20. Glioma-26 subcutaneously passed in C57BL/6 mice was also continuously cultured in vitro. Its proliferation was inhibited by homologous mouse interferon alpha/beta [MuIFN alpha/beta] but not by human interferon alpha lymphoblastoid or human interferon beta. The in vivo studies of G-26 glioma treatment with MuIFN alpha/beta were performed using single bolus of IFN in osmotically altered animals or slow IFN infusion through osmotic micro-pumps. The slow infusion of IFN had no effect on animal survival. However, a statistically significant increase in animal survival was observed after single bolus IFN treatment following osmotic BBB alteration.
We report a rare case of osteolipoma of the parapharyngeal space. Clinicians should be aware that the clinical and radiological features of patients with head and neck osteolipomas may mimic malignant neoplasms. When given deserved consideration, inappropriate treatment of an otherwise benign lesion may be avoided.
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