Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

Duncan, Connie C.; Barry, Robert J.; Connolly, John F.; Fischer, Catherine; Michie, Patricia T.; Näätänen, Risto; Polich, John; Reinvang, Ivar; Petten, Cyma Van

doi:10.1016/j.clinph.2009.07.045

Cited by 995 publications

(937 citation statements)

References 339 publications

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“…Within a network model of semantic memory, these N400 semantic priming effects (N400 amplitude difference between unrelated and related targets) reflect greater activation of concepts that are more related to preceding context. Thus, N400 semantic priming effects have been used as a neurophysiological probe of abnormal semantic activation in clinical populations (reviewed by Duncan et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Test–retest reliability of N400 event-related brain potential measures in a word-pair semantic priming paradigm in patients with schizophrenia

Boyd¹,

Patriciu²,

McKinnon³

et al. 2014

Schizophrenia Research

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Abstract:The N400 event-related brain potential (ERP), a negative voltage deflection occurring approximately 400 ms after onset of any meaningful stimulus, is reduced in amplitude when the stimulus is preceded by related context. Previous work has found this N400 semantic priming effect to be decreased in schizophrenia, suggesting impairment in using meaningful context to activate related concepts in semantic memory. Thus, N400 amplitude may be a useful biomarker of abnormal semantic processing and its response to treatment in schizophrenia. To help assess validity of N400 amplitude as a longitudinal measure in schizophrenia, we evaluated its testretest reliability. ERPs were recorded in sixteen schizophrenia patients who viewed prime words, each followed at 300-or 750-ms stimulus-onset asynchrony (SOA) by a target that was either a related or unrelated word, or nonword. Participants' task was to indicate whether or not the target was a real word. They were retested on the same procedure one week later. Test-retest reliability was assessed by calculating Pearson's r and intraclass correlation coefficients (ICCs) across timepoints for N400 amplitudes for related and unrelated targets, at each SOA. Consistent with previous results, there were no significant differences between patients' N400 amplitudes for related and unrelated targets, at any SOA/timepoint combination. Pearson's r and ICCs for N400 amplitudes at Fz across timepoints were significant for both target types at each SOA (ranges: r 0.52-0.64, ICC 0.52-0.63; all p < .04). The results suggest potential utility of N400 amplitude as a longitudinal neurophysiological biomarker of semantic processing abnormalities in schizophrenia.3 Test-retest reliability of N400 event-related brain potential measures in a word-pair semantic priming paradigm in patients with schizophrenia

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Section: Introductionmentioning

confidence: 99%

Test–retest reliability of N400 event-related brain potential measures in a word-pair semantic priming paradigm in patients with schizophrenia

Boyd¹,

Patriciu²,

McKinnon³

et al. 2014

Schizophrenia Research

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“…Patients performed a standard auditory oddball task [14]. This task requires participants to press a predefined button with the index finder of the dominant hand in response to "target" tones (low frequency), but not to respond to "nontarget" tones (high frequency).…”

Section: Auditory Oddball Paradigmmentioning

confidence: 99%

“…In this cognitive paradigm, low-probability target stimuli ("oddballs", e.g., low frequency tones) are embedded in a train of highprobability nontarget stimuli ("standards", e.g., highfrequency tones). After the presentation of the infrequent target stimuli a large P3 can be measured at parietal midline electrodes [13,14].…”

Section: Introductionmentioning

confidence: 99%

The P3 Event-Related Potential is a Biomarker for the Efficacy of Vagus Nerve Stimulation in Patients with Epilepsy

et al. 2014

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Currently, the mechanism of action of vagus nerve stimulation (VNS) is not fully understood, and it is unclear which factors determine a patient's response to treatment. Recent preclinical experiments indicate that activation of the locus coeruleus noradrenergic system is critical for the antiepileptic effect of VNS. This study aims to evaluate the effect of VNS on noradrenergic signaling in the human brain through a noninvasive marker of locus coeruleus noradrenergic activity: the P3 component of the event-related potential. We investigated whether VNS differentially modulates the P3 component in VNS responders versus VNS nonresponders. For this purpose, we recruited 20 patients with refractory epilepsy who had been treated with VNS for at least 18 months. Patients were divided into 2 groups with regard to their reduction in mean monthly seizure frequency: 10 responders (>50 %) and 10 nonresponders (≤50 %). Two stimulation conditions were compared: VNS OFF and VNS ON. In each condition, the P3 component was measured during an auditory oddball paradigm. VNS induced a significant increase of the P3 amplitude at the parietal midline electrode, in VNS responders only. In addition, logistic regression analysis showed that the increase of P3 amplitude can be used as a noninvasive indicator for VNS responders. These results support the hypothesis that activation of the locus coeruleus noradrenergic system is associated with the antiepileptic effect of VNS. Modulation of the P3 amplitude should be further investigated as a noninvasive biomarker for the therapeutic efficacy of VNS in patients with refractory epilepsy.

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“…An improved passive oddball paradigm, proposed by Duncan et al (2009), was used for this experiment. Classic oddball paradigms usually contained one kind of deviant stimuli and one kind of standard stimuli in a block, whereas the improved paradigm contained more than one kind of deviant stimuli in a block.…”

Section: Methodsmentioning

confidence: 99%

Processing of Acoustic and Phonological Information of Lexical Tones in Mandarin Chinese Revealed by Mismatch Negativity

Wang¹,

Li²,

Yu³

et al. 2014

PsycEXTRA Dataset

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The accurate perception of lexical tones in tonal languages involves the processing of both acoustic information and phonological information carried by the tonal signal. In this study we evaluated the relative role of the two types of information in native Chinese speaker's processing of tones at a preattentive stage with event-related potentials (ERPs), particularly the mismatch negativity (MNN). Specifically, we distinguished the acoustic from the phonological information by manipulating phonological category and acoustic interval of the stimulus materials. We found a significant main effect of phonological category for the peak latency of MMN, but a main effect of both phonological category and acoustic interval for the mean amplitude of MMN. The results indicated that the two types of information, acoustic and phonological, play different roles in the processing of Chinese lexical tones: acoustic information only impacts the extent of tonal processing, while phonological information affects both the extent and the time course of tonal processing. Implications of these findings are discussed in light of neurocognitive processes of phonological processing.

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Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

Cited by 995 publications

References 339 publications

Test–retest reliability of N400 event-related brain potential measures in a word-pair semantic priming paradigm in patients with schizophrenia

Test–retest reliability of N400 event-related brain potential measures in a word-pair semantic priming paradigm in patients with schizophrenia

The P3 Event-Related Potential is a Biomarker for the Efficacy of Vagus Nerve Stimulation in Patients with Epilepsy

Processing of Acoustic and Phonological Information of Lexical Tones in Mandarin Chinese Revealed by Mismatch Negativity

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