Evidence for the Role of the Cecal Microbiome in Maintenance of Immune Regulation and Homeostasis

Chhabra, Preeti; Spano, Anthony; Bowers, Daniel T.; Ren, Tiantian; Moore, Daniel J.; Timko, Michael P.; Wu, Martin; Brayman, Kenneth L.

doi:10.1097/sla.0000000000002930

Cited by 11 publications

(7 citation statements)

References 45 publications

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“…34 In this study, Lactobacillus and Lachnospira were abundant in the cecum, and they played an important role in maintaining immune homeostasis. 35 Lachnospira, which is an SCFA producer, may be a potential beneficial bacterium that participates in the metabolism of a variety of carbohydrates. It also provides energy for the host to ferment to produce lactic acid.…”

Section: Discussionmentioning

confidence: 99%

Spatial distribution of gut microbiota in mice during the occurrence and remission of hyperuricemia

Han

Wang

et al. 2023

J Sci Food Agric

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Background Previous studies have shown that anserine can alleviate hyperuricemia by changing the fecal microbiota of hyperuricemic mice. Topic However, the fecal microbiota could not fully represent the distribution of the whole gut microbiota. Knowing the spatial distribution of the gastrointestinal tract microbiota is therefore important for understanding its action in the occurrence and remission of hyperuricemia. Methods This study provides a comprehensive map of the most common bacterial communities that colonize different parts of the mouse gastrointestinal tract (stomach, duodenum, ileum, cecum, and colon) using a modern methodological approach. Results The stomach, colon, and cecum showed the greatest richness and diversity in bacterial species. Three clusters of bacterial populations were observed along the digestive system: (1) in the stomach, (2) in the duodenum and ileum, and (3) in the colon and cecum. A high purine solution changed the composition and abundance of the digestive tract microbiota, and anserine relieved hyperuricemia by restoring the homeostasis of the digestive tract microbiota, especially improving the abundance of probiotics in the digestive tract. Implication This could be the starting point for further research on the regulation of hyperuricemia by gut microbiota with the ultimate goal of promoting health and welfare. © 2022 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 99%

Spatial distribution of gut microbiota in mice during the occurrence and remission of hyperuricemia

Han

Wang

et al. 2023

J Sci Food Agric

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“…Notably, transplantation of the cecal microbiota from IgM-treated mice showed similar therapeutic effects, suggesting that IgM treatment may exert therapeutic effects by altering the microbiota. 135 Thus, immunotherapy may change the composition of the intestinal microbiota, and it is necessary to consider whether intestinal microbiota is the cause of the observed low success rate of immunotherapy clinical trials.…”

Section: Immunotherapymentioning

confidence: 99%

The Impact of Intestinal Microorganisms and Their Metabolites on Type 1 Diabetes Mellitus

Zheng¹,

Luo²,

Xiao³

2022

DMSO

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Background: Type 1 diabetes mellitus (T1DM) is an autoimmune disease with a complex etiology comprising numerous genetic and environmental factors; however, many of the mechanisms underlying disease development remain unclear. Nevertheless, a critical role has recently been assigned to intestinal microorganisms in T1DM disease pathogenesis. In particular, a decrease in intestinal microbial diversity, increase in intestinal permeability, and the translocation of intestinal bacteria to the pancreas have been reported in patients and animal models with T1DM. Moreover, intestinal microbial metabolites differ between healthy individuals and patients with T1DM. Specifically, short-chain fatty acid (SCFA) production, which contributes to intestinal barrier integrity and immune response regulation, is significantly reduced in patients with T1DM. Considering this correlation between intestinal microorganisms and T1DM, many studies have investigated the potential of intestinal microbiota in preventive and therapeutic strategies for T1DM. Objective: The aim of this review is to provide further support for the notion that intestinal microbiota contributes to the regulation of T1DM occurrence and development. In particular, this article reviews the involvement of the intestinal microbiota and the associated metabolites in T1DM pathogenesis, as well as recent studies on the involvement of the intestinal microbiota in T1DM prevention and treatment. Conclusion:Intestinal microbes and their metabolites contribute to T1DM occurrence and development and may become a potential target for novel therapeutics.

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“…The number of Tregs and MDSC in mice treated with IgM was significantly increased. Oral feeding exhibited a certain effect on this process ( Chhabra et al, 2018 ). This also should be used as another convenient and feasible way to increase the number of MDSC.…”

Section: Mdsc Is a Candidate Target For The Treatment Of Diabetesmentioning

confidence: 99%

Emerging Roles of Myeloid-Derived Suppressor Cells in Diabetes

et al. 2021

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Diabetes is a syndrome characterized by hyperglycemia with or without insulin resistance. Its etiology is attributed to the combined action of genes, environment and immune cells. Myeloid-derived suppressor cell (MDSC) is a heterogeneous population of immature cells with immunosuppressive ability. In recent years, different studies have debated the quantity, activity changes and roles of MDSC in the diabetic microenvironment. However, the emerging roles of MDSC have not been fully documented with regard to their interactions with diabetes. Here, the manifestations of MDSC and their subsets are reviewed with regard to the incidence of diabetes and diabetic complications. The possible drugs targeting MDSC are discussed with regard to their potential of treating diabetes. We believe that understanding MDSC will offer opportunities to explain pathological characteristics of different diabetes. MDSC also will be used for personalized immunotherapy of diabetes.

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Evidence for the Role of the Cecal Microbiome in Maintenance of Immune Regulation and Homeostasis

Abstract: The cecal microbiome appears to be important in maintaining immune homeostasis and normal immune responses.

Cited by 11 publications

References 45 publications

Spatial distribution of gut microbiota in mice during the occurrence and remission of hyperuricemia

Spatial distribution of gut microbiota in mice during the occurrence and remission of hyperuricemia

The Impact of Intestinal Microorganisms and Their Metabolites on Type 1 Diabetes Mellitus

Emerging Roles of Myeloid-Derived Suppressor Cells in Diabetes

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