Therapeutic effect of melatonin on pediatric functional dyspepsia: A pilot study

Zybach, Katherine; Friesen, Craig A.; Schurman, Jennifer Verrill

doi:10.4292/wjgpt.v7.i1.156

Cited by 23 publications

(12 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…208,209 To our knowledge, there have been 15 randomized placebocontrolled trials of medications for pediatric FAPDs. 158,[210][211][212][213][214][215][216][217][218][219][220][221][222][223] We have summarized these studies in Table 3. The current data does not lend itself to the development of pediatric practice guidelines regarding medication treatment for pediatric FAPDs as have been developed for adult IBS.…”

Section: Medicationsmentioning

confidence: 99%

An Update on the Assessment and Management of Pediatric Abdominal Pain

Friesen¹,

Colombo²,

Deacy³

et al. 2021

PHMT

View full text Add to dashboard Cite

Chronic abdominal pain is very common in children and adolescent and results in high personal and social costs. Most youth with chronic abdominal pain fulfill criteria for a functional abdominal pain disorder (FAPD) as defined by Rome criteria. These are complex conditions with a wide array of biological, psychological, and social factors contributing to the experience of pain. The purpose of the current review is to provide an overview of the pathophysiology of FAPDs and an up-to-date summary of the literature related to FAPDs in children and adolescents, with additional focus on several areas (eg, diet and probiotics) where patients and families frequently have questions or implement self-directed care. We also provide an approach to the assessment and treatment of pediatric FAPDs focusing on the robust literature regarding psychological interventions and much sparser literature regarding medication treatment.

show abstract

Section: Medicationsmentioning

confidence: 99%

An Update on the Assessment and Management of Pediatric Abdominal Pain

Friesen¹,

Colombo²,

Deacy³

et al. 2021

PHMT

View full text Add to dashboard Cite

show abstract

“…Melatonin has been investigated as a therapeutic agent for FD and IBS, however, the efficacy remains unclear. A study on paediatric FD found that melatonin had no significant effect ( Zybach, 2016 ), however, another study found that FD participants showed significant improvement in sleep quality and abdominal pain ( Klupinska et al, 2007 ). Similarly, disturbances in melatonin metabolism and secretion have been suggested to play a role in the pathophysiology of IBS ( Radwan et al, 2009 ).…”

Section: Disorders Of Gut-brain Interactionsmentioning

confidence: 99%

Circadian Rhythms and Melatonin Metabolism in Patients With Disorders of Gut-Brain Interactions

et al. 2022

View full text Add to dashboard Cite

Circadian rhythms are cyclic patterns of physiological, behavioural and molecular events that occur over a 24-h period. They are controlled by the suprachiasmatic nucleus (SCN), the brain’s master pacemaker which governs peripheral clocks and melatonin release. While circadian systems are endogenous, there are external factors that synchronise the SCN to the ambient environment including light/dark cycles, fasting/fed state, temperature and physical activity. Circadian rhythms also provide internal temporal organisation which ensures that any internal changes that take place are centrally coordinated. Melatonin synchronises peripheral clocks to the external time and circadian rhythms are regulated by gene expression to control physiological function. Synchronisation of the circadian system with the external environment is vital for the health and survival of an organism and as circadian rhythms play a pivotal role in regulating GI physiology, disruption may lead to gastrointestinal (GI) dysfunction. Disorders of gut-brain interactions (DGBIs), also known as functional gastrointestinal disorders (FGIDs), are a group of diseases where patients experience reoccurring gastrointestinal symptoms which cannot be explained by obvious structural abnormalities and include functional dyspepsia (FD) and irritable bowel syndrome (IBS). Food timing impacts on the production of melatonin and given the correlation between food intake and symptom onset reported by patients with DGBIs, chronodisruption may be a feature of these conditions. Recent advances in immunology implicate circadian rhythms in the regulation of immune responses, and DGBI patients report fatigue and disordered sleep, suggesting circadian disruption. Further, melatonin treatment has been demonstrated to improve symptom burden in IBS patients, however, the mechanisms underlying this efficacy are unclear. Given the influence of circadian rhythms on gastrointestinal physiology and the immune system, modulation of these rhythms may be a potential therapeutic option for reducing symptom burden in these patients.

show abstract

“…Various treatment options are discussed further in the list below. However, in a randomized controlled trial to evaluate therapeutic effects of melatonin, it was not found to be superior to placebo in children [45]. o Cognitive behavioral therapy (CBT): The impact of an FGID on a patient's life can be directly correlated with the management of psychosocial factors.…”

Section: Treatment Optionsmentioning

confidence: 99%

A comprehensive review of functional dyspepsia in pediatrics

Waseem

Rubin

2021

Clin J Gastroenterol

View full text Add to dashboard Cite

Functional gastrointestinal disorders have been known as a diagnosis of exclusion since the Rome Foundation first created these criteria in 1990. Since that time, a large amount of research and clinical data has better clarified the mechanisms and treatment options for these. Functional dyspepsia is caused by physiologic, genetic, environmental, and psychological factors, as well as various functional abnormalities, such as increased sensitivity to acid, increased sensitivity to duodenal lipids and low-grade inflammation. This disorder has significant symptom overlap between other functional disorders, such as irritable bowel syndrome and gastroparesis, but has differential criteria and two new subclasses: postprandial distress syndrome and epigastric pain syndrome. Diagnosis of functional dyspepsia should be based upon appropriate clinical evaluation in tandem with Rome IV criteria. In recent years, many treatment measures for functional dyspepsia have been studied, such as pharmacologic intervention, behavioral therapy, or alternative therapy, an example being hypnotherapy. These treatment measures have proven to be effective in symptom reduction in pediatrics. Though this disorder is functional, it has been shown to cause a significant impact on pediatric patients' quality of life continuing into adulthood.

show abstract

Therapeutic effect of melatonin on pediatric functional dyspepsia: A pilot study

Cited by 23 publications

References 16 publications

An Update on the Assessment and Management of Pediatric Abdominal Pain

An Update on the Assessment and Management of Pediatric Abdominal Pain

Circadian Rhythms and Melatonin Metabolism in Patients With Disorders of Gut-Brain Interactions

A comprehensive review of functional dyspepsia in pediatrics

Contact Info

Product

Resources

About