Emerging Roles of Myeloid-Derived Suppressor Cells in Diabetes

Abstract

Diabetes is a syndrome characterized by hyperglycemia with or without insulin resistance. Its etiology is attributed to the combined action of genes, environment and immune cells. Myeloid-derived suppressor cell (MDSC) is a heterogeneous population of immature cells with immunosuppressive ability. In recent years, different studies have debated the quantity, activity changes and roles of MDSC in the diabetic microenvironment. However, the emerging roles of MDSC have not been fully documented with regard to their interactions with diabetes. Here, the manifestations of MDSC and their subsets are reviewed with regard to the incidence of diabetes and diabetic complications. The possible drugs targeting MDSC are discussed with regard to their potential of treating diabetes. We believe that understanding MDSC will offer opportunities to explain pathological characteristics of different diabetes. MDSC also will be used for personalized immunotherapy of diabetes.

Umbilical cord mesenchymal stromal cells transplantation delays the onset of hyperglycemia in the RIP-B7.1 mouse model of experimental autoimmune diabetes through multiple immunosuppressive and anti-inflammatory responses

“…Of special interest, we also found that hyperglycemic IMM-RIP-B7.1 mice also displayed increased pancreatic infiltration of [CD11b + MHC-II - Gr1 + ] MDSC, which is very striking due to their opposite role with M1 pro-inflammatory macrophages and also since a previous study reported decreased MDSC in islets of NOD mice ( Fu et al 2012 ). Our results are however supported by other studies showing increased MDSC in the peripheral blood and secondary lymphoid organs of NOD and STZ mice models as well as in T1DM and T2DM patients (for review see ( Wang et al 2021 ). A higher number of MDSC during insulitis development is likely a compensatory mechanism to suppress diabetogenic T Cell proliferation.…”

Hydroxychloroquine induces apoptosis of myeloid-derived suppressor cells via up-regulation of CD81 contributing to alleviate lupus symptoms

“…Unlike the deleterious role of MDSCs in tumor, it would be an enormous challenge to confirm a unifying hypothesis showing the functions of MDSCs in various autoimmune diseases. MDSCs were involved in the disease course of SLE, also accompanied with the arguable function (Wang et al 2021 ; Zhang et al 2014 ). Iwata et al have identified the accumulation of MDSCs in the MRL-Fas lpr mice for the first time (Iwata et al 2010 ).…”

Leverage biomaterials to modulate immunity for type 1 diabetes

“…A population cell of myeloid origin with immunoregulatory activity named myeloid-derived suppressor cells (MDSC) is of interest, allowing for great potency in the fields of transplantation and autoimmune diseases ( 112 ). In T1D, MDSC exhibited immunosuppressive ability to some extent, its characteristic and mechanism had been discussed in the pre-existing review ( 113 ). Here, we focus on the studies related to MDSC adoptive therapy.…”