Cancellous bone repair using bovine trabecular bone matrix particulates

Abstract

Cancellous bone repair using bovine trabecular bone matrix particulates. Mushipe, M. (2002). Cancellous bone repair using bovine trabecular bone matrix particulates. Biomaterials, 23(2)(2), 365-370. DOI: 10.1016/S0142-9612(01)00114-4 Published in: BiomaterialsQueen's University Belfast -Research Portal: Link to publication record in Queen's University Belfast Research Portal General rights Copyright for the publications made accessible via the Queen's University Belfast Research Portal is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights.Take down policy The Research Portal is Queen's institutional repository that provides access to Queen's research output. Every effort has been made to ensure that content in the Research Portal does not infringe any person's rights, or applicable UK laws. If you discover content in the Research Portal that you believe breaches copyright or violates any law, please contact openaccess@qub.ac.uk. AbstractAt 5 and 15 weeks post-surgery, biomechanical and histological analyses of cancellous bone defects filled with the bovine trabecular bone matrix (BBM) and hydroxyapatite (Hap) particulates of dimensions 106-150 mm were investigated. It was observed that at 5 weeks post-surgery the stiffness properties of the BBM filled defects were significantly higher than those observed in the Hap filled defects (p50:01) but comparable to those recorded in intact cancellous bone from the same anatomical position. Histologically, no significant differences were observed in the percentage of new bone contact with the particles. The biomechanical properties of the Hap filled defects mirrored those in intact cancellous bone only at 15 weeks post-surgery. BBM particles thus appeared to accelerate the early healing of osteotomies. It is therefore suggested that particles of this bioceramic be the subject of intense research for more usage in both periodontal osseous defects and orthopaedic fractures. #

In Vivo Regenerative Properties of Coralline‐Derived (Biocoral) Scaffold Grafts in Human Maxillary Defects: Demonstrative and Comparative Study with Beta‐Tricalcium Phosphate and Biphasic Calcium Phosphate by Synchrotron Radiation X‐Ray Microtomography

“…This is critical because cells and growth factors are the two key elements when discussing bone biology/healing, their interaction being fundamental for an effective regeneration process. 14 The formation of three-dimensional scaffolds from biomaterials in particulate or block form creates the potential for these systems to be used either in an acellular strategy (implanting of the scaffold and colonization of it by surrounding cells) or combining it with cells in vitro, creating a hybrid cell-material construct. The combination of materials, cells, and growth factors seems to be the recipe for a truly effective bone TE strategy.…”

Critical Size Bone Defect Healing Using Collagen–Calcium Phosphate Bone Graft Materials

“…Collagen–tricalcium phosphate bone graft substitutes were examined in the current study by characterisation from a material science point of view and in vivo using a critical size cancellous defect model [20,38,40–42,57] and at the cell and tissue level using histology and immunohistochemical expression MMP-1, MMP-13 and Cathepsin K [58–60] factors known to be involved in the degradation of the components of bone. While the inorganic tricalcium phosphate and organic collagen matrix of these materials as well as the BMA hydration and surgical handling were virtually identically, bone healing, implant resorption and local tissue reactions however revealed a different result.…”

“…The experimental model of a critical size defect in cancellous bone of the skeletally mature NZ White Rabbit provides a robust experimental means to evaluate the in vivo response of potential bone graft substitutes [20,32,33,40–42,57]. Nevertheless, it remains limited in the pre-clinical nature.…”

The healing response to implants used in joint replacement

“…Bioactive glasses and glass ceramics are also useful in promoting bone formation. Bone is formed in apposition to these materials and de novo in the interstices between HA or bioactive glass particles (Mushipe et al, 2002a(Mushipe et al, , 2002bDamien and Revell, 2005a, b). There is evidence from experiments in rabbit that the amount of bone growth into porous HA is affected by macroporosity, microporosity and chemical composition (Hing et al, 1999(Hing et al, , 2004(Hing et al, , 2005(Hing et al, , 2006Patel et al, 2002;Damien et al, 2003;Revell et al, 2004).…”