Evidence for multiple alleles effecting muscling and fatness at the Ovine GDF8 locus

Kijas, James W.; McCulloch, Russell; Edwards, J. E. Hocking; Oddy, V. H.; Lee, Sang; Werf, J. H. J. van der

doi:10.1186/1471-2156-8-80

Cited by 101 publications

(127 citation statements)

References 20 publications

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“…Possible candidate genes in these regions (genes known to influence weight-related traits in sheep or other species) identified by Raadsma et al (2009) include myostatin, beta-3-adrenergic receptor, melanocortin 4 receptor, erythropoietin, elastin and fibrosin genes. Myostatin (also known as growth differentiation factor 8, GDF8), located in the center of the region on chromosome 2, is perhaps the most promising of these genes because it has been linked to muscle development in domestic sheep (Clop et al, 2006;Kijas et al, 2007) and cattle ( Casas et al, 1999). Although anti-conservative, our test for the colocalization of body mass QTL nonetheless highlighted chromosomal areas deserving further investigation and suggested that the genetic architecture of body mass may be partially conserved across species.…”

Section: Body Massmentioning

confidence: 96%

QTL mapping for sexually dimorphic fitness-related traits in wild bighorn sheep

et al. 2011

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Dissecting the genetic architecture of fitness-related traits in wild populations is key to understanding evolution and the mechanisms maintaining adaptive genetic variation. We took advantage of a recently developed genetic linkage map and phenotypic information from wild pedigreed individuals from Ram Mountain, Alberta, Canada, to study the genetic architecture of ecologically important traits (horn volume, length, base circumference and body mass) in bighorn sheep. In addition to estimating sex-specific and cross-sex quantitative genetic parameters, we tested for the presence of quantitative trait loci (QTLs), colocalization of QTLs between bighorn sheep and domestic sheep, and sexÂQTL interactions. All traits showed significant additive genetic variance and genetic correlations tended to be positive. Linkage analysis based on 241 microsatellite loci typed in 310 pedigreed animals resulted in no significant and five suggestive QTLs (four for horn dimension on chromosomes 1, 18 and 23, and one for body mass on chromosome 26) using genome-wide significance thresholds (Logarithm of odds (LOD) 43.31 and 41.88, respectively). We also confirmed the presence of a horn dimension QTL in bighorn sheep at the only position known to contain a similar QTL in domestic sheep (on chromosome 10 near the horns locus; nominal Po0.01) and highlighted a number of regions potentially containing weight-related QTLs in both species. As expected for sexually dimorphic traits involved in male-male combat, loci with sex-specific effects were detected. This study lays the foundation for future work on adaptive genetic variation and the evolutionary dynamics of sexually dimorphic traits in bighorn sheep.

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Section: Body Massmentioning

confidence: 96%

QTL mapping for sexually dimorphic fitness-related traits in wild bighorn sheep

et al. 2011

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“…A mutation in the myostatin (GDF8) gene resulting in inhibited transcription has been shown to increase muscularity in Texel sheep and other breeds (Clop et al, 2006). Other studies have reported that myostatin mutations influence muscle and fat (Kijas et al, 2007;Lambe et al, 2011).…”

Section: Genesmentioning

confidence: 99%

“…However, a reduction of intramuscular fat and sensory scores on overall meat quality, including juiciness, was observed (Kijas et al, 2007;Hopkins et al, 2011). Masri et al (2011b) observed that myostatin mutations in Texel and Poll Dorset breeds reduce Longissimus intramuscular fat.…”

Section: Genesmentioning

confidence: 99%

Intrinsic factors affecting sheep meat quality: a review

Júnior

Carvalho

Silva

et al. 2016

Rev Colomb Cienc Pecu

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SummaryThe quality of meat is a multifactorial parameter dependent on the perspective and goals of the link in the production chain. Generally, a variety of factors directly or indirectly affect the quality characteristics of meat and, therefore, the value of meat products. Often, the literature divides the interfering factors into intrinsic and extrinsic. Intrinsic factors are related to animals; therefore, intrinsic factors are less variable. These factors include breed, sex, age, weight, genes, and type of muscle fiber. Some of these factors are not well studied, others have variable influence or are controversial and only a few are known and sometimes controlled. Thus, this study aimed to review some intrinsic factors that influence the quality of lamb meat. Keywords: cooking losses, meat color, tenderness, water holding capacity. ResumenLa calidad de la carne es un parámetro multifactorial que depende de la perspectiva y los objetivos del eslabón de la cadena de producción. En general, una amplia variedad de factores afectan directa o indirectamente la calidad de la carne y, en consecuencia, los valores de los productos cárnicos. A menudo, la literatura divide los factores que interfieren intrínseca y extrínsecamente. Los factores intrínsecos están relacionados con los animales, por lo tanto, son menos variable. Estos factores incluyen la raza, el género, la edad, el peso, los genes y ResumoA qualidade da carne é um parâmetro multifatorial, dependente da perspectiva e objetivos do elo da cadeia produtiva. Geralmente, uma grande variedade de fatores afetam direta ou indiretamente as características de qualidade da carne e, consequentemente, os valores dos produtos cárneos. Frequentemente, a literatura divide os fatores interferentes em intrínsecos e extrínsecos. Os fatores intrínsecos são referentes ao animal e, portanto, menos variáveis. Esses fatores incluem raça, sexo, idade, peso, genes e tipo de fibras musculares. Alguns desses fatores não estão bem estudados, outros têm influência variável ou controvertida e somente alguns são conhecidos e, às vezes, controlados. Dessa forma, objetivou-se revisar alguns fatores intrínsecos que influenciam na qualidade da carne ovina.Palavras chave: capacidade de retenção de água, cor da carne, maciez da carne, perdas por cocção.

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“…A single DNA marker that predicts genotype for horns/polled with 99.8 accuracy was identified from the SNP data (Dominik et al 2012). A myostatin gene known to affect muscling (Kijas et al 2007) and known to be segregating in the FMFS population was identified, albeit with precision of~15 cM. The lower precision of detecting location for a gene known to affect muscling (a multi-locus trait) was not a function of poor SNP density in the region but rather a consequence of the low number of recombinations observed around particular loci.…”

Section: Discussionmentioning

confidence: 99%

Design and phenotyping procedures for recording wool, skin, parasite resistance, growth, carcass yield and quality traits of the SheepGENOMICS mapping flock

et al. 2012

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Abstract.A major aim of the research program known as SheepGENOMICS was to deliver DNA markers for commercial breeding programs. To that end, a resource flock was established, comprehensively phenotyped and genotyped with DNA markers. The flock of nearly 5000 sheep, born over two consecutive years, was extensively phenotyped, with more than 100 recorded observations being made on most of the animals. This generated more than 460 000 records over 17 months of gathering information on each animal. Here, we describe the experimental design and sample-collection procedures, and provide a summary of the basic measurements taken. Data from this project are being used to identify collections of genome markers for estimating genomic breeding values for new sheep industry traits.

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Evidence for multiple alleles effecting muscling and fatness at the Ovine GDF8 locus

Abstract: Background: The current investigation surveyed genetic polymorphism at the ovine GDF8 locus and determined its contribution to variation in muscling and fatness in sheep.

Cited by 101 publications

References 20 publications

QTL mapping for sexually dimorphic fitness-related traits in wild bighorn sheep

QTL mapping for sexually dimorphic fitness-related traits in wild bighorn sheep

Intrinsic factors affecting sheep meat quality: a review

Design and phenotyping procedures for recording wool, skin, parasite resistance, growth, carcass yield and quality traits of the SheepGENOMICS mapping flock

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