Evidence for Infection of Sheep in Victoria With Leptospires of the Hebdomadis Serogroup

McCAUGHAN, C. J.; Gordon, L. M.; Rahaley, R. S.; Slee, K. J.; Presidente, P. J. A.

doi:10.1111/j.1751-0813.1980.tb05690.x

Cited by 15 publications

(6 citation statements)

References 10 publications

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“…Baker et al (1989) found a signifi cant association (OR 4.6; p=0.03) between titres *1:80 to serovar Pomona and carcasses with multifocal interstitial nephritis in a prevalence survey but not in a small sample size case-control study with low power. In many earlier studies, white-spot lesions were consistently observed in sheep (Dozsa and Sahu 1970;Smith and Armstrong 1975;Davidson and Hirsh 1980;McCaughan et al 1980;Ellis et al 1984;Kingscote 1985) and deer (Wilson et al 1998) with leptospirosis, in contrast to observations for cattle. Other studies in pigs (Jones et al 1987;Boqvist et al 2003) and cattle (Prescott et al 1987;Skilbeck et al 1988;Uzal et al 2002) found no signifi cant associations but were based on small samples.…”

Section: Discussionmentioning

confidence: 78%

“…Although WSK are not pathognomonic for leptospirosis (Jeffcott et al 1967;Drolet and Dee 1999), they are frequently observed in natural and experimental infections with Leptospira spp. in cattle (Hadlow and Stoenner 1955;Amatredjo et al 1976), pigs (Cheville et al 1980;Jones et al 1987) and sheep (Marshall 1974;Durfee and Presidente 1979;Hathaway and Marshall 1979;McCaughan et al 1980;Ellis et al 1984;Vermunt et al 1994ab). This association has led meat inspectors and slaughterhouse workers to assume that WSK could be indicators of past or current leptospiral infection, and kidneys were condemned as a consequence (Uzal et al 2002).…”

Section: Introductionmentioning

confidence: 95%

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Are white-spot lesions in kidneys in sheep associated with leptospirosis?

Dorjee

Heuer

Jackson

et al. 2009

New Zealand Veterinary Journal

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 95%

Are white-spot lesions in kidneys in sheep associated with leptospirosis?

Dorjee

Heuer

Jackson

et al. 2009

New Zealand Veterinary Journal

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“…Também pode haver hemoglobinemia e hemoglobinúria (Faine et al, 1999). Na forma crô-nica, abortamentos e natimortalidade são considerados como as manifestações mais frequentes (Broom, 1953;Davidson, 1971;Mccaughan et al, 1980;Ellis, et al, 1983;Motie, 1986;Leon-Vizcaino, 1987;Ellis, 1994;Faine et al, 2000;Cicceroni et al, 2000;Martins, 2012). Em caprinos, também pode haver diminuição da produção de leite e agalactia (McKeown; Ellis, 1986 …”

Section: Aspectos Clínicos Da Leptospirose Em Pequenos Ruminantesunclassified

Leptospirose em pequenos ruminantes: situação epidemiológica atual no Brasil

Higino

Azevêdo

2014

Arq. Inst. Biol.

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Leptospirosis in small ruminants is a disease that can lead to economic losses due to the occurrence of abortions, stillbirths and decreased milk production. The infection can be presented in acute, chronic and inapparent forms. In the acute infection, anorexia, depression, difficulty breathing, fever, hemoglobinemia and hemoglobinuria can occur. In the chronic form, abortions and stillbirths are common. Several recent serological surveys conducted in Brazil revealed frequencies of seropositivity ranging from 3.4 to 31.3% in goats, and from 0.7 to 34.6% in sheep. Most frequent reactions were obtained with the serovars Autumnalis, Grippotyphosa, Hardjo, Icterohaemorrhagiae and Pyrogenes. The microscopic agglutination test is the most used method to diagnose the infection. The control of leptospirosis in small ruminants is based on the identification of sources of infection, rodent control, control in animal purchasing and systematic immunization with inactivated vaccines that contain regional serovars of leptospires.KEYWORDS: Leptospira spp.; small ruminants; epidemiology; control; prevention. RESumO:A leptospirose em pequenos ruminantes é uma doença que pode causar perdas econômicas devido à ocorrência de abortamentos, natimortalidade e diminuição da produção de leite. A infecção pode se apresentar nas formas aguda, crônica e inaparente. Na forma aguda, pode ocorrer anorexia, depressão, dificuldade respiratória, febre, hemoglobinemia e hemoglobinúria. Na forma crônica, abortamentos e natimortalidade são comuns. Vários inqué-ritos sorológicos recentes conduzidos no Brasil apontaram frequências de soropositividade variando de 3,4 a 31,3% em caprinos, e de 0,7 a 34,6% em ovinos. Os sorovares reatores mais frequentes foram Autumnalis, Grippotyphosa, Hardjo, Icterohaemorrhagiae e Pyrogenes. O teste de soroaglutinação microscópica é o método mais empregado para o diagnóstico da infecção. O controle da leptospirose em pequenos ruminantes é baseado na identificação de fontes de infecção, controle de roedores, controle da aquisição de animais e imunização sistemática com vacinas inativadas que contenham sorovares de leptospiras regionais.Palavras-chave: Leptospira spp.; pequenos ruminantes; epidemiologia; controle; prevenção.

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“…Among the most common observations attributed to suspected cases of acute Leptospira spp. infection, necrotizing lesions in the liver (Davidson & Hirsh, ; Dutra, ; Hartley, ; Singh et al., ; Vermunt, West, Cooke, Alley, & Collins‐Emerson, 1994a) and/or inflammatory lesions in the kidneys have been reported (Hartley, ; Rafyi & Maghami, ; Amjadi & Ahourai, ; McCaughan, Gordon, Rahaley, Slee, & Presidente, ; Throssell, ; Davidson & Hirsh, ; Schmitz, Coles, & Shires, ; Singh et al., ; Mitchell & Leonard, ; Vermunt et al., 1994a; Vermunt, West, Arthur, & Marshall, 1994b; Dutra, ). Clinical signs and lesions suggestive of leptospirosis have been associated with the histologic observation of the bacteria in the kidneys (Hartley, ; Mitchell & Leonard, ; Singh et al., ), observation of the spirochetes by dark‐field microscopy (Schmitz et al., ) and PCR amplification in urine (Dutra, ) or with serum antibodies (Amjadi & Ahourai, ; Davidson & Hirsh, ; McCaughan et al., ; Mitchell & Leonard, ; Singh et al., ; Throssell, ; Vermunt et al., ,b).…”

Section: Introductionmentioning

confidence: 99%

Leptospira interrogansserogroup Pomona serovar Kennewicki infection in two sheep flocks with acute leptospirosis in Uruguay

Hamond

Silveira

Buroni

et al. 2019

Transbound Emerg Dis

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Summary Acute leptospirosis is an infrequent disease in sheep that can cause jaundice, haemolysis, haemoglobinuria, hepatitis and nephritis. In most reports the diagnoses have been made by clinical, pathological or serological evidence without isolation or direct identification of the agent. Here, we report one confirmed and one presumptive outbreak of acute leptospirosis in suckling lambs from two unrelated sheep farms in Uruguay with mortalities of 9/60 (15%) and 9/163 (5.5%) lambs. Both outbreaks occurred in Sep–Oct 2017 after heavy rainfall and flooding events. The main gross and histologic pathological findings in two autopsied lambs, one from each farm, included severe diffuse jaundice, haemoglobinuria, acute necrotizing hepatitis with cholestasis and interstitial nephritis. Leptospira interrogans serogroup Pomona serovar Kennewicki was isolated from sheep in both flocks and the same genotype was identified directly in clinical samples from infected animals, including one of the deceased lambs subjected to autopsy, by amplification and partial sequencing of rrs and secY genes. This serovar has recently been identified in infected cattle and humans in Uruguay. The impact of Leptospira spp. infection in ovine health, and the epidemiologic role of sheep as reservoirs of leptospirosis for humans and animals need further investigation.

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Evidence for Infection of Sheep in Victoria With Leptospires of the Hebdomadis Serogroup

Cited by 15 publications

References 10 publications

Are white-spot lesions in kidneys in sheep associated with leptospirosis?

Are white-spot lesions in kidneys in sheep associated with leptospirosis?

Leptospirose em pequenos ruminantes: situação epidemiológica atual no Brasil

Leptospira interrogansserogroup Pomona serovar Kennewicki infection in two sheep flocks with acute leptospirosis in Uruguay

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