Evidence for the involvement of central serotonin in mechanism of domestication of silver foxes

Попова, Н. К.; Voitenko, N. N.; Куликов, А. В.; Августинович, Д. Ф.

doi:10.1016/0091-3057(91)90080-l

Cited by 116 publications

(62 citation statements)

References 9 publications

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“…In wild Norway rats selected over 20 generations for reduced aggression towards man, mean hypothalamic levels of 5-HIAA and hypothalamic, midbrain and cortical levels of 5-HT were higher than iǹ aggressive' animals (19). Similarly, in domesticated silver foxes selected for tame behaviour over greater than 30 years, serotonin levels in midbrain and hypothalamus and 5-HIAA levels in midbrain, hypothalamus and hippocampus were higher than in foxes not selected for tameness (20). Density of 5-HT1A receptors in hypothalamic membranes was reduced in the domesticated foxes.…”

Section: Animal Studiesmentioning

confidence: 87%

Selective serotonin reuptake inhibitors and violence: a review of the available evidence

Walsh

Dinan²

2001

Acta Psychiatr Scand

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Section: Animal Studiesmentioning

confidence: 87%

Selective serotonin reuptake inhibitors and violence: a review of the available evidence

Walsh

Dinan²

2001

Acta Psychiatr Scand

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“…However, no defensive responses or changes in plasma cortisol level were observed in domesticated foxes (Plyusnina et al 1991). Popova et al (1991) demonstrated that the increased serotonin secretion in foxes is associated with the domestication mechanism of wild aggressive / defensive animals into tame ones.…”

Section: Introductionmentioning

confidence: 99%

“…Fear of humans may induce stress in animals. Stress is partly resulting from hormonal differences (Belyaev 1979, Plyusnina et al 1991, Popova et al 1991, Osadschuk 1992, Bakken et al 1994, Plyusnina et al 1996. Hormo-Vol.…”

Section: Introductionmentioning

confidence: 99%

“…Hormonal changes have been observed simultaneously with genetic changes in behaviour. In foxes selected for confidence (CB) or tameness, a decrease in stress hormones (Plyusnina et al 1991, Osadschuk 1992, Plyusnina et al 1996, Rekilä 1999 and an increase in tryptophan (precursor of serotonin) (Plyusnina et al, 1991, Popova et al, 1991 have been established. In animals selected for enhanced aggressiveness towards human, increase in defensive responses (fear and aggression) was associated with a significant rise in plasma cortisol level.…”

Section: Introductionmentioning

confidence: 99%

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Phenotypic and genetic parameters and responses in temperament of silver fox cubs in a selection experiment for confident behaviour

Kenttämies¹,

Nikkilä²,

Miettinen³

2008

AFSci

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A selection experiment for more confident silver foxes was arranged to find out possibilities to obtain selection response in confidence. Variation in aggressiveness and ease of capture was also studied. Fixed factors affecting the traits were studied using WSYS program. Covariances for breeding values were estimated with REML and multitrait animal models using VCE4 and Pest programs. It appeared that males were more confident than females. Cubs born in small litters tended to be more confident, less aggressive and easier to capture compared to those born in greater litters. Cubs of one-year-old dams seemed to be more confident and easier compared to those of older dams. Moderate estimate of heritability was obtained for confidence (h 2 = 0.22). During three years of selection, genetic response of 0.13 points was achieved in confidence in selection line compared to control line. A higher selection differential existed in males than females. Predicted response of 0.21 points was slightly higher than the estimated one. No heritability was observed in aggressiveness, while a low one existed in ease of capture (h 2 = 0.07). No association between confidence and the other behaviour traits were found.

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“…It has earlier been shown that there are differences in serotonin level between the tame and aggressive founder lines in different brain regions (Naumenko et al 1989;Albert et al 2008). Further, serotonin and its metabolite were higher in several brain regions in a line of foxes selected for tameness than in foxes not selected for behavior (Popova et al 1976(Popova et al , 1991. The 5-HT3 receptor density is also greater in hamsters showing impulsive aggression (Cervantes and Delville 2009) and Htr3a knockout mice exhibit changes in anxiety-like behavior and hypothalamus-pituitary-adrenal (HPA) axis response to stress (Bhatnagar et al 2004).…”

Section: Discussionmentioning

confidence: 98%

Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and Aggression

Heyne

Lautenschlaeger²,

Nelson

et al. 2014

Preprint

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Interindividual differences in many behaviors are partly due to genetic differences, but the identification of the genes and variants that influence behavior remains challenging. Here, we studied an F 2 intercross of two outbred lines of rats selected for tame and aggressive behavior toward humans for .64 generations. By using a mapping approach that is able to identify genetic loci segregating within the lines, we identified four times more loci influencing tameness and aggression than by an approach that assumes fixation of causative alleles, suggesting that many causative loci were not driven to fixation by the selection. We used RNA sequencing in 150 F 2 animals to identify hundreds of loci that influence brain gene expression. Several of these loci colocalize with tameness loci and may reflect the same genetic variants. Through analyses of correlations between allele effects on behavior and gene expression, differential expression between the tame and aggressive rat selection lines, and correlations between gene expression and tameness in F 2 animals, we identify the genes Gltscr2, Lgi4, Zfp40, and Slc17a7 as candidate contributors to the strikingly different behavior of the tame and aggressive animals. B EHAVIORAL differences among members of a species are in part due to genetic variation. The identification of the genes and variants that influence behavior remains challenging. In human genome-wide association studies of psychiatric and cognitive traits, the identified loci typically explain only a small fraction of the heritability, i.e., the additive genetic contribution to the trait (Watanabe et al. 2007;Hovatta and Barlow 2008;Deary et al. 2009;Otowa et al. 2009;Calboli et al. 2010;Terracciano et al. 2010;Flint and Munafo 2013;Rietveld et al. 2013;Sokolowska and Hovatta 2013). In experimental crosses in model species, especially between inbred lines, the identified loci (termed quantitative trait loci, QTL), often explain much more of the heritability (Lynch and Walsh 1998). However, in this design the spatial resolution is limited-the QTL are wide and contain many, sometimes hundreds of genes. With the exception of a handful of identified genes with quantitative effects on behavioral traits (Yalcin et al. 2004;Watanabe et al. 2007;McGrath et al. 2009;Bendesky et al. 2012;Goodson et al. 2012), gene identification is particularly difficult for behavioral QTL that often have modest effect sizes (Flint 2003;Willis-Owen and Flint 2006;Wright et al. 2006;Hovatta and Barlow 2008).The causal variants within a QTL can alter the protein sequence encoded by a gene or affect gene expression. Such Musunuru et al. 2010). A few eQTL studies have also recently been carried out to identify candidate genes for behavioral QTL (Hitzemann et al. 2004;De Jong et al. 2011;Saba et al. 2011;Kelly et al. 2012).Here, we studied two lines of rats (Rattus norvegicus) that, starting from one wild population, have been selected for increased tameness and increased aggression toward humans, respectively. These experimental...

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Evidence for the involvement of central serotonin in mechanism of domestication of silver foxes

Cited by 116 publications

References 9 publications

Selective serotonin reuptake inhibitors and violence: a review of the available evidence

Selective serotonin reuptake inhibitors and violence: a review of the available evidence

Phenotypic and genetic parameters and responses in temperament of silver fox cubs in a selection experiment for confident behaviour

Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and Aggression

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