Tetracycline (TC), one of the most common antibiotics, is often poorly bio-degraded in conventional wastewater treatment plants. In this study, the sonocatalytic degradation of TC was investigated using TiO 2 nano-particles as catalyst. The effect of pH, initial TC concentrations, reaction times, and H 2 O 2 concentrations were evaluated. The efficacy of ultrasonic irradiation alone in the removal of this pollutant was negligible but removal efficiency increased upon addition of TiO 2 up to 250 mg L À1 ; increase of pH and initial TC concentration attenuated TC degradation. Addition of H 2 O 2 raised the removal efficiency so that complete removal of TC was achieved within 75 min.