Evolution of bone transplantation: molecular, cellular and tissue strategies to engineer human bone

Yaszemski, Michael J.; Payne, Richard; Hayes, Wilson C.; Langer, Robert; Mikos, Antonios G.

doi:10.1016/0142-9612(96)85762-0

Cited by 671 publications

(424 citation statements)

References 52 publications

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“…The rate of polymer degradation can be tuned through copolymerization, and changes made in the hydrophobicity and/or crystallinity of the polymer. 134 Common polymers which have been investigated for bone repair applications include polyesters, polydioxanone, poly (propylene fumarate)(PPF), poly(ethylene glycol) (PEG), poly(orthoesters), polyanhydrides, and polyurethanes. An indepth discussion on polymers including degradation mechanisms and bioactive molecule or drug encapsulation and release for bone tissue engineering applications is provided below.…”

Section: Bone Biomimeticsmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

676

499

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Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of a tissue‐engineered scaffold is to use engineering principles to incite and promote the natural healing process of bone which does not occur in critical‐sized defects. A synthetic bone scaffold must be biocompatible, biodegradable to allow native tissue integration, and mimic the multidimensional hierarchical structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold is capable of eluting bioactive molecules (e.g., BMPs, TGF‐βs, etc., to accelerate extracellular matrix production and tissue integration) or drugs (e.g., antibiotics, cisplatin, etc., to prevent undesired biological response such as sepsis or cancer recurrence) in a temporally and spatially controlled manner. Various biomaterials including ceramics, metals, polymers, and composites have been investigated for their potential as bone scaffold materials. However, due to their tunable physiochemical properties, biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an overview of local drug delivery as it pertains to bone tissue engineering is included. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009

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Section: Bone Biomimeticsmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

676

499

View full text Add to dashboard Cite

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“…A interconectividade é a característica principal da porosidade que tem se confirmado ao longo de vários estudos, como sendo responsável pela manutenção e crescimento do tecido ósseo, pelo transporte de nutrientes e drenagem de líquidos intersticiais [21][22][23]. Poros com dimensões próximas de 5 μm, ainda podem facilitar a migração iônica que ocorre inicialmente entre a superfície do implante e o plasma sangüíneo, influenciando de maneira positiva a dinâmica de adsorção celular, a capilaridade e a permeabilidade dos fluidos corpóreos, que poderiam contribuir na dissolução desta cerâmica [21,23].…”

Section: Hapu-28 77unclassified

“…Poros com dimensões próximas de 5 μm, ainda podem facilitar a migração iônica que ocorre inicialmente entre a superfície do implante e o plasma sangüíneo, influenciando de maneira positiva a dinâmica de adsorção celular, a capilaridade e a permeabilidade dos fluidos corpóreos, que poderiam contribuir na dissolução desta cerâmica [21,23].…”

Section: Hapu-28 77unclassified

Desenvolvimento de biocerâmicas porosas de hidroxiapatita para utilização como scaffolds para regeneração óssea

Fook

Aparecida²,

Fook

2010

Matéria (Rio J.)

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Biocerâmicas porosas tem aplicações biomédicas importantes como preenchimento de defeitos ósseos e scaffolds na engenharia de tecidos. A hidroxiapatita (HA, Ca10(PO4)6(OH)2) que apresenta semelhança química e estrutural com a fase mineral dos ossos e dos dentes, é biocompatível e osteocondutiva, e tem excelente afinidade química e biológica com os tecidos ósseos. Este trabalho teve como objetivo desenvolver biocerâmicas porosas HA para utilização como scaffold para regeneração óssea empregando-se a técnica de réplica da esponja polimérica. A pasta biocerâmica de HA foi obtida por via úmida utilizando hidróxido de cálcio [Ca(OH)2] e ácido fosfórico (H3PO4) e impregnada em esponjas de poliuretano com diferentes densidades. Tratamento térmico a 600°C por 1h foi realizado para eliminação da esponja seguido da sinterização a 1100°C por 2 horas. Os scaffolds apresentaram a HA como fase majoritária, elevada porosidade (> 70%) e poros com tamanhos variando na ordem de macro (>100μm) e microporosidade (1-20μm), sendo estes fatores adequados para a aplicação como scaffolds para regeneração óssea.

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“…With several advantages over either autografts, allografts or xenografts, alloplasts can be very effective bone substitutes [5][6][7][8][9][10][11]. For instance, the transmission of antigens is avoided and the quantity of the biomaterial is relatively abundant [12]. In addition, with particulates, the surface area for more chemical and biological reactions to take place is increased.…”

Section: Introductionmentioning

confidence: 99%

“…If the implant remains strong the newly generated bone is shielded from external forces and osteogenesis is considerably affected [12]. Hing [14] observed that the biomechanical properties of bovine trabecular bone matrix (BBM) blocks of apparent density range, 1.09-1.38 Mg m À3 , exhibited the same mechanical behaviour throughout the implantation period, thus were unaffected by the newly formed bone.…”

Section: Introductionmentioning

confidence: 99%

Cancellous bone repair using bovine trabecular bone matrix particulates

2002

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Cancellous bone repair using bovine trabecular bone matrix particulates. Mushipe, M. (2002). Cancellous bone repair using bovine trabecular bone matrix particulates. Biomaterials, 23(2)(2), 365-370. DOI: 10.1016/S0142-9612(01)00114-4 Published in: BiomaterialsQueen's University Belfast -Research Portal: Link to publication record in Queen's University Belfast Research Portal General rights Copyright for the publications made accessible via the Queen's University Belfast Research Portal is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights.Take down policy The Research Portal is Queen's institutional repository that provides access to Queen's research output. Every effort has been made to ensure that content in the Research Portal does not infringe any person's rights, or applicable UK laws. If you discover content in the Research Portal that you believe breaches copyright or violates any law, please contact openaccess@qub.ac.uk. AbstractAt 5 and 15 weeks post-surgery, biomechanical and histological analyses of cancellous bone defects filled with the bovine trabecular bone matrix (BBM) and hydroxyapatite (Hap) particulates of dimensions 106-150 mm were investigated. It was observed that at 5 weeks post-surgery the stiffness properties of the BBM filled defects were significantly higher than those observed in the Hap filled defects (p50:01) but comparable to those recorded in intact cancellous bone from the same anatomical position. Histologically, no significant differences were observed in the percentage of new bone contact with the particles. The biomechanical properties of the Hap filled defects mirrored those in intact cancellous bone only at 15 weeks post-surgery. BBM particles thus appeared to accelerate the early healing of osteotomies. It is therefore suggested that particles of this bioceramic be the subject of intense research for more usage in both periodontal osseous defects and orthopaedic fractures. #

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Evolution of bone transplantation: molecular, cellular and tissue strategies to engineer human bone

Cited by 671 publications

References 52 publications

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Desenvolvimento de biocerâmicas porosas de hidroxiapatita para utilização como scaffolds para regeneração óssea

Cancellous bone repair using bovine trabecular bone matrix particulates

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