Evidence of oxygen limitation in a hollow fibre reactor with immobilized E. coli

A continuous membrane bioreactor (CMB) with Ceraflo ceramic microfilter was evaluated for the production of phenylacetylcarbinol (PAC) using 12-15 g dm-3 Candida utilis. Compared with the classical continuous fermentation, the CMB process was shown to have higher biomass concentration (from 40% to 400% increase) and greater growth rate (from 3-to 9-fold) at dilution rates varying from 0.03 h-' to 0.23 h-'. These advantages were partially offset by the reduced permeate flux caused by the increased biomass. Furthermore, an addition of only 3.0 cm3 h-' benzaldehyde for 17 h (a typical bioconversion protocol) was found to kill the yeast, resulting in 27% dead organisms and 35% lysed organisms and their associated species. This led to a 100% flux decline during the course of PAC production over the above period.

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Applicability of continuous membrane bioreactor in production of phenylacetylcarbinol

Liew

Fane

Rogers

1995

J of Chemical Tech & Biotech

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Membranes and bioreactors

Heath

Belfort

1990

International Journal of Biochemistry

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The uses and future potential of microbial hollow-fibre bioreactors

Bunch

1988

Journal of Microbiological Methods

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Evidence of oxygen limitation in a hollow fibre reactor with immobilized E. coli

Cited by 5 publications

References 2 publications

Applicability of continuous membrane bioreactor in production of phenylacetylcarbinol

Applicability of continuous membrane bioreactor in production of phenylacetylcarbinol

Membranes and bioreactors

The uses and future potential of microbial hollow-fibre bioreactors

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