Evidence for the existence of a gastropancreatic reflex

White, Thomas Taylor; Lundh, G; Magee, D. F.

doi:10.1152/ajplegacy.1960.198.4.725

Cited by 79 publications

(17 citation statements)

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“…In the experiments without any rise of blood sugar this 2nd peak appears most clearly after sham-feeding of glucose to animals with stomach fistulas. This agrees with the release of enterohormones by a directly local stimulation of the stomach mueosa (Grossman, 1962, Grossman et al, 1948, White et al, 1960. With reference to the time pattern, we may compare these findings with the changes of gastldn in the peripheral serum by oral glucose (1VicGuigan and Trudeau, 1970) or a meal (Walsh et al, 1971).…”

Section: Discussionsupporting

confidence: 76%

The Mechanism of Insulin Secretion after Oral Glucose Administration

et al. 1972

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Summary.After sham-feeding of glucose, conscious trained dogs bearing double-barrelled fistulas of the oeso-.phagus or of the stomach do not show any blood sugar mcrease. Nevertheless their Ii%I-lcvels in the peripheral venous blood increased considerably. This increase consists of two peaks of short duration between the 5th and the lOth as well as the 15th and the 25th min. Such IRI-peaks occured also after sham-feeding of tap water, but to a smaller extent. Their temporal order corresponds to the early IRI-peaks after oral glucose administration in intact animals, but before the blood glucose increase which was observed by us previously. After the application of glucose into the oral opening of the oesophageul fistula the first IRI-peak does not occur, the second and the third peaks appeared to the same extent. A feed-forward of insulin secretion induced by oral ingestion is suggested. It may be interpreted within the scope of the "entero-insular axis" of the mechanism of insulin secretion. Le mdeanisme de l'insulino-s~crdtion apr~s administration orale do glucose. IT. Libgration rdflexe do l'insuline chez le chien ~veillg portant des fistules du tractus digestif par alimentation simul~e de glucose ou d'eauRdsum& Des chiens dveillds et entralnds portant des fistules de l'oesophage ou de l'estomuc ne prdsentent aucune 61gvation du sucre sanguin apr@s ulimentation simul6e de glucose, ndanmoins nne augmentation consid@rable de la concentration insulinique duns le sang veineux pdriphdrique appuralt. Celle-ci consiste en deux pics brefs entre la 5 e et la 10 e minet aussi entre la 15 e et la 25e rain. Cos deux pics upparaissent aussi apr~s alimentation simulde d'eau potable, mais ~ un moindre degrd. Leur ordre chronologique correspond aux pics prdcoces d'IRI que nous uvons observds antgrieurement, apr6s administration orale de glucose chez des animaux intacts, avant l'616vation glyc6miquo rdelle. Apr6s application de glucose duns l'ouverture ahorale de la fistule chez des unimuux portant une fistule de l'oesophage, il manque le premier pic d'IRI, le deuxi~me et le troisi@me pic (provoquds par rdsorption) apparaissent invariablement. Line insulino-sdcrdtion intensifi~e, couplde ~ la prise de nourriture et induite par l'ingestion orale est suggdr@e et discutde duns le cadre de l'(~entero-insular axis~) du mgcanisme de l'insulino-s~cr6tion. Der Mechanismus der Insulinselcretion nach oraler Glucosegabe If. .Reflelctorische Insulinfreisetzung beim wachen Hund mit Fistetn dos Magen-Darm-Traktes durch Scheinfi~tterung mit Glucose odor Wasser.Zusammenfassung. Wache trainierte Hunde mit doppell/iuflgen Fistein des Oesophagus odor des Magens zeigen nach Scheinfiitterung mit Glucose keinen Bintzuckeranstieg, aber eine sichere Erh6hung des immunchemisch gemessenen Seruminsulins im peripheren Venenblut. Es wurden zwei kurzzeitige Peaks zwischen der 5. mad 10. sowie der 15. and 25. rain beobachtet. In geringerem Ausmal~ fanden sich diese beiden Peaks auch nach Scheinfiitterung mit Leitungswasser. Sic entsprechen in ihrer zeitlie...

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Section: Discussionsupporting

confidence: 76%

The Mechanism of Insulin Secretion after Oral Glucose Administration

et al. 1972

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“…Thus, we could exclude a stimulatory action of HC1 under these conditions. Exocrine pancreatic secretion is stimu lated by gastric distension in dogs [6,7] and cats [36], In man. distension volumes ex ceeding 200 ml evoke pancreatic enzyme se cretion accounting for nearly twofold in creases in amylase release [8.…”

Section: Discussionmentioning

confidence: 99%

“…5] which is abol ished by vagotomy [5], In addition, a func tional linkage between the stomach and the exocrine pancreas has been known for more than 20 years. White et al [6] demonstrated protein release from the innervated pancreas by gastric distension in dogs: this was not observed after atropinization, vagotomy or in the transplanted denervated pancreas. These findings were confirmed by others [7], In man, distension volumes exceeding 200 ml [8.…”

Section: Introductionmentioning

confidence: 99%

Cholecystokinin Release by Gastric Distension – An Atropine-Sensitive Mechanism

Koop

Ruppert-Seipp²,

Koop³

et al. 1990

Digestion

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The effect of gastric distension on plasma cholecystokinin (CCK), pancreatic polypeptide (PP) and gastrin concentrations was investigated in healthy volunteers. Fundic and antral distension was achieved by balloons attached to a gastric tube and inflated with 300 and 600 ml and 100 and 200 ml of air for fundic and antral distension, respectively. Gastric juice was continuously aspirated. Fundic distension was additionally studied during a concomitant intravenous infusion of atropine (5 µg/kg/h) or a bolus injection of propranolol (2 mg). Fundic distension with 300 ml caused a significant increase in PP release (+ 17% above basal). Distension with 600 ml significantly stimulated CCK (+ 81 %), gastrin (+ 31 %) and PP output (+ 74%) over 30 min. Atropine completely blocked PP release and almost abolished CCK release, whereas gastrin output was enhanced. Propranolol did not prevent CCK release induced by fundic distension, whereas gastrin and PP responses were diminished. Antral distension did not cause any significant changes in hormone response. In conclusion, we demonstrated a gastric phase of CCK release which is atropine sensitive, but not influenced by propranolol.

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“…Harper & Vass (1941) used casein and starch solutions in their experiments, and these may be ineffective as antral stimulants. More surprising in the light of our results is the claim of White, Lundh' & Magee (1960) that distension of pyloric pouches in dogs depressed pancreatic secretion. This cannot be explained as a species difference, since Passaro & Grossman (1963) found that canine pancreatic transplants were stimulated when separated pyloric pouches were irrigated with acetylcholine or liver extract.…”

Section: Discussionmentioning

confidence: 52%

A gastric phase of pancreatic secretion

Blair¹,

Brown²,

Harper³

et al. 1966

The Journal of Physiology

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SUMMARY1. Extracts of antral mucosa increase the output of pancreatic amylase. They do not stimulate the resting pancreas of the anaesthetized cat to secrete juice, but have a slight 'secretin-like' effect on a pancreas already responding to endogenous or exogenous secretin.2. In animals with the vagus and splanchnic nerves cut instillation of meat extracts or acetylcholine into the antrum stimulates gastric acid and pancreatic amylase secretion. These responses can be prevented by injection of atropine or cocainization of the antral mucosa.3. In animals with the splanchnic nerves cut but the vagus nerves intact, distension of the body or antrum increases the output of amylase. After vagal section distension of the body has no effect on the pancreas, but the response to antral distension is still present.4. It is concluded that there is a gastric phase of pancreatic secretion which, in the cat, is almost entirely a stimulation of enzyme output. A vago-vagal reflex pathway is required for the pancreatic response to mechanical stimulation of the body of the stomach, and may be involved in the response to antral stimulation. Chemical and mechanical stimulation of the antrum produces a hormonally mediated increase in pancreatic enzyme secretion. The effects of atropine and cocaine on this response are consistent with the view that the release of the antral stimulant depends on a local cholinergic reflex pathway in the antrum.

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Evidence for the existence of a gastropancreatic reflex

Cited by 79 publications

References 0 publications

The Mechanism of Insulin Secretion after Oral Glucose Administration

The Mechanism of Insulin Secretion after Oral Glucose Administration

Cholecystokinin Release by Gastric Distension – An Atropine-Sensitive Mechanism

A gastric phase of pancreatic secretion

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