Membranes and bioreactors

Heath, Carole A.; Belfort, Georges

doi:10.1016/0020-711x(90)90285-b

Cited by 24 publications

(7 citation statements)

References 51 publications

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“…As the oxygen-poor blood flows across the hollow fiber bundle, it generates transverse mixing that is essential for enhanced gas exchange between oxygen inside the fiber and the carbon dioxide from the blood flowing over the bundle. Hollow fiber modules are widely used in bioprocesses (Heath and Belfort, 1990; Ghosh et al, 2000) and in biomedical fields (Fukuda et al, 1998; Kolobow et al, 1986; Haworth, 2003) because of their high mass transfer performance. One of the most essential hollow fiber modules is a membrane oxygenator.…”

Section: Introductionmentioning

confidence: 99%

The Role of Porous Media in Modeling Fluid Flow Within Hollow Fiber Membranes of the Total Artificial Lung

2012

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A numerical study was conducted to analyze fluid flow within hollow fiber membranes of the artificial lungs. The hollow fiber bundle was approximated using a porous media model. In addition, the transport equations were solved using the finite-element formulation based on the Galerkin method of weighted residuals. Comparisons with previously published work on the basis of special cases were performed and found to be in excellent agreement. A Newtonian viscous fluid model for the blood was used. Different flow models for porous media, such as the Brinkman-extended Darcy model, Darcy’s law model, and the generalized flow model, were considered. Results were obtained in terms of streamlines, velocity vectors, and pressure distribution for various Reynolds numbers and Darcy numbers. The results from this investigation showed that the pressure drop across the artificial lung device increased with an increase in the Reynolds number. In addition, the pressure drop was found to increase significantly for small Darcy numbers.

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Section: Introductionmentioning

confidence: 99%

The Role of Porous Media in Modeling Fluid Flow Within Hollow Fiber Membranes of the Total Artificial Lung

2012

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“…Since they operate at moderate reaction conditions without any additives, they offer a convenient method for ISPR without affecting the producing organism [3,4].…”

Section: Introductionmentioning

confidence: 99%

Reverse-flow diafiltration for continuous in situ product recovery

Carstensen

Marx

André

et al. 2012

Journal of Membrane Science

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“…Most membrane bioreactors retain enzymes by sieving or by surface immobilization while allowing substrates and products through 15–17. This approach is not particularly suitable for processing macromolecular substrates.…”

Section: Introductionmentioning

confidence: 99%

Enzymatic fragmentation of cation exchange membrane bound immunoglobulin G

Ghosh

2010

Biotechnology Progress

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Immunoglobulin G (IgG) was immobilized on a stack of microporous cation-exchange membranes and pulsed with pepsin solution. Fc fragment and its sub-fragments thus produced were removed along with the reaction flow-through, whereas F(ab')(2) which remained membrane bound could subsequently be eluted in a pure form using salt. The extent of IgG fragmentation and the apparent reaction rate constant were both significantly higher than in equivalent liquid phase reaction, presumably due to a combination of mass transport, steric, and substrate concentration effects. This approach of using a membrane surface as molecule cutting board could be attractive in niche applications such as integrated enzymatic reaction and purification processes involving macromolecular substrates.

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Membranes and bioreactors

Cited by 24 publications

References 51 publications

The Role of Porous Media in Modeling Fluid Flow Within Hollow Fiber Membranes of the Total Artificial Lung

The Role of Porous Media in Modeling Fluid Flow Within Hollow Fiber Membranes of the Total Artificial Lung

Reverse-flow diafiltration for continuous in situ product recovery

Enzymatic fragmentation of cation exchange membrane bound immunoglobulin G

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