Event-Related Brain Potentials: Comparison Between Children and Adults

Courchesne, Eric

doi:10.1126/science.877575

Cited by 153 publications

(94 citation statements)

References 12 publications

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“…The developmental changes in P300 amplitude and topography in have been explored by very few cross-sectional normative studies in the visual modality (Courchesne, 1977;Courchesne, 1978). The amplitudes of visual P300 have been reported to decrease with age in children and adolescents.…”

Section: P300 Amplitude Changesmentioning

confidence: 99%

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Rangaswamy

Jones

Porjesz

et al. 2007

International Journal of Psychophysiology

117

136

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Background-Visual P300 is consistently lower in alcohol dependent individuals, their offspring and subjects at risk. Delta and theta event related oscillations (ERO) are the major contributors to the P300 signal. The total and evoked power in delta and theta bands in the 300 to 700 millisecond post-stimulus window (corresponding to the zone of P3 maxima) was compared between adolescent offspring of alcoholics (high-risk) and age-matched normal controls (low-risk), to assess the utility of the risk markers.Methods-EEG was recorded during the performance of visual oddball task. The S-Transform algorithm decomposed the EEG signals into different frequency bands and the group differences in total and evoked power in the oscillatory responses during the P300 time window (300 to 700 ms) were analyzed using a multivariate design. Similar analysis was performed on P300 peak amplitudes for the target.Results-The high-risk group showed significantly lower parietal post-stimulus evoked and total power in the delta band for targets. A decrease in total power was seen centrally and parietally in theta band. The P300 peak amplitude in the parietal electrodes was also significantly lower in the high-risk group.Conclusions-The decreased total theta power and total and evoked delta power for visual targets in high risk individuals may serve as an endophenotypic marker in the development of alcoholism and other disinhibitory disorders. The differences seen between the offspring of alcoholics and controls may have a cholinergic basis. The ERO measures appear to be more robust than the P300 amplitude in differentiating the groups.

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Section: P300 Amplitude Changesmentioning

confidence: 99%

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Rangaswamy

Jones

Porjesz

et al. 2007

International Journal of Psychophysiology

117

136

View full text Add to dashboard Cite

show abstract

“…Previous studies employing simple oddball or novelty tasks in this age range have yielded mixed results. Mostly P3 amplitude is seen to decrease in childhood (Courchesne, 1977(Courchesne, , 1978(Courchesne, , 1983(Courchesne, ,1990Friedman, 1991;Stauder, 1992), although some studies have reported no change (Wijker, 1991) or even increases (Mullis, Holcomb, Diner, & Dykman, 1985;Polich et al, 1990;Taylor, 1988). However, an apparent increase in P3 amplitude with age may be caused by the age-related decrease in variability in the latency of single trials.…”

Section: Longitudinal Analysesmentioning

confidence: 99%

“…EEG rhythms are driven mainly from subcortical areas and may bear little relation to the functional development of the cortical cell layers. In contrast, development of stimulus-evoked changes in EEG, the so-called ERPs, appears to closely mirror the time course of development of gray and white matter (Courchesne, 1977;Courchesne, Elmasian, & Young-Courchesne, 1987). The P3 (also known as P300) shows particular promise.…”

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confidence: 99%

Longitudinal study of genetic influences on ERP‐P3 during childhood

Baal

Geus

Boomsma

1998

Developmental Neuropsychology

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The P3, a component of the event-related potential, is an electrophysiological reaction of the brain to an event. It has been extensively studied as an index of attentional and memory processes in humans, and the substantial individual variation in its amplitude and latency has been related to individual differences in cognitive function and ability. Little is known about the relative contributions of genetic and environmental influences to the individual differences in this event-related potential component. Furthermore, it is unclear whether and how these influences vary during maturation in childhood. In this study, P3 was measured twice in 164 young twin pairs, once at age 5, and once at age 7. Participants performed a visual oddball task with 100 nontarget and 25 target stimuli. P3 amplitudes and latencies were obtained at 6 scalp locations (C3, Cz, C4, P3, Pz, and P4). Results show an effect of age (smaller amplitudes and shorter latencies at age 7 than at age 5), stimulus type (larger amplitudes and longer latencies for targets than for nontargets), and electrode location (largest P3 amplitude at Pz, longest P3 latencies at central electrodes). No gender differences were found for mean amplitude or latency. A genetic model was fitted to the data that decomposed the reliable variances and covariances of P3 at ages 5 and 7 into genetic and environmental parts. A significant part of the true variance in P3 latency was genetic. Heritabilities were 13% to 78% at age 5 and 36% to 99% at age 7. Heritabilities for P3 amplitude in response to targets were low (0%-19%) but high in response to nontargets (36%-86%) at both ages. At most scalp locations, the same set of genes influenced latency and amplitude from age 5 to age 7. An additional genetic factor common to the latency of targets and nontargets was found at age 7, but only for Cz and P3 scalp locations. We conclude that Requests for reprints should be sent to G.

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“…Early investigations showed that rare nontarget stimuli elicit different ERP components in children and adults, while equally rare, target stimuli elicit similar components in children and adults (Courchesne, 1977). It was found that a broad frontal negativity, known as the NC component, decreases with age (Courchesne, 1978), but P300 increases in amplitude and decreases in latency with age .…”

Section: Normal Developmentmentioning

confidence: 99%