Events of wound healing/regeneration in the canine supraalveolar periodontal defect model

Abstract

Activation of cellular regenerative events in periodontal wound healing/regeneration is rapid; the general framework for tissue formation is broadly outlined within 14 days. Most bone formation apparently originates from endosteally derived pre-osteoblasts; the PDL possibly acting as a supplementary source, with a primary function likely being regulatory/homeostatic. Blood accumulation at the surgical site warrants exploration; supplementation may be beneficial.

Combined effects of systemic parathyroid hormone (1–34) and locally delivered neutral self‐assembling peptide hydrogel in the treatment of periodontal defects: An experimental in vivo investigation

“…The in vivo efficacy of SPG‐178 as a local haemostatic material has also been reported (Komatsu et al, ). In the early stage of periodontal healing, some blood clot fills the wound space and a layer of vascularized periosteal tissues covers the new bone and contacts the PDL (Dickinson et al, ). The clot filling the remainder of the wound space is eventually replaced by the newly forming bone.…”

Periodontal regeneration via chemoattractive constructs

“…Currently, the successful application of guided tissue regeneration (GTR) with most predictable clinical results is limited to certain defect morphology (e.g., two and three‐wall intrabony defects, class II mandibular furcations), patient’s characteristics (good oral hygiene, nonsmokers) and surgeons’ experience (skills, decision‐making) (Villar & Cochran, ). The concept of endogenous cell recruitment can be considered as very suitable and appealing for this purpose, particularly, in view of modifying the early phase of wound healing, which has been proposed to be the main target of future periodontal regenerative technique (Dickinson et al., ; Susin & Wikesjo, ). Increasing evidence in the field of regenerative medicine suggests that cell recruitment stimulates latent self‐repair mechanisms in patients and harnesses the innate capacity for tissue regeneration (Chen, Wu, Zhang, Zhang, & Sun, ).…”

“…As the mechanism underlying this enhanced periodontal regeneration, Zhou et al have found that bone marrow-derived stem cells migrated preferentially to the periodontium over other organs to get involved in periodontal regeneration (Zhou et al, 2011). In addition to this cell recruitment efficacy, SDF-1α is anticipated to modify the inflammatory response and early wound healing (Chen et al, 2015;Dickinson et al, 2013;Zhao et al, 2017).…”

Effect of 1% sodium alendronate in the non-surgical treatment of periodontal intraosseous defects: a 6-month clinical trial

“…It is highly prevalent among adult populations 1 . Because of the previously demonstrated capacity of the periodontal tissues for regeneration 8 , there has been increased interest in the mechanisms of periodontal wound healing and the biological factors and cells involved in this process 13 . A wide range of regenerative techniques has been proposed along the years, many of those involving bone grafts or their synthetic substitutes 13 , guided tissue regeneration 21 , topical application of growth factors 22 , stem cells 11 , antiresorptive agents 27 , or combinations of procedures 13,22 .…”