Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation

Maldonado, Mónica; Mora-Santos, Mar; Naji, Latifa; Carrascosa-Salmoral, M. P.; Naranjo, María C.; Calvo, Juan R.

doi:10.1016/j.phrs.2009.11.014

Cited by 97 publications

(97 citation statements)

References 31 publications

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“…Mast cells are important resident leukocytes in the gingiva [22]. A study has shown synthesis and release of melatonin from human mast cells [23]. This phenomenon could operate in the gingiva also.…”

Section: Discussionmentioning

confidence: 99%

Gingival, Plasma and Salivary Levels of Melatonin in Periodontally Healthy Individuals and Chronic Periodontitis Patients: A Pilot Study

Balaji

Vasanthi

Rao

2015

JCDR

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Section: Discussionmentioning

confidence: 99%

Gingival, Plasma and Salivary Levels of Melatonin in Periodontally Healthy Individuals and Chronic Periodontitis Patients: A Pilot Study

Balaji

Vasanthi

Rao

2015

JCDR

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“…Less widely recognized is melatonin's production in parts of the body other than the pineal gland, such as in the digestive system and in immune cells including mast cells [7] . The total amount of melatonin in the digestive tract exceeds that of the pineal gland and blood.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of melatonin on pediatric functional dyspepsia: A pilot study

Zybach

Friesen

Schurman

2016

WJGPT

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AIM:To study the effectiveness of melatonin vs placebo in children with functional dyspepsia (FD). METHODS:The study was conducted as a double blind, randomized, placebo controlled crossover trial. Subjects were aged 8-17 years and diagnosed with FD based on Rome Ⅲ criteria. All subjects had failed to respond to 4 wk of acid suppression. Subjects receive a continuous two weeks of placebo and a continuous two weeks of melatonin in an order blinded to the participant and the study team. A Global Clinical Score was obtained to assess changes in abdominal pain. Pain was self-reported to be worse (grade 1), no change (grade 2), moderate improvement (grade 3), good (grade 4; minimal pain and not interfering with daily activities), or excellent (grade 5; no pain), respectively. A positive clinical response was defined as a grade 3 or greater response. Subjects wore an actigraph to assess sleep during a one week baseline period and during each treatment period. Subjects' sleep latency and total sleep time were recorded throughout the duration of the study. RESULTS:Fourteen subjects were enrolled and 12 completed the study. One withdrew prior to starting both melatonin and placebo and the other before starting melatonin. A positive clinical response (grade 3-5) was achieved in 42% of subjects on melatonin vs 50% of subjects on placebo (NS). Effect size was calculated

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“…Melatonin receptors are detectable in T helper cells, lymphocytes, granulocytes, mast cells and monocytes/macrophages [64][65][66][67][68]. On the other hand, bone marrow cells and the mast cell line RBL-2H3 are able to synthesize melatonin [68,69].…”

Section: Melatonin In Testicular Immune Cellsmentioning

confidence: 99%

Local Actions of Melatonin in Somatic Cells of the Testis

Frungieri¹,

Calandra²,

Rossi³

2017

Preprint

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Environmental darkness signal is transferred from the retina to the pineal gland triggering melatonin secretion. Melatonin influences the synthesis and release of the hypothalamic GnRH and the adenohypophyseal gonadotropin hormones and therefore, regulates testicular function in photoperiodic species.Besides the brain, direct actions of melatonin at the testicular level have also been Peer-reviewed version available at Int. J. Mol. Sci. 2017, 18, , 1170 doi:10.3390/ijms18061170 2 of 41 protective effects against oxidative stress in testicular mast cells. These data pinpoints melatonin as a key player in the regulation of testicular physiology (i.e. steroidogenesis, spermatogenesis) mostly in seasonal breeders. More importantly, melatonin is also involved in the modulation of testicular inflammatory and oxidant/anti-oxidant states in patients with idiopathic infertility.

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Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation

Cited by 97 publications

References 31 publications

Gingival, Plasma and Salivary Levels of Melatonin in Periodontally Healthy Individuals and Chronic Periodontitis Patients: A Pilot Study

Gingival, Plasma and Salivary Levels of Melatonin in Periodontally Healthy Individuals and Chronic Periodontitis Patients: A Pilot Study

Therapeutic effect of melatonin on pediatric functional dyspepsia: A pilot study

Local Actions of Melatonin in Somatic Cells of the Testis

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