Evidence for placebo effects on physical but not on biochemical outcome parameters: a review of clinical trials

Meißner, Karin; Distel, Hans; Mitzdorf, U.

doi:10.1186/1741-7015-5-3

Cited by 82 publications

(60 citation statements)

References 85 publications

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“…For example, one could conclude that those who participate more are more likely to perceive a positive effect on their well-being; this could be interpreted as a form of placebo effect. Yet it has been widely demonstrated that such effects work in improving overall well-being (Beauregard, 2007;Koshi & Short, 2007;Meissner, Distel, & Mitzdorf, 2007), and it does seem clear that this is the case with CE membership as well. Because many people who join time banks are older and experiencing health problems, it would not be surprising to see some decline in health over time, especially among older members who have been members for several years.…”

Section: Limitationsmentioning

confidence: 99%

Time Banking and Health: The Role of a Community Currency Organization in Enhancing Well-Being

Lasker

Collom

Bealer

et al. 2010

Health Promotion Practice

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Section: Limitationsmentioning

confidence: 99%

Time Banking and Health: The Role of a Community Currency Organization in Enhancing Well-Being

Lasker

Collom

Bealer

et al. 2010

Health Promotion Practice

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“…While placebo has clinical benefits, it has not been shown to have specific effects in terms of biologic markers. [20][21][22][23] There are some intriguing findings in this study even as a single case study. The lengthy RNG control sessions in nontherapeutic settings such as a business office had Z scores of 0.03, as expected, with no trials having a Z score > 2.…”

Section: Discussionmentioning

confidence: 69%

Benefits of Reiki Therapy for a Severely Neutropenic Patient with Associated Influences on a True Random Number Generator

Morse¹,

Beem²

2011

The Journal of Alternative and Complementary Medicine

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Background: Reiki therapy is documented for relief of pain and stress. Energetic healing has been documented to alter biologic markers of illness such as hematocrit. True random number generators are reported to be affected by energy healers and spiritually oriented conscious awareness. Methods: The patient was a then 54-year-old severely ill man who had hepatitis C types 1 and 2 and who did not improve with conventional therapy. He also suffered from obesity, the metabolic syndrome, asthma, and hypertension. He was treated with experimental high-dose interferon/riboviron therapy with resultant profound anemia and neutropenia. Energetic healing and Reiki therapy was administered initially to enhance the patient's sense of well-being and to relieve anxiety. Possible effects on the patient's absolute neutrophil count and hematocrit were incidentally noted. Reiki therapy was then initiated at times of profound neutropenia to assess its possible effect on the patient's absolute neutrophil count (ANC). Reiki and other energetic healing sessions were monitored with a true random number generator (RNG). Results: Statistically significant relationships were documented between Reiki therapy, a quieting of the electronically created white noise of the RNG during healing sessions, and improvement in the patient's ANC. The immediate clinical result was that the patient could tolerate the high-dose interferon regimen without missing doses because of absolute neutropenia. The patient was initially a late responder to interferon and had been given a 5% chance of clearing the virus. He remains clear of the virus 1 year after treatment. Conclusions: The association between changes in the RNG, Reiki therapy, and a patient's ANC is the first to the authors' knowledge in the medical literature. Future studies assessing the effects of energetic healing on specific biologic markers of disease are anticipated. Concurrent use of a true RNG may prove to correlate with the effectiveness of energetic therapy.

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“…Such a response is defined as 'the psychobiological response seen after administration of a non-therapeutic modality'. Placebo treatments have known effects on endogenous pharmacology, as well as the cognitive and conditioning systems in humans [312][313][314][315][316][317][318][319]. The placebo response rate is higher in children compared with adults [320,321].…”

Section: The Mechanism and Effects Of Ivlt In Chronic Painmentioning

confidence: 99%

A Review of Intravenous Lidocaine Infusion Therapy for Paediatric Acute and Chronic Pain Management

Lauder¹

2017

Pain Relief - From Analgesics to Alternative Therapies

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Pediatric acute and chronic pain experiences involve the interaction of physiological, psychological, behavioural, developmental, pharmacological and situational factors. In the acute perioperative pain setting preventative multimodal analgesia is required to provide comfort and minimise the potential for "wind-up" and central sensitisation. When pain is recurrent, ongoing or chronic some children embark on a downward spiral of decreased physical, psychological and social functioning. The multidisciplinary team management approach is a well-established standard of care for children with complex chronic pain. Intravenous lidocaine has peripheral and central mediated analgesic, anti-inflammatory and anti-hyperalgesic properties. Intravenous lidocaine infusion therapy (IVLT) has been shown to be effective in the management of acute and chronic pain in adults. This chapter will present the rational for IVLT in pediatric pain management with emphasis on preventative multimodal therapy in acute pain and the multidisciplinary treatment approach in chronic pain. Large multi-centre randomised controlled trials are required to provide the evidence-base to confirm that IVLT is indeed an effective and safe treatment option in acute preventative multimodal analgesia and as an adjunct in the multidisciplinary care of chronic pain in the pediatric population. Keywords

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Evidence for placebo effects on physical but not on biochemical outcome parameters: a review of clinical trials

Cited by 82 publications

References 85 publications

Time Banking and Health: The Role of a Community Currency Organization in Enhancing Well-Being

Time Banking and Health: The Role of a Community Currency Organization in Enhancing Well-Being

Benefits of Reiki Therapy for a Severely Neutropenic Patient with Associated Influences on a True Random Number Generator

A Review of Intravenous Lidocaine Infusion Therapy for Paediatric Acute and Chronic Pain Management

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